Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 10, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
caused
by
insulin
resistance
(IR)
and
insufficient
secretion.
Its
characteristic
pathophysiological
processes
involve
the
interaction
of
multiple
mechanisms.
In
recent
years,
globally,
prevalence
T2DM
has
shown
sharp
rise
due
to
profound
changes
in
socio-economic
structure,
persistent
influence
environmental
factors,
complex
role
genetic
background.
It
worth
noting
that
most
patients
show
significant
IR,
which
further
exacerbates
difficulty
progression
prevention.
process
extensively
exploring
pathogenesis
T2DM,
dynamic
equilibrium
gut
microbes
its
diverse
activities
have
increasingly
emphasized
central
T2DM.
Bile
acids
(BAs)
metabolism,
as
crucial
link
between
development
not
only
precisely
regulates
lipid
absorption
metabolism
but
also
profoundly
influences
glucose
homeostasis
energy
balance
through
intricate
signaling
pathways,
thus
playing
pivotal
IR
This
review
aims
delve
into
specific
mechanism
BAs
contribute
especially
emphasizing
how
mediate
transformation
based
on
current
traditional
Chinese
medicine
research.
Ultimately,
it
seeks
offer
new
insights
prevention
treatment
Diet,
genetics,
environment
intricately
sculpt
microbiota
influencing
T2DM-IR.
The
research
illuminated
impact
single
herbal
medicine,
TCM
formulae,
external
therapeutic
methods
such
electroacupuncture
pool
perturbations
structure.
affects
well
sensitivity.
Additionally,
pathways
including
BA-FXR-SHP,
BA-FXR-FGFR15/19,
BA-FXR-NLRP3,
BA-TGR5-GLP-1,
BAs-TGR5/FXR
been
identified
significantly
alter
blood
levels
improve
IR.
These
findings
novel
approaches
for
enhancing
managing
disorders
among
with
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
328, P. 118066 - 118066
Published: March 16, 2024
Gynostemma
pentaphyllum
(Thunb.)
Makino
has
traditional
applications
in
Chinese
medicine
to
treat
lipid
abnormalities.
Gypenosides
(GPs),
the
main
bioactive
components
of
pentaphyllum,
have
been
reported
exert
hypolipidemic
effects
through
multiple
mechanisms.
The
lipid-lowering
GPs
may
be
attributed
aglycone
portion
resulting
from
hydrolysis
by
gut
microbiota.
However,
date,
there
no
reports
on
whether
gypenoside
aglycones
(Agl),
primary
constituents,
can
ameliorate
hyperlipidemia
modulating
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Numerous
studies
have
shown
that
hyperlipidaemia
is
closely
related
to
the
gut
microbiota,
and
study
of
microbiota
in
treatment
undoubtedly
a
new
target
for
prevention
hyperlipidaemia.
The
efficacy
regulating
microecology
changing
structure
flora
has
been
demonstrated
by
both
western
traditional
medication,
biological
therapy,
dietary
exercise,
so
it
particularly
important
relationship
between
In
this
review,
we
summarize
mechanism
pathogenesis
influencing
various
modalities,
which
provides
diversified
therapeutic
ideas
scientific
basis
clinical
treatment.
It
also
triggers
us
think
about
other
diseases,
explore
influence
goal
still
need
explore.
