Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155219 - 155219

Published: Feb. 16, 2024

Language: Английский

Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review

Journal of Prevention Diagnosis and Management of Human Diseases, Journal Year: 2024, Volume and Issue: 42, P. 39 - 52

Published: March 9, 2024

Kidney injury, a global health challenge, necessitates nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge pivotal players in orchestrating renal health. Dysregulation specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 MALAT1 regulate apoptosis, inflammation, fibrosis. Chronic disease (CKD) involves H19 modulating cell proliferation apoptosis. Beyond diagnostics, actively shape fibrosis, positioning them master regulators the intricate ballet Recent strides research, coupled with cutting-edge genomics bioinformatics tools, highlight their roles therapeutic potential. Challenges interactions necessitate exploration promising avenues, including single-cell RNA sequencing artificial intelligence, paving way personalized interventions regenerative medicine diseases.

Language: Английский

METRNL exerts cytoprotective effects on EPCs via regulation of the E2F1-TXNIP axis in obese limb ischemia

Cellular Signalling, Journal Year: 2024, Volume and Issue: unknown, P. 111528 - 111528

Published: Nov. 1, 2024

Language: Английский