Flexible sodium alginate-gelatin hydrogel membrane incorporated with green synthesized bimetallic ZnO:CeO2 nanocomposite for antioxidant, antibacterial and biocompatibility studies

Reactive and Functional Polymers, Journal Year: 2025, Volume and Issue: 212, P. 106228 - 106228

Published: Feb. 27, 2025

Language: Английский

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Composition and layered co-continuous structure co-regulate shape memory properties

International Journal of Mechanical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 110187 - 110187

Published: March 1, 2025

Language: Английский

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Solvent casting-salt leaching synthesis, characterization, and biocompatibility of three-dimensional porous chitosan/nano-hydroxyapatite scaffolds for bone tissue engineering

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Mechanical and biological properties of 3D printed bone tissue engineering scaffolds

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Bone defects have historically represented a significant challenge in clinical practice, with traditional surgical intervention remaining the gold standard for their management. However, due to problem of origin autologous and allogeneic bone complex diverse defects, methods sometimes cannot meet treatment needs expectations patients. The development tissue engineering 3D printing technology provides new ideas defect repair. Ideal bioscaffold materials must good mechanical properties, biocompatibility, osteoinduction conduction capabilities. Additionally, factors such as degradation rate, appropriate porosity sustained antibacterial effect be taken into account. combination synthetic composite biomaterial scaffolds has become well-established approach offering innovative solutions combined application seed cells, signalling biological is also beneficial improve therapeutic defects. This article will therefore examine some most commonly used technologies prevalent suitable printing. An analysis conducted on properties these elucidate respective advantages limitations.

Language: Английский

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Recent advances and future prospects of nano-engineered bone cements: A state-of-the-art review

Composites Part A Applied Science and Manufacturing, Journal Year: 2025, Volume and Issue: unknown, P. 108991 - 108991

Published: May 1, 2025

Language: Английский

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Development of a highly porous bioscaffold by the combination of bubble entrapping and freezing-thawing techniques to fabricate hyaluronic acid/gelatin tri-layer wound dressing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129206 - 129206

Published: Jan. 21, 2024

Language: Английский

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Biopolymeric Scaffolds with Melatonin for Tissue Engineering—A Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2520 - 2520

Published: March 11, 2025

Melatonin, a natural hormone with antioxidant, anti-inflammatory, and regenerative properties, has gained increasing attention in tissue engineering for its ability to enhance the therapeutic potential of biopolymeric scaffolds. These scaffolds, designed mimic extracellular matrix, provide structural support bioactive environment regeneration. By integrating melatonin, researchers aim create multifunctional scaffolds that promote cell proliferation, modulate inflammatory responses, improve wound healing outcomes. Challenges utilizing melatonin include maintaining stability under light, heat, oxygen exposure, optimizing release profile sustained effects. Innovative fabrication methods, such as electrospinning, 3D printing, lyophilization, have enabled precise control over scaffold architecture delivery. techniques ensure enhanced interactions target tissues tailored regeneration processes. Combining growth factors, cytokines, antimicrobial agents offers applications, from chronic management bone nerve Continued research this field promises transformative solutions medicine, expanding clinical applicability melatonin-enriched This review highlights current progress, challenges, opportunities associated harnessing melatonin’s within frameworks.

Language: Английский

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Bone-Regenerating Capacity of Chitosan Membrane and Chitosan Foam Scaffolds in Critical Size Defects: In Vitro and In Vivo Study

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(4), P. 153 - 153

Published: March 31, 2025

Objectives: The objective of this study is to compare the bone-regenerating capacity between chitosan foam and membrane scaffolds. Methods: A medium-weight acidic mixture was used prepare two scaffolds freeze-dried (CF). One CF physically crosslinked by NaHCO3 obtain (CM). morphological assessment specimens’ porosity carried out scanning electron microscopy (SEM). An MTT assay CM specimens using rats’ bone marrow mesenchymal stem cells (MSCs) out. Then, 38 albino rats were subjected surgical implantation in a critical-size defect femur bone. divided into three groups according type implanted scaffold (Control (no scaffold) n = 10, (chitosan membrane) 14, foam) 14). Each group equally subdivided subgroups time euthanasia (21 d, 35 d). bones dissected for histological analysis (hematoxylin eosin, Masson trichrome). results graded scoring system. statistical pore size grading Results: had higher mean (65.42 µm) compared (6.44 µm); showed significantly proliferation MSCs at 72 h. Both regeneration lower inflammation than control group. score group, especially d with more dense compact lamellar structure. Conclusions: allowed regenerating CM.

Language: Английский

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Investigation of Biodegradation and Biocompatibility of Chitosan–Bacterial Cellulose Composite Scaffold for Bone Tissue Engineering Applications

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 723 - 723

Published: May 15, 2025

Developing scaffolds with a three-dimensional porous structure and adequate mechanical properties remains key challenge in tissue engineering of bone. These must be biocompatible biodegradable to effectively support osteoblastic cell attachment, metabolic activity, differentiation. This study successfully fabricated chitosan-bacterial cellulose (CS-BC) composite scaffold using the solvent casting/particle leaching (SCPL) technique, NaOH/urea solution sodium chloride crystals as porogen. The exhibited well-distributed network pore sizes ranging from 300 500 µm. Biodegradation tests PBS containing lysozyme revealed continuous degradation process, while vitro studies MC3T3-E1 cells (pre-osteoblastic mouse line) demonstrated excellent observed through SEM imaging. also promoted increased activity (OD values) MTT assay, enhanced alkaline phosphatase (ALP) upregulated expression osteogenic-related genes. findings suggest that CS-BC scaffold, SCPL method, holds great potential candidate for bone applications.

Language: Английский

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Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of Therapeutics and Bone Regeneration: An Overview of Recent Advances and Progresses

Current Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(15), P. 1190 - 1214

Published: May 15, 2024

Abstract: The usage of nanoparticles in tissue engineering applications has increased significantly the last several years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on nanostructured scaffolds containing cells. These provide an environment that is more structurally supportive than microarchitecture natural bone. Given its exceptional properties, such as osteogenic potential, biocompatibility, biodegradability, chitosan a good promising biomaterial. Unfortunately, chitosan's low mechanical strength makes it unsuitable for load-bearing applications. By mixing with other biomaterials, this drawback might be mitigated. Bone uses both bioresorbable materials like tricalcium phosphate bioactive hydroxyapatite bioglass. Alumina titanium examples bioinert part these bioceramics. When produced at nanoscale scales, have larger surface area better adhesion. This review paper will go into great detail bioinert, bioresorbable, nanoceramics-reinforced bone engineering.

Language: Английский

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