Preparation and Characterization of Biodegradable Polyester/Natural Protein Electrospun Nanofiber with Wound Healing Activity

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Abstract The protein from black soldier fly larvae was used as a functional ingredient of new fiber composite for wound scaffolding. Larvae powder (LP) blended with biodegradable poly(ε-caprolactone) (PCL) and processed in an electrospinning machine using coaxial feeding/mixing method to produce nanofibers approximately 100–350 nm diameter. To improve the dispersion interface bonding various PCL/LP nanofiber components, homemade compatibilizer, maleic anhydride-grafted (MPCL), added form MPCL/LP nanofibers. structure, morphology, mechanical properties, water absorption, biocompatibility, healing, biodegradability mats were investigated. results showed enhanced adhesion compared mats; additionally, exhibited better tensile strength at break 0.7–2.2 Young's modulus 9.0–22.8 MPa. Decomposition tests simulated body fluid revealed that addition LP decomposition rate both vitro release. Cell proliferation migration analysis indicated PCL, MPCL, their composites biocompatible fibroblast (FB) growth. Cell-cycle assays conducted by FBs on samples normal cell growth distribution 30-day soil test. When content 20 wt.%, degradation exceeded 50%. This suggests potential these materials scaffold material novel green environmental pollution reduction.

Language: Английский

---

Bioactive nanofibrous mats constructs: Separate efficacy of Lawsonia inermis and Scrophularia striata extracts in PVA/alginate matrices for enhanced wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134545 - 134545

Published: Aug. 6, 2024

Language: Английский

---

Chitosan and PVP: Versatile Biopolymers for Drug Delivery and Advanced Materials

Bionatura journal :, Journal Year: 2024, Volume and Issue: 1(3), P. 1 - 23

Published: Sept. 15, 2024

Chitosan (CS) is one of the most studied natural polymers in biomaterials because its extraction from exoskeletons crustaceans such as shrimp and crabs not too complex or expensive. Additionally, this polysaccharide has hydroxyl primary amino functional groups structure, making it particularly useful for interacting with other compounds, mainly acidic media. Polyvinylpyrrolidone (PVP), like chitosan, antibacterial properties biocompatibility living tissue, which made these two biopolymers object study development new materials desired design drug delivery systems (DDS). Both can form films gels; however, advantage PVP compared to CS solubility water. Another essential feature their ability complexes synthetic drugs products, makes them especially DDS. This review presents main characteristics addresses possibility combining develop DDS that provide individual improve physical, chemical, biological properties. Keywords: chitosan (CS), polyvinylpyrrolidone (DDS), biomaterials.

Language: Английский

---

Evaluation of Moringa oleifera Incorporated With Zinc Oxide Nanoparticles/Poly(Vinyl) Alcohol Nanofibers as Antibacterial Material

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

ABSTRACT Antibacterial materials are increasingly significant, particularly for biomaterials and food packaging applications. Materials with good elasticity antibacterial properties crucial in this line of work. This study focused on the investigation nanofiber by combining Moringa oleifera (MO) zinc oxide nanoparticles (ZnO NPs) polyvinyl alcohol (PVA) nanofiber. The PVA/MO/ZnO is fabricated using electrospinning method. morphology shows smooth uniform fibers 292 nm diameter size. EDX mapping also demonstrates successful loading ZnO NPs into fibers, tensile test gives modulus Young as 290 MPa, which corresponds to or flexibility biomedical activity mats against gram‐positive gram‐negative microbial species a inhibition zone 6.84 mm Escherichia coli bacteria. hydrophilicity nanofibers supported activity. These results show that certainly potential material has properties, may be useful biomaterial applications, packaging, coating material. It suggested simple preparation an elasticity.

Language: Английский

---

Dental implants coated with BMP-2- and α-tocopherol-loaded nanofibers enhance osseointegration

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125136 - 125136

Published: Dec. 1, 2024

Language: Английский

---