Self-Enhanced Ptx@Hsa-Ha Loaded Functionalized Injectable Hydrogel for Effective Local Chemo-Photothermal Therapy in Breast Cancer DOI
Huajian Gao, Hang Li,

Shuaiqiang Shao

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Antibody-drug conjugate combinations in cancer treatment: clinical efficacy and clinical study perspectives DOI Creative Commons
X. Shi, Kai Tang, Quanbin Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

Antibody-drug conjugates have emerged as a promising cancer treatment, combining targeted delivery of cytotoxic agents with the specificity monoclonal antibodies. Despite their potential, ADCs face limitations such resistance and off-target effects. To enhance efficacy, are increasingly being combined other therapeutic strategies, including immune checkpoint inhibitors, chemotherapy, small-molecule anti-angiogenic agents, CAR-T cell therapies. These combination therapies aim to overcome mechanisms, improve tumor targeting, boost responses. Clinical studies shown that combinations can significantly response rates progression-free survival across various cancers. This review explores clinical key studies, challenges, future perspectives in therapy.

Language: Английский

Citations

0
Recent advances in nano-molybdenum oxide for photothermal cancer therapy DOI

S Chen,

Ping Zhang,

Hongmei Bai

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: March 10, 2025

Cancer remains a significant global health challenge, driving the search for innovative treatments. Photothermal therapy (PTT) has emerged as promising approach, using photothermal agents to convert near-infrared (NIR) light into heat tumor ablation. Among these agents, nano-molybdenum oxide, particularly non-stoichiometric MoO3-x (0 < x 1), stands out due its unique defect structure, strong NIR absorption, high conversion efficiency (PCE), and pH-responsive degradation. This review summarized recent advancements in oxide PTT, covering classification, synthesis, surface modification, tumor-targeting mechanisms. Subsequently, we explored applications PTT combination therapies, evaluated biocompatibility toxicity, discussed current achievements, challenges, future perspectives cancer treatment.

Language: Английский

Citations

0
Optimization of Cancer Immunotherapy Through Synergistic Enhancement of Immunogenic Cell Death by Multifunctional Nanobioreactors Combined with Immune Checkpoint Inhibitors DOI
Hui Zhang, Chunyu Qu, Ziqing Yang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
Metallized hollow-COF nanobowls with dual-mode ROS generation for cancer sonodynamic therapy DOI

Donghan Shao,

Xinyu Pei,

Yuqin Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

An iron-metallized hollow COF nanobowl (FeHHCA) was synthesized for cancer sonodynamic therapy.

Language: Английский

Citations

0
A self-assembly active nanomodulator based on berberine for photothermal immunotherapy of breast cancer via dual regulation of immune suppression DOI
Jiang Sun,

Tingxian Ye,

Xinxin Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123898 - 123898

Published: Feb. 11, 2024

Language: Английский

Citations

3
Co-assembly of cisplatin and dasatinib in hyaluronan nanogel to combat triple negative breast cancer with reduced side effects DOI

Runmeng Liu,

Wei Hou, J. Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132074 - 132074

Published: May 3, 2024

Language: Английский

Citations

3
Self-enhanced PTX@HSA-HA loaded functionalized injectable hydrogel for effective local chemo-photothermal therapy in breast cancer DOI
Huajian Gao, Hang Li,

Shuaiqiang Shao

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 345, P. 122569 - 122569

Published: Aug. 2, 2024

Language: Английский

Citations

3
Stimuli-Responsive Prodrugs with Self-Immolative Linker for Improved Cancer Therapy DOI

Xu Wenting,

Ang Jia,

Zhixian Lei

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116928 - 116928

Published: Sept. 30, 2024

Language: Английский

Citations

3
Application of hyaluronic acid-based nanoparticles for cancer combination therapy DOI
Mengru Yang, Ying Zhang,

Zheming Hu

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 646, P. 123459 - 123459

Published: Sept. 29, 2023

Language: Английский

Citations

8
Hyaluronic acid application strategies for plant bioactive component delivery: A review DOI
Ailin Zhang,

John Huang,

Yutong Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137129 - 137129

Published: Oct. 31, 2024

Language: Английский

Citations

2