Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 148 - 161
Published: Nov. 20, 2024
Language: Английский
Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 188 - 188
Published: March 8, 2024
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements an ideal wound dressing, making them promising for care. These features include, among others, the ability to absorb and retain large amounts water capacity closely mimic native structures, such as extracellular matrix, facilitating cellular processes like proliferation differentiation. The polymers used in hydrogel formulations exhibit broad spectrum properties, allowing be classified into two main categories: natural collagen chitosan, synthetic polyurethane polyethylene glycol. This review offers comprehensive overview critical analysis key can constitute hydrogels, beginning with brief contextualization polymers. It delves their function, origin, chemical structure, highlighting sources extraction obtaining. Additionally, this encompasses intrinsic properties these roles healing process, accompanied, whenever available, by explanations underlying mechanisms action. also addresses limitations describes some studies on effectiveness isolated promoting skin regeneration healing. Subsequently, we briefly discuss application strategies hydrogels derived from potential promote process. achieved due role stimulation angiogenesis, example, or through incorporation substances growth factors drugs, antimicrobials, imparting new hydrogels. In addition substance incorporation, is related serve three-dimensional matrix cell culture, whether it involves loading cells recruiting site, where they proliferate scaffold form tissue. latter strategy presupposes biosensors real-time monitoring conditions, temperature pH. Future prospects then ultimately addressed. As far aware, manuscript represents first approach brings together critically analyzes fundamental aspects both constituting context cutaneous will foundational point future studies, aiming contribute development effective environmentally friendly dressing wounds.
Language: Английский
Citations
32
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132411 - 132411
Published: May 31, 2024
Language: Английский
Citations
15
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139952 - 139952
Published: Jan. 1, 2025
Language: Английский
Citations
1
ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(13), P. 7393 - 7407
Published: June 27, 2024
In recent years, there has been an increasing interest in the use of biomass-based nanocomposite hydrogels for wearable flexible sweat sensors. this manuscript, design a dual-network hydrogel using sodium carboxymethyl cellulose (CMC-Na) to develop high-performance sensor is considered be effective method accurate monitoring human movement and continuous noninvasive measurement glucose levels sweat. The gel gauge factor (GF) 1.34 toughness 4.18 MJ/m3, exhibiting excellent mechanical properties self-healing capabilities (92.6%). As motion sensor, it can accurately identify various movements. By incorporating oxidase-thioglycolic acid-gold nanoparticles (GTAN) nanomaterials into hydrogel, stable electrocatalytic activity was achieved. detection limit (LOD) 0.28 μM wide operating range. Additionally, different testing methods show good linear relationships, indicating sensor's universality measurement. analyzing daily physical activities sweat, individual health achieved, thereby expanding potential next-generation multifunctional sensing systems.
Language: Английский
Citations
4
ACS Omega, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Skin is the first defense barrier of human body, which can resist invasion external dust, microorganisms and other pollutants, ensure that body maintains homeostasis internal environment. Once skin damaged, health threat to will increase. Wound repair environment are a dynamic process. How effectively accelerate healing wounds without affecting guarantee repaired tissue retains its original function as much possible has become research hotspot. With advancement technology, researchers have combined new technologies develop prepare various types materials for wound healing. This article introduce developed prepared in recent years from three types: nanofibers, composite hydrogels, materials. The paper aims provide reference related fields multifunctional may be helpful design more ideal clinical application, then achieve better regeneration effects.
Language: Английский
Citations
4
APL Materials, Journal Year: 2025, Volume and Issue: 13(2)
Published: Feb. 1, 2025
Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated recombinant type I collagen (rColMA) and ε-poly(L-lysine)-methacrylamide (EPLMA), providing excellent antibacterial properties. In addition, encapsulated interleukin-6-loaded liposomes (IL-6@Lip) are incorporated into the to further promote regeneration. innovative design creates an optimal microenvironment growth differentiation bone marrow mesenchymal stem cells (BMSCs) duct-like cells. These differentiated contribute regeneration, evidenced by expression key markers, including CK7, CK19, AQP1, AE2, CX43. rColMA/EPLMA/IL-6@Lip hydrogel in significantly enhances BMSC proliferation their epithelial Furthermore, vivo experiments show that PCLMA//rColMA/EPLMA/IL-6@Lip does not induce stasis. novel, pre-differentiated active offers valuable insights regeneration replacement research.
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 31, 2025
Skin microecology involves a dynamic equilibrium among the host, microbiome, and internal/external environments. This equilibrium, shaped by multifactorial interactions, reflects individual specificity diversity. Creating replicable in vitro skin microecological model is highly challenging. Here, we introduce mimicked stratum corneum (SCmic). It uses light cured crosslinked hydrogels as scaffold moisture source, nonviable epidermal cells main nutrient. setup establishes suitable, stable, reproducible for microbiome colonization. Notably, it replicates normal/oily microbiota with no significant differences from original native at genus level. Simultaneously, have developed standardized human (Hcm), featuring seven dominant strains that form representative microbial community. The models provide convenient approaches exploring intricate mutual interactions microecology, influence of on health, metabolism chemical substances microbiota. Effective are needed to reduce animal testing. authors report an using hydrogel-based supports stable growth, resembling natural communities, allowing study metabolism.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4009 - 4009
Published: April 24, 2025
Tissue engineering techniques aim to improve or replace biological tissues organs by utilizing the extracellular matrix facilitate repair of damaged organs. Collagen-based scaffolds offer numerous advantages, including excellent biocompatibility, low immunogenicity, biodegradability, hemostatic properties, and mechanical strength. Collagen can reconstruct microenvironment, promote cell adhesion, migration, proliferation, differentiation, play a critical role in cell-to-cell cell-to-matrix interactions. has been extensively utilized tissue organ reconstruction. This review examines properties collagen, its composition, structure, characteristics, regulating various cellular behaviors. Additionally, preparation cell-loaded collagen is discussed, along with comprehensive overview their applications tissues, skin, nerve, bone/cartilage, heart, liver, others. Emerging strategies future perspectives for clinical are also presented. provides synthesis mechanisms underlying use as advanced biomaterials, emphasizing potential expand collagen.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163134 - 163134
Published: April 1, 2025
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1287 - 1287
Published: May 7, 2025
Digital light processing (DLP) technology stands out as a groundbreaking method in the field of biomedical engineering that enables production highly precise structures using photopolymerizable materials. Smart materials such shape memory polymers, hydrogels, and nanocomposites are used ideal for personalized medicine applications thanks to their properties superior mechanical strength, biocompatibility, sensitivity environmental stimuli DLP technology. The integration these with functional complex structures, especially areas bone soft tissue engineering, drug delivery, biosensor production. However, limited material diversity, scalability problems processes, technical difficulties optimizing bioprinting parameters among main obstacles this field. This study systematically examines role smart biomaterials DLP-based processes. It addresses innovative regenerative medicine. also comprehensively evaluates its contributions discusses future research overcome current limitations.
Language: Английский
Citations
0