Polymers,
Journal Year:
2024,
Volume and Issue:
16(24), P. 3516 - 3516
Published: Dec. 18, 2024
Powder-based
hemostatic
materials
have
offered
unprecedented
opportunities
for
the
effective
sealing
and
repair
of
irregularly
shaped
wounds
high-pressure,
noncompressible
arterial
bleeding
caused
by
surgeries,
traffic
accidents,
wartime
injuries.
However,
inadequate
adhesion
to
poor
hemostasis
in
biological
tissues
remains
challenging.
Herein,
we
report
a
self-gelling
powder
based
on
polyacrylic
acid/polyethyleneimine/polyethylene
glycol
(named
PPG)
rapid
antibacterial
ability.
When
deposited
wounds,
PPG
can
absorb
interfacial
liquid
rapidly
swell
into
physically
cross-linked
hydrogel
situ
within
2
s
form
pressure-resistant
physical
barrier.
Furthermore,
vivo
vitro
results
indicate
that,
as
an
sealant,
possesses
ease
use,
excellent
hemocompatibility,
strong
abilities,
superior
blood
clotting
abilities.
The
capability
is
demonstrated
variety
injury
models
rats
rabbits.
All
these
factors
show
with
its
wound
treatment
profound
biomaterial
surgical
applications.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(24), P. 3516 - 3516
Published: Dec. 18, 2024
Powder-based
hemostatic
materials
have
offered
unprecedented
opportunities
for
the
effective
sealing
and
repair
of
irregularly
shaped
wounds
high-pressure,
noncompressible
arterial
bleeding
caused
by
surgeries,
traffic
accidents,
wartime
injuries.
However,
inadequate
adhesion
to
poor
hemostasis
in
biological
tissues
remains
challenging.
Herein,
we
report
a
self-gelling
powder
based
on
polyacrylic
acid/polyethyleneimine/polyethylene
glycol
(named
PPG)
rapid
antibacterial
ability.
When
deposited
wounds,
PPG
can
absorb
interfacial
liquid
rapidly
swell
into
physically
cross-linked
hydrogel
situ
within
2
s
form
pressure-resistant
physical
barrier.
Furthermore,
vivo
vitro
results
indicate
that,
as
an
sealant,
possesses
ease
use,
excellent
hemocompatibility,
strong
abilities,
superior
blood
clotting
abilities.
The
capability
is
demonstrated
variety
injury
models
rats
rabbits.
All
these
factors
show
with
its
wound
treatment
profound
biomaterial
surgical
applications.
