Expression patterns of housekeeping genes and tissue-specific genes in black goats across multiple tissues DOI Creative Commons
Chaobin Qin, Dong Wang, Hongbing Han

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 19, 2024

Language: Английский

LncRNA SNHG1 regulates muscle stem cells fate through Wnt/β‐catenin pathway DOI Open Access
Changying Wang, Wenwen Wu, Junyi Chen

et al.

Developmental Dynamics, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Background Skeletal muscle stem cells (MuSCs) played an important role in maintaining the proper function of tissues. In adults, they normally remained a quiescent state and activated upon stimulation to undergo self‐renewal or myogenic differentiation. This process was complexly regulated by cytokines, molecular mechanisms that promoted MuSCs activation largely unknown. Results Here, we analyzed transcriptome data from different stimuli using weighted gene co‐expression network analysis (WGCNA) identified key long non‐coding RNA SNHG1 (lncSNHG1), which promotes transition MuSCs. Overexpression lncSNHG1 able promote proliferation differentiation MuSCs, whereas knockdown resulted opposite results. Mechanistically, disruption Wnt/β‐catenin pathway blocked quiescence exit induced lncSNHG1. Conclusions We conclude is factor cell through pathway.

Language: Английский

Citations

0
MAZ-induced lncRNA H19 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via sponge miR-935/miR-296-5p and the p38 MAPK pathway DOI
Quan Liu, Honghong Zhou,

Chong Fu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142675 - 142675

Published: March 1, 2025

Language: Английский

Citations

0
Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells DOI Creative Commons

Shujing Feng,

Hao Zhou, Xingzuan Lin

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 4, 2024

Abstract Background Exercise exerts positive impacts on skeletal muscle health and homeostasis. Emerging evidence suggests that m6A methylation is involved in various physiological processes. However, the impact of exercise adolescent growth underlying epigenetic mechanisms remain poorly understood. Methods The lower-limb muscles were harvested from control groups to compare adolescents. mRNA sequencing was conducted explore enhanced following exercise. effects Mettl3-mediated investigated using satellite cell (MuSC)-specific Mettl3 knockout (KO) mice. potential function MyoD for adolescents explored by phenotypes after overexpression evaluation vivo myogenesis. Additionally, methyl donor betaine vitro vivo. Results could promote Sequencing data analysis confirmation assays uncovered significantly increased elevated expression levels activation marker MuSCs. Establishment MuSC-specific KO mice further demonstrated contributed during adolescence. regulated stability at posttranscriptional level MuSCs, with a functional site 234 bp A. Increased contribute myogenesis Furthermore, enhance expression, contributing MuSCs boosting levels. Conclusions promoted through facilitating m6A-dependent manner. be alternative promoting directly augmenting global methylation. These findings may provide theoretical foundation encouraging daily fitness ensuring healthy

Language: Английский

Citations

2
Expression patterns of housekeeping genes and tissue-specific genes in black goats across multiple tissues DOI Creative Commons
Chaobin Qin, Dong Wang, Hongbing Han

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 19, 2024

Language: Английский

Citations

1