Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

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Synergistic Effects of NO/H2S Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Fucoidan and its derivatives: From extraction to cutting-edge biomedical applications

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123468 - 123468

Published: March 1, 2025

Language: Английский

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Role of Probiotics against Human Cancers, Inflammatory Diseases, and Other Complex Malignancies

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 23

Published: Feb. 7, 2024

Probiotics have growing medical importance as a result of their potential in the prevention and therapeutic support several complex diseases, including different types cancers. The anticarcinogenic properties probiotics are attributed to various mechanisms, alterations composition intestinal microbiota, suppression cell proliferation, stimulation apoptosis, inhibition NF-kB, reduction levels H2AX, 8-hydroxy-deoxyguanosine, RIG-I, downregulation IL-17, TNF signaling pathway. Furthermore, demonstrated significant advantages management other diabetes, obesity, cardiovascular diseases. had considerable effect reducing inflammatory infiltration occurrence precancerous lesions. Additionally, administration led decrease appearance level genes related proinflammatory pathways, NF-κB, pathways. However, further research studies required comprehend processes via which exert effects authenticate alternative interventions.

Language: Английский

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Revisited and innovative perspectives of oral ulcer: from biological specificity to local treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 22, 2024

Mouth ulcers, a highly prevalent ailment affecting the oral mucosa, leading to pain and discomfort, significantly impacting patient’s daily life. The development of innovative approaches for ulcer treatment is great importance. Moreover, deeper more comprehensive understanding mouth ulcers will facilitate therapeutic strategies. environment possesses distinct traits as it serves gateway digestive respiratory systems. permeability various epithelial layers can influence drug absorption. mucosal injuries exhibit healing patterns compared cutaneous lesions, influenced by inherent extrinsic factors. Furthermore, moist dynamic environment, saliva physiological functions like chewing speaking, presents additional challenges in local therapy. Also, suitable adhesion materials are crucial alleviate promote process. To this end, review comprehensively examines anatomical structural aspects cavity, elucidates mechanisms explores factors contributing scar-free investigates application adhesive delivery This endeavor seeks offer novel insights perspectives ulcers.

Language: Английский

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Dodecyl glycoside intercalated organo-montmorillonite as the excipient for the development of alginate/organo-montmorillonite composite hydrogel beads based oral formulations for hydrophobic drug delivery

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: 709, P. 136154 - 136154

Published: Jan. 8, 2025

Language: Английский

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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 30, 2025

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101711 - 101711

Published: March 27, 2025

Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that mucosal adhesion properties of hydrogels play a potential role in treatment periodontitis. The hydrogel improve contact retention time drugs periodontal pocket. Through mucosa, it interacts mucin coating surface epithelium teeth to form specific interface force. exhibits strong (adhesion strength: 5-6 N/cm2) prolonged pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH reactive oxygen species (ROS). This design overcomes limitations poor mechanical stability conventional formulations. balance oral microbiota plays an important maintaining health. Probiotics, colonizing cavity, transform infected site from environment rich inflammatory cytokines more benign environment, inhibit harmful pathogenic microorganisms, contribute overall Microenvironment sensitive perform sol gel transformation situ, accurately control when exposed various stimuli (such as temperature change, light, species, etc.). Oral probiotics anti-inflammatory are encapsulated proliferation pathogens planting mouth producing metabolites, effectively preventing treating diseases.

Language: Английский

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Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5359 - 5359

Published: May 14, 2024

Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral parenteral dosage forms because it increases bioavailability reduces systemic toxicity. The mucosa has a good blood supply, which ensures that molecules enter the circulation directly, avoiding metabolism during first passage through liver. At same time, number of barriers, including mucus, epithelium, enzymes, immunocompetent cells, are designed prevent entry foreign substances into body, also complicates absorption drugs. development oromucosal delivery systems based on mucoadhesive biopolymers their derivatives (especially thiolated catecholated derivatives) promising strategy for pharmaceutical safe forms. Solid, semi-solid liquid formulations have several advantageous properties, such as prolonged residence time due high mucoadhesion, unidirectional modified release capabilities, enhanced permeability. Biopolymers non-toxic, biocompatible, biodegradable may possess intrinsic bioactivity. A rational approach design requires understanding anatomy/physiology physicochemical biopharmaceutical properties molecule/biopolymer, presented in this review. This review summarizes advances (e.g., patches, buccal tablets, hydrogel systems), nanotechnology-based biopolymer nanoparticle solid lipid particles, liposomes, polyelectrolyte hybrid nanoparticles, etc.).

Language: Английский

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