Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141377 - 141377
Published: Feb. 1, 2025
Language: Английский
Citations
4Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 47 - 47
Published: Jan. 19, 2025
Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate anti-inflammatory activity underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), compound derived from marine organisms, especially IBD, using zebrafish model. The results indicated that MBD could inhibit inflammatory responses induced CuSO4, tail amputation LPS zebrafish. Furthermore, notably inhibited intestinal migration immune cells, enhanced integrity gut mucosal barrier improved peristalsis function IBD model trinitro-benzene-sulfonic acid (TNBS). In addition, ROS elevation TNBS. Network pharmacology analysis, molecular docking, transcriptomics sequencing RT-PCR were conducted investigate potential mechanism. showed regulate TLR/NF-κB pathways inhibiting mRNA expression TNF-α, NF-κB, IL-1, IL-1β, IL6, AP1, IFNγ, IKKβ, MyD88, STAT3, TRAF1, TRAF6, NLRP3, NOD2, TLR3 TLR4, promoting IL4, IκBα Bcl-2. conclusion, these findings indicate be candidate for treatment IBD.
Language: Английский
Citations
0Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102676 - 102676
Published: April 1, 2025
Language: Английский
Citations
0Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106267 - 106267
Published: Oct. 8, 2024
Language: Английский
Citations
2Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105450 - 105450
Published: Nov. 12, 2024
Language: Английский
Citations
1Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23
Published: Jan. 1, 2024
Language: Английский
Citations
0Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1231 - 1253
Published: Jan. 1, 2024
Language: Английский
Citations
0Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0