Stimuli-responsive peptide hydrogels for biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1748 - 1774

Published: Jan. 1, 2024

This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications.

Language: Английский

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A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 562 - 581

Published: May 30, 2024

Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present novel hydrogel patch (SCE2) composed biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying straightforward local method initiates formation barrier adheres to mucosal injuries under influence ultraviolet light. SCE2 then demonstrates exceptional capabilities for near-infrared photothermal sterilization neutralization reactive oxygen species. These properties contribute elimination bacteria management oxidation process, thus accelerating healing phase's progression inflammation proliferation. In studies involving diabetic rats ulcers, adhesive significantly quickens recovery by altering inflamed state injured area, facilitating rapid re-epithelialization, fostering angiogenesis. conclusion, this light-sensitive offers promising path expedited wound healing, potentially transforming treatment strategies clinical ulcers.

Language: Английский

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Advances in chitosan-based blends as potential drug delivery systems: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132916 - 132916

Published: June 5, 2024

Language: Английский

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Small functional hydrogels with big engineering applications

Materials Today Physics, Journal Year: 2024, Volume and Issue: 43, P. 101397 - 101397

Published: March 19, 2024

Language: Английский

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Stimuli-responsive hydrogel based on natural polymers for breast cancer

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 18, 2024

Aims: Breast cancer is the most common malignancy among women in both high- and low-resource settings. Conventional breast therapies were inefficient had low patient compliance. Stimuli-responsive hydrogels possessing similar physicochemical features as soft tissue facilitate diagnostic therapeutic approaches for subtypes. Scope: Polysaccharides polypeptides are major natural polymers with unique biocompatibility, biodegradability, feasible modification utilized frequently hydrogel fabrication. Alternating polymer-based properties response to external stimuli such pH, temperature, light, ultrasonic, enzyme, glucose, magnetic, redox, electric have provided great potential evolution of novel drug delivery systems (DDSs) various advanced technologies medical applications. triggered by specific features, promote target techniques, modify release agents at localized sites. This narrative review presented innovation preparing characterizing stimuli-responsive applications area. Conclusion: display bioinspiration products DDSs subtypes, protect shape tissue, provide modified release, enhance efficacy, minimize chemotherapy agents’ side effects. The benefits smart make them an exciting area practice diagnosis treatment.

Language: Английский

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Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5359 - 5359

Published: May 14, 2024

Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral parenteral dosage forms because it increases bioavailability reduces systemic toxicity. The mucosa has a good blood supply, which ensures that molecules enter the circulation directly, avoiding metabolism during first passage through liver. At same time, number of barriers, including mucus, epithelium, enzymes, immunocompetent cells, are designed prevent entry foreign substances into body, also complicates absorption drugs. development oromucosal delivery systems based on mucoadhesive biopolymers their derivatives (especially thiolated catecholated derivatives) promising strategy for pharmaceutical safe forms. Solid, semi-solid liquid formulations have several advantageous properties, such as prolonged residence time due high mucoadhesion, unidirectional modified release capabilities, enhanced permeability. Biopolymers non-toxic, biocompatible, biodegradable may possess intrinsic bioactivity. A rational approach design requires understanding anatomy/physiology physicochemical biopharmaceutical properties molecule/biopolymer, presented in this review. This review summarizes advances (e.g., patches, buccal tablets, hydrogel systems), nanotechnology-based biopolymer nanoparticle solid lipid particles, liposomes, polyelectrolyte hybrid nanoparticles, etc.).

Language: Английский

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Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393

Published: June 24, 2024

Language: Английский

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Exploring the potential and safety of quantum dots in allergy diagnostics

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Nov. 17, 2023

Biomedical investigations in nanotherapeutics and nanomedicine have recently intensified pursuit of new therapies with improved efficacy. Quantum dots (QDs) are promising nanomaterials that possess a wide array advantageous properties, including electronic optical engineered biocompatibility under physiological conditions. Due to these characteristics, QDs mainly used for biomedical labeling theranostic (therapeutic-diagnostic) agents. can be functionalized ligands facilitate their interaction the immune system, specific IgE, effector cell receptors. However, undesirable side effects such as hypersensitivity toxicity may occur, requiring further assessment. This review systematically summarizes potential uses allergy field. An overview definition development is provided, along applications studies, detection allergen-specific IgE (sIgE), food allergens, sIgE cellular tests. The treatment allergies also described, highlighting nanodevices. Finally, we discuss current findings on immunotoxicity QDs. Several favorable points regarding use diagnosis noted.

Language: Английский

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Preparation of pH-sensitive alginate-based hydrogel by microfluidic technology for intestinal targeting drug delivery

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127649 - 127649

Published: Nov. 7, 2023

Language: Английский

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Collagen/gelatin and polysaccharide complexes enhance gastric retention and mucoadhesive properties

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131034 - 131034

Published: March 20, 2024

Language: Английский

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