The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(44), P. 10870 - 10879
Published: Oct. 26, 2024
Protein
aggregation
resulting
in
either
ordered
amyloids
or
amorphous
aggregates
is
not
only
restricted
to
deadly
human
diseases
but
also
associated
with
biotechnological
challenges
encountered
the
therapeutic
and
food
industries.
Elucidating
key
structural
determinants
of
protein
important
devise
targeted
inhibitory
strategies,
it
still
remains
a
formidable
task
owing
underlying
hierarchy,
stochasticity,
complexity
self-assembly
processes.
Additionally,
alterations
solution
pH,
salt
types,
ionic
strength
modulate
various
noncovalent
interactions,
thus
affecting
propensity
kinetics.
However,
molecular
origin
detailed
understanding
effects
weakly
strongly
hydrated
salts
on
their
plausible
roles
dissolution
remain
elusive.
In
this
study,
using
fluorescence
circular
dichroism
spectroscopy
combination
electron
microscopy
light
scattering
techniques,
we
show
that
size,
valency,
extent
hydration
cations
play
crucial
role
regulating
disaggregation
processes,
which
may
elicit
unique
methods
for
governing
balance
between
disassembly.
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 5, 2024
Misfolding
and
amyloid
fibrillogenesis
of
proteins
have
close
relationships
with
several
neurodegenerative
diseases.
The
present
work
investigates
the
inhibitive
activities
ankaflavin
(AK)
monascin
(MS),
two
yellow
pigments
separated
from
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(44), P. 10870 - 10879
Published: Oct. 26, 2024
Protein
aggregation
resulting
in
either
ordered
amyloids
or
amorphous
aggregates
is
not
only
restricted
to
deadly
human
diseases
but
also
associated
with
biotechnological
challenges
encountered
the
therapeutic
and
food
industries.
Elucidating
key
structural
determinants
of
protein
important
devise
targeted
inhibitory
strategies,
it
still
remains
a
formidable
task
owing
underlying
hierarchy,
stochasticity,
complexity
self-assembly
processes.
Additionally,
alterations
solution
pH,
salt
types,
ionic
strength
modulate
various
noncovalent
interactions,
thus
affecting
propensity
kinetics.
However,
molecular
origin
detailed
understanding
effects
weakly
strongly
hydrated
salts
on
their
plausible
roles
dissolution
remain
elusive.
In
this
study,
using
fluorescence
circular
dichroism
spectroscopy
combination
electron
microscopy
light
scattering
techniques,
we
show
that
size,
valency,
extent
hydration
cations
play
crucial
role
regulating
disaggregation
processes,
which
may
elicit
unique
methods
for
governing
balance
between
disassembly.
