Published: Jan. 1, 2024

Microneedle array (MNA) represent a promising advancement in transdermal drug delivery for the treatment of skin diseases, yet effective penetration keloid tissue poses significant challenges due to its tougher texture. In this study, we fabricated new drug-loaded MNA utilizing fused deposition modeling (FDM) 3D printing technology and composites consisting polylactic acid (PLA) chemically treated river snail shell powder (CRSSP). Mechanical, thermal, properties, cell compatibility were systematically evaluated. Finite element analysis (FEA) was employed optimize design, followed by puncture experiments assess efficacy. Results revealed that 0.2 CRSSP/PLA exhibited superior tensile flexural strength, with enhancements 17.94% 29.65% compared PLA alone, respectively. Furthermore, demonstrated favorable printability sixfold improvement performance PLA. FEA simulations confirmed ability composite effectively uniformly penetrate tissue. This novel from via holds clinical potential facilitating efficient percutaneous delivery.

Language: Английский