Nature’s Blueprints: Biomimicry and the Evolution of Sustainable Materials

Published: Jan. 1, 2025

Language: Английский

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Treatment of Mild-to-moderate Progressive Hemifacial Atrophy by Acellular Dermal Matrix Combined With Preoperative Digital Evaluation

Plastic & Reconstructive Surgery Global Open, Journal Year: 2025, Volume and Issue: 13(2), P. e6558 - e6558

Published: Feb. 1, 2025

Background: Progressive hemifacial atrophy (PHA) is a rare condition marked by the gradual degeneration of skin, soft tissues, muscles, and, in advanced stages, bone. The primary approach for managing PHA involves surgical interventions to reconstruct and restore facial contour. current treatments each present several limitations. Therefore, there critical need innovative therapeutic methodologies soft-tissue reconstruction. Methods: Eight patients diagnosed with Guerrerosantos II III were included study. Preoperative 3-dimensional scans digitally analyzed, corresponding 3-dimensional-printed models generated assess deficiencies. Based on this evaluation, acellular dermal matrix (ADM) was tailored stepped, multilayered composite dermis specific shape size. It then anatomically anchored at precise locations supplemented volume filler ligament-mimicking repairs. Results: location, volume, thickness ADM postoperatively highly compatible preoperative evaluations, significantly improving contour morphological volumetric differences. All achieved good healing without other complications reported improved postoperative scores FACE-Q craniofacial modules ( P < 0.05). Conclusions: Structural repair using ADM, guided digital assessments, provides safe, effective, relatively stable outcome. This achieving

Language: Английский

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Engineering High-Performance Multifunctional Scaffolds from the Acellular Dermal Matrix for Abdominal Wall Defects Repair via a Dopamine Progressive Permeation-Cross-Linking Strategy

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Emergency repair of complicated full-thickness abdominal wall defects remains one the most common and challenging surgical emergencies globally. Here, an integrated polydopamine permeating-cross-linking strategy was innovatively proposed to convert porcine acellular dermal matrix (pADM) into versatile, degradation-resistant biopatches (PDA-pADM) for efficiently repairing defects. The significantly addresses challenge that natural-property improvement biocompatibility biomaterials are difficult balance. Molecularly, dopamine (DA) molecules could fully permeate collagen fibers then automatically trigger interfacial in situ polymerization monomers among achieve efficient cross-linking pADM. Surprisingly, enzymatic durability biopatch shows significant improvements, extending original duration from 3 20 d. Comprehensive vivo experiments have shown PDA-pADM can effectively promote angiogenesis inhibit inflammatory response, so as regeneration damage.

Language: Английский

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Region-specific brain decellularized extracellular matrix promotes cell recovery in an in vitro model of stroke

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 7, 2025

Brain decellularized extracellular matrix (ECM) can be an attractive scaffold capable of mimicking the native ecosystem central nervous system tissue. We studied in vitro response neural cultures exposed to region-specific brain ECM scaffolds from three distinct neuroanatomical sections: cortex, cerebellum and remaining areas. First, each region was evaluated with isotropic fractionator method understand cellular composition different cerebral Second, regions were subjected decellularization process their respective characterization using molecular, histological, ultrastructural techniques. Third, levels neurotrophic factors analyzed. Fourth, we as a mimetic platform for maturation PC12 cells, unidirectional model differentiation. Finally, studies carried out evaluate cell recovery capacity under stroke-mimetic conditions. Our results show that serve biomimetic promoting growth lineage cells and, addition, it possesses combination structural biochemical signals (e.g., factors) are inducing phenotypic changes promote viability stroke/ischemia vitro.

Language: Английский

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Engineering cell-derived extracellular matrix for peripheral nerve regeneration

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101125 - 101125

Published: June 13, 2024

Extracellular matrices (ECMs) play a key role in nerve repair and are recognized as the natural source of biomaterials. In parallel to extensively studied tissue-derived ECMs (ts-ECMs), cell-derived (cd-ECMs) also have capability partially recapitulate complicated regenerative microenvironment native tissues. Notably, cd-ECMs can avoid shortcomings ts-ECMs. Cd-ECMs be prepared by culturing various cells or even autologous vitro under pathogen-free conditions. And mild decellularization achieve efficient removal immunogenic components cd-ECMs. Moreover, more readily customizable desired functional properties. These advantages garnered significant attention for potential neuroregenerative medicine. As promising biomaterials, bring new hope effective treatment peripheral injuries. Herein, this review comprehensively examines current knowledge about characteristics their mechanisms interaction with regeneration, particular focus on preparation, engineering optimization, scalability The applications from distinct cell sources reported tissue highlighted summarized. Furthermore, limitations that should addressed outlooks related clinical translation put forward well.

Language: Английский

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