Polymers,
Journal Year:
2024,
Volume and Issue:
16(24), P. 3516 - 3516
Published: Dec. 18, 2024
Powder-based
hemostatic
materials
have
offered
unprecedented
opportunities
for
the
effective
sealing
and
repair
of
irregularly
shaped
wounds
high-pressure,
noncompressible
arterial
bleeding
caused
by
surgeries,
traffic
accidents,
wartime
injuries.
However,
inadequate
adhesion
to
poor
hemostasis
in
biological
tissues
remains
challenging.
Herein,
we
report
a
self-gelling
powder
based
on
polyacrylic
acid/polyethyleneimine/polyethylene
glycol
(named
PPG)
rapid
antibacterial
ability.
When
deposited
wounds,
PPG
can
absorb
interfacial
liquid
rapidly
swell
into
physically
cross-linked
hydrogel
situ
within
2
s
form
pressure-resistant
physical
barrier.
Furthermore,
vivo
vitro
results
indicate
that,
as
an
sealant,
possesses
ease
use,
excellent
hemocompatibility,
strong
abilities,
superior
blood
clotting
abilities.
The
capability
is
demonstrated
variety
injury
models
rats
rabbits.
All
these
factors
show
with
its
wound
treatment
profound
biomaterial
surgical
applications.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 162 - 162
Published: Jan. 10, 2025
The
problem
of
antibiotic
abuse
and
drug
resistance
is
becoming
increasingly
serious.
In
recent
years,
polydopamine
(PDA)
nanoparticles
have
been
recognized
as
a
potential
antimicrobial
material
for
photothermal
therapy
(PTT)
due
to
their
excellent
conversion
efficiency
unique
ability.
PDA
capable
rapidly
converting
light
energy
into
heat
under
near-infrared
(NIR)
irradiation
kill
bacteria
efficiently.
order
solve
the
PDA's
tendency
aggregate
precipitate,
this
study
improved
its
stability
by
grafting
hyaluronic
acid
(HA)
onto
surface
PDA.
Using
dopamine
raw
materials,
was
grafted
via
self-polymerization
Michael
addition
reactions
alkaline
conditions
obtain
PDA-HA-modified
nanoparticles.
We
confirmed
successful
scanning
electron
microscopy
(SEM),
Fourier
infrared
spectroscopy
(FTIR),
nuclear
magnetic
hydrogen
(¹H
NMR),
ultraviolet-visible
(UV-vis),
Raman
(Raman),
dynamic
scattering
(DLS)
methods.
Scanning
(SEM)
used
observe
morphology
nanostructure
providing
information
on
size
distribution
materials.
Near-infrared
performance
experiments
showed
that
temperature
PDA-HA
solution
increased
irradiation,
demonstrating
an
performance.
Antimicrobial
properties
were
assessed
colony
counting
method,
typical
Gram-positive
S.
aureus
Gram-negative
E.
coli
selected
model
strains.
experimental
groups
tested
dark
irradiation.
PDA/HA
significant
NIR
resulting
in
rapid
increase
surrounding
level
sufficient
bacteria.
Under
exhibited
100%
efficacy
against
both
coli,
while
limited
conditions.
This
indicates
antibacterial
activity
highly
dependent
activation.
