Highly concentrated collagen/chondroitin sulfate scaffold with platelet-rich plasma promotes bone-exposed wound healing in porcine DOI Creative Commons
Zhihao Li, Qian Li, Akhlaq Ahmad

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 24, 2024

In the case of wounds with exposed bone, it is essential to provide not only scaffolds sufficient mechanical strength for protection, but also environments that are conducive regeneration tissues and blood vessels. Despite excellent biocompatibility biodegradability collagen chondroitin sulfate, they display poor rapid degradation rates. contrast previous methodologies augmented properties biomaterials through incorporation additional substances, this investigation exclusively enhanced collagen/chondroitin sulfate by modulating concentrations. Furthermore, platelet-rich plasma (PRP) was employed establish optimal conditions vascular tissue at wound site. High-concentration (H C-S) were synthesized using high-speed centrifugation combined PRP, their effects on endothelial cell proliferation assessed. A porcine model bone-exposed developed investigate healing mechanisms. The experimental results indicated increased concentration significantly both tensile compressive moduli. combination H C-S PRP markedly promoted proliferation. vivo experiments demonstrated accelerated regeneration. This represents a promising strategy promoting worthy further exploration clinical application.

Language: Английский

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations DOI
Seyed Ebrahim Alavi, Seyed Zeinab Alavi,

Mehr un Nisa

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(3), P. 1056 - 1076

Published: Jan. 30, 2024

Human skin is the largest organ and outermost surface of human body, due to continuous exposure various challenges, it prone develop injuries, customarily known as wounds. Although tissue engineering strategies bioactive wound matrices have been employed speed up healing, scarring remains a significant challenge. The environment harsh presence degradative enzymes elevated pH levels, physiological processes involved in regeneration operate on distinct time scales. Therefore, there need for effective drug delivery systems (DDSs) address these issues. objective this review provide comprehensive exposition mechanisms underlying healing process, factors materials used DDSs, different DDSs care. Furthermore, investigation will delve into examination emergent technologies potential avenues enhancing efficacy care devices.

Language: Английский

Citations

11
Hyaluronic acid hydrogels with excellent self-healing capacity and photo-enhanced mechanical properties for wound healing DOI
Mengfan Zhang, Qi Dong,

Kaidan Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131235 - 131235

Published: March 28, 2024

Language: Английский

Citations

10
Polysaccharides from shell waste of shellfish and their applications in the cosmeceutical industry: A review DOI Creative Commons
Nilesh Prakash Nirmal, Didem Demir, Seda Ceylan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 131119 - 131119

Published: March 22, 2024

Shell waste from shellfish processing contains valuable natural polysaccharides, including sulfated acidic glycosaminoglycans, chitin and their derivatives. These waste-derived polysaccharides have numerous functional biological properties that can be applied in various industries, the cosmeceutical industry. In keeping with global sustainability green industry trends, cosmeceuticals is transitioning petrochemical-based ingredients to substitutes. this context, shell derivatives play a major role as substitutes for petroleum-based components skincare, hair care, oral care body products. This review focuses on presence of discusses applications skin sun indicates utilization will help create circular economy which extracted are used produce

Language: Английский

Citations

9
Dual cross-linked self-healing hydrogel enhanced by dopamine nanoparticles and raffinose for wound healing DOI
Yudie Wang, Hang Gao, Xin Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132615 - 132615

Published: May 23, 2024

Language: Английский

Citations

5
Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds DOI Creative Commons
Yihui Zhang, Jian Kang, Xuan Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 19, 2023

Abstract Background Bacterial infection, complex wound microenvironment and persistent inflammation cause delayed healing scar formation, thereby disrupting the normal function appearance of skin tissue, which is one most problematic clinical issues. Although Ag NPs have a strong antibacterial effect, they tend to oxidize form aggregates in aqueous solution, reduces their efficacy increases toxicity tissues organs. Current research on treatment limited mainly relies growth factors drugs reduce tissue formation. Therefore, there need develop methods that effectively combine drug delivery, antimicrobial anti-inflammatory agents modulate microenvironment, promote healing, prevent scarring. Results Herein, we developed an innovative nanocomposite hydrogel (Ag NCH) by incorporating nanoparticles NPs) into matrix formed linking catechol-modified hyaluronic acid (HA-CA) with 4-arm PEG-SH. The serve dual functions: act as reservoirs for releasing Ag/Ag + at site combat bacterial infections, also cross-linkers ensure sustained release basic fibroblast factor (bFGF). potent effect embedded against S.aureus was validated through comprehensive vitro vivo analyses. microstructural analysis hydrogels studies confirmed NCH possesses smaller pore sizes facilitates slower, more bFGF. When applied acute infected sites, demonstrated remarkable capabilities reshaping immune regenerative microenvironment. It induced shift from M1 M2 macrophage polarization, down-regulated expression pro-inflammatory such IL-6 TNF-α, up-regulated IL-10. Furthermore, played crucial role regulating collagen deposition alignment, promoting formation mature blood vessels, significantly enhancing reconstruction scarless processes. Conclusions We think designed can provide promising therapeutic strategy applications therapy. Graphical

Language: Английский

Citations

12
Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gap, and safety assessment DOI
Shubhrajit Mantry,

Ashutosh Behera,

Shaktiprasad Pradhan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135410 - 135410

Published: Sept. 6, 2024

Language: Английский

Citations

4
Green biosynthesis of titanium dioxide nanoparticles incorporated gellan gum hydrogel for biomedical application as wound dressing DOI Creative Commons
Ying Su,

Xiaoxue Zhu,

Guangqi Xu

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Titanium dioxide nanoparticles (TiO 2 NPs) are widely synthesized chemically for industrial applications. However, these methods often have negative environmental impacts, rendering them unsuitable biomedical Green synthesis approaches offer a promising alternative due to their simplicity, friendliness, and cost-effectiveness. In this study, we report the biosynthesis of TiO NPs using Morus alba leaf extract subsequent incorporation into gellan gum (GG) biopolymer create hydrogel. The physicochemical properties biosynthesized NP@GG hydrogel were characterized Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive (EDS), photoelectron (XPS). Furthermore, bioactivity materials was investigated through antibacterial assays against Staphylococcus aureus Escherichia coli , as well in vitro wound healing studies 3T3 fibroblast scratch assay. XRD analysis confirmed successful formation anatase phase . SEM images revealed presence irregular rod-shaped nanoparticles, with EDS confirming composition oxygen titanium. particle size determined be 80–90 nm, exhibited homogeneous distribution throughout network. displayed significant activity both S. E. assay on cells seeded onto demonstrated high cell survival rate enhanced migration, suggesting potential applications dressing material.

Language: Английский

Citations

0
Oral administration of hyaluronic acid to improve skin conditions via a randomized double‐blind clinical test DOI Creative Commons

Yanrui Gao,

Ruiping Wang,

Lu Zhang

et al.

Skin Research and Technology, Journal Year: 2023, Volume and Issue: 29(11)

Published: Nov. 1, 2023

Abstract Objective To evaluate the impact of oral intake Hyaluronic Acid (HA) on skin health. Background HA, an endogenous substance in human body, plays a key role However, its concentration decreases significantly with age. Previous studies suggested that HA can supplement body's level, but did not reveal effects different age groups and types. Methods A double‐blind, randomized clinical trial 129 female participants, covering young elderly differnet types, was conducted to assess efficacy orally administered Results Oral administration promoted hydration after 2‐8 weeks among both groups. Skin tone improvement observed 4‐8 weeks, while increase epidermal thickness noted 12 weeks. Conclusion This study provides direct evidence supporting promoting

Language: Английский

Citations

10
Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment DOI Creative Commons
Yang Qin, Peng Guo,

Pengkun Lei

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The skin stratum corneum (SC) barrier function will interfere with the absorption of topical treatment and reduce drug's therapeutic effect on alopecia. Microneedles (MNs) can penetrate deliver drugs to dermis. Furthermore, MNs mechanically stimulate skin, which promotes hair growth. Thus, we designed a green dissolvable composite microneedle made hyaluronic acid (HA) Bletilla striata polysaccharide (BSP) encapsulate cholesterol-free ginsenoside Rg3 liposomes (Rg3-LPs) avoid cholesterol metabolism-producing testosterone inhibit regeneration minimize SC absorption. HA BSP enhance mechanical strength Rg3-MNs ensure transport follicle (HF) region while causing minimal irritation guaranteeing cell compatibility. In addition, increased density was more conducive regeneration. telogen effluvium (TE) testosterone-induced androgenetic alopecia (AGA) animals, achieved comparable efficacy minoxidil low-frequency quality regenerated higher. quantitative characterization transcriptome sequencing results showed that promoted by promoting expression Wnt3a Wnt10b genes, activating Wnt/β-catenin pathway. Therefore, present broad prospects in

Language: Английский

Citations

3
Integrating Bioactive Graded Hydrogel with Radially Aligned Nanofibers to Dynamically Manipulate Wound Healing Process DOI

Ruinan Hao,

Xilin Ye,

Xiaofeng Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 37770 - 37782

Published: July 11, 2024

Skin wound healing is a complex process that requires appropriate treatment and management. Using single scaffold to dynamically manipulate angiogenesis, cell migration proliferation, tissue reconstruction during skin great challenge. We developed hybrid platform integrates the spatiotemporal delivery of bioactive cues with topographical wound-healing process. The comprised gelatin methacryloyl hydrogels electrospun poly(ε-caprolactone)/gelatin nanofibers. had graded cross-linking densities were loaded two different functional peptides. nanofibers radially aligned nanofiber array layer random fibers. During early stages healing, KLTWQELYQLKYKGI peptide, which mimics vascular endothelial growth factor, was released from inner hydrogel accelerate angiogenesis. later IKVAVS promotes migration, synergized membrane promote while also supported further proliferation. In an in vivo rat model, significantly accelerated collagen deposition, ratio type I III at site resembled normal skin. prepared regulated regeneration achieve rapid repair clinical application potential, providing strategy for repair.

Language: Английский

Citations

1