The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect DOI Open Access
Ehsan Aliabadi,

Mohammad Mehdi Farahmand,

Tahereh Talaei‐Khozani

et al.

Galen Medical Journal, Journal Year: 2023, Volume and Issue: 12

Published: Dec. 17, 2023

Background: Thymoquinone (TQ) has some beneficial roles in bone repair. Local administration of the drugs by loading them into a scaffold leads to releasing higher concentrations drug appropriate position. This study was conducted evaluate effects local TQ loaded an alginate on regeneration rabbit mandibular defect. Materials and Methods: In this experimental study, male rabbits with mandible defect were divided 3 groups that received either containing 50µM TQ, or remained untreated. Then each group subdivided 2 followed for 4 8 weeks (n=5). The radiological opacity, histopathology, histomorphometrical analysis done data analyzed ANOVA Tukey. Results: Radiological examination indicated presence had no significant effect turbidity images (P=0.595). treatment significantly increased area after (P=0.011, P=0.0021, respectively) (8w P=0.019, P<0.001, compared alginate-treated control defects. also elevated number osteocytes (4wP<0.001, P=0.001 8w osteoblasts (P<0.001, receiving control. However, at weeks, statistically similar all groups. week, although average defects treated than (P=0.01), it alginate. Conclusion: It seems positive healing. can be suggested as good additive improve healing accelerate

Language: Английский

β-Tricalcium phosphate incorporated natural rubber latex membranes for calvarial bone defects: Physicochemical, in vitro and in vivo assessment DOI
Karina Giovanetti, Roman Tůma, Giovana Sant’Ana Pegorin Brasil

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137328 - 137328

Published: Nov. 6, 2024

Language: Английский

Citations

2
Insights into the Various Cellular Antimicrobial Responses, Biocompatibility, Osteogenesis, Wound Healing, and Angiogenesis of Copper-Doped Nano-Hydroxyapatite Composite Calcium Phosphate Bone Cement In Vitro DOI Open Access

Ssu-Meng Huang,

Wen‐Cheng Chen,

Shih-Ming Liu

et al.

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(10), P. 424 - 424

Published: Oct. 14, 2024

Calcium phosphate bone cement (CPC) is a popular material for remodeling, and nanohydroxyapatite (nHA) represents breakthrough that has wide range of clinical applications. During the early stages repair, antibacterial angiogenesis effects are essential to remodel new tissues. In this study, an effect was achieved by incorporating Cu2+-doped nano-hydroxyapatite (Cu–nHA) synthesized through hydrothermal methods into CPC, impact various amounts Cu–nHA addition on mechanical properties CPC hybridization evaluated. Moreover, Cu–nHA/CPC composites proliferation mineralization mouse progenitor osteoblastic cells (D1 cells) were characterized; cell migration ability vascular endothelial (HUVECs) also studied. Results indicated 5 wt.% 10 led practical short-term S. aureus but not E. coli. These slurries remained injectable, anti-disintegrative, non-toxic. Furthermore, compared with pure these demonstrated positive D1 cells, resulting in better mineralization. addition, more effective promoting HUVECs. findings indicate great application potential regeneration.

Language: Английский

Citations

0
The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect DOI Open Access
Ehsan Aliabadi,

Mohammad Mehdi Farahmand,

Tahereh Talaei‐Khozani

et al.

Galen Medical Journal, Journal Year: 2023, Volume and Issue: 12

Published: Dec. 17, 2023

Background: Thymoquinone (TQ) has some beneficial roles in bone repair. Local administration of the drugs by loading them into a scaffold leads to releasing higher concentrations drug appropriate position. This study was conducted evaluate effects local TQ loaded an alginate on regeneration rabbit mandibular defect. Materials and Methods: In this experimental study, male rabbits with mandible defect were divided 3 groups that received either containing 50µM TQ, or remained untreated. Then each group subdivided 2 followed for 4 8 weeks (n=5). The radiological opacity, histopathology, histomorphometrical analysis done data analyzed ANOVA Tukey. Results: Radiological examination indicated presence had no significant effect turbidity images (P=0.595). treatment significantly increased area after (P=0.011, P=0.0021, respectively) (8w P=0.019, P<0.001, compared alginate-treated control defects. also elevated number osteocytes (4wP<0.001, P=0.001 8w osteoblasts (P<0.001, receiving control. However, at weeks, statistically similar all groups. week, although average defects treated than (P=0.01), it alginate. Conclusion: It seems positive healing. can be suggested as good additive improve healing accelerate

Language: Английский

Citations

0