Localized Delivery of Healing Stimulator Medicines for Enhanced Wound Treatment

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106212 - 106212

Published: Sept. 1, 2024

Language: Английский

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Vanillin and IGF1-loaded dual-layer multifunctional wound dressing with micro-nanofibrous structure for full-thickness wound healing acceleration

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 671, P. 125231 - 125231

Published: Jan. 15, 2025

Language: Английский

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Chitosan-based injectable porous microcarriers with enhanced adipogenic differentiation and angiogenesis for subcutaneous adipose tissue regeneration

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214174 - 214174

Published: Jan. 5, 2025

Language: Английский

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Leveraging the predictive power of a 3D in vitro vascularization screening assay for hydrogel-based tissue-engineered periosteum allograft healing

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214187 - 214187

Published: Jan. 16, 2025

Language: Английский

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Antibacterial and wound healing stimulant nanofibrous dressing consisting of soluplus and soy protein isolate loaded with mupirocin

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 2, 2024

Abstract Severe cutaneous injuries may not heal spontaneously and necessitate the use of supplementary therapeutic methods. Electrospun nanofibers possess high porosity specific surface area, which provide necessary microenvironment for wound healing. Here in, Soluplus-soy protein isolate (Sol-SPI) containing mupirocin (Mp) were fabricated via electrospinning treatment. The exhibited water absorption capacities about 300.83 ± 29.72% vapor permeability values 821.8 49.12 g/m 2 day. Sol/SPI/Mp showed an in vitro degradability 33.73 3.55% after 5 days. ultimate tensile strength, elastic modulus, elongation measured as 3.61 0.29 MPa, 39.15 5.08 59.11 1.94%, respectively. Additionally, 85.90 6.02% Mp loaded was released days vitro, by applying Mp-loaded nanofibers, 93.06 5.40% 90.40 5.66% S. aureus E. coli bacteria killed, Human keratinocyte cells (HaCat) demonstrated notable biocompatibility with prepared nanofibers. Furthermore, compare to other groups, Sol-SPI-Mp caused fastest re-epithelialization healing a rat model. findings this study present novel nanofiber-based dressing that accelerates severe skin wounds risk infection.

Language: Английский

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Three-dimensional printed polyelectrolyte construct containing mupirocin-loaded quaternized chitosan nanoparticles for skin repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 136214 - 136214

Published: Oct. 1, 2024

Language: Английский

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Wound Dressing Based on Silver Nanoparticle Embedded Wool Keratin Electrospun Nanofibers Deposited on Cotton Fabric: Preparation, Characterization, Antimicrobial Activity, and Cytocompatibility

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2164 - 2174

Published: March 17, 2024

Wool keratin (WK) protein is attractive for wound dressing and biomedical applications due to its excellent biodegradability, cytocompatibility, wound-healing properties. In this work, WK-based dressings were prepared by depositing WK/poly(vinyl alcohol) (PVA) silver nanoparticle (Ag NP)-embedded WK/PVA composite nanofibrous membranes on cotton fabrics electrospinning. Ag NPs biosynthesized reduction stabilization with sodium alginate. The formed characterized ultraviolet–visible Fourier transform infrared (FTIR) spectroscopy, their size was determined transmission electron microscopy image analysis. spherical had an average diameter of 9.95 nm. produced NP-embedded nanofiber-deposited fabric surface FTIR dynamic contact angle measurements, the nanofiber morphologies scanning microscopy. nanofibers 0.1% solution 146.7 antibacterial activity coated electrospun evaluated against two most common wound-causing pathogens, Staphylococcus aureus Pseudomonas aeruginosa. showed very good both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results cytocompatibility L-929 mouse fibroblast cells. However, increase in NP content 0.2% negatively affected cell viability high release rate ions. achieved show that developed has potential healing applications.

Language: Английский

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In-vitro and in-vivo studies of Tridax procumbens leaf extract incorporated bilayer polycaprolactone/polyvinyl alcohol-chitosan electrospun nanofiber for wound dressing application

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 139920 - 139920

Published: Jan. 22, 2025

Language: Английский

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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 30, 2025

Language: Английский

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A review on pectin-based nanostructures for drug and gene delivery systems

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140932 - 140932

Published: Feb. 11, 2025

Language: Английский

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