Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation DOI
Sankha Bhattacharya, Shashikant B. Bagade, Preeti C. Sangave

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Language: Английский

Stimulus-Responsive Hydrogels for Targeted Cancer Therapy DOI Creative Commons
Raghu Solanki, Dhiraj Bhatia

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 440 - 440

Published: July 1, 2024

Cancer is a highly heterogeneous disease and remains global health challenge affecting millions of human lives worldwide. Despite advancements in conventional treatments like surgery, chemotherapy, immunotherapy, the rise multidrug resistance, tumor recurrence, their severe side effects complex nature microenvironment (TME) necessitates innovative therapeutic approaches. Recently, stimulus-responsive nanomedicines designed to target TME characteristics (e.g., pH alterations, redox conditions, enzyme secretion) have gained attention for potential enhance anticancer efficacy while minimizing adverse chemotherapeutics/bioactive compounds. Among various nanocarriers, hydrogels are intriguing due high-water content, adjustable mechanical characteristics, responsiveness external internal stimuli, making them promising candidates cancer therapy. These properties make an ideal nanocarrier controlled drug release within TME. This review comprehensively surveys latest area therapy, exploring stimuli-responsive mechanisms, including biological pH, redox), chemical enzymes, glucose), physical temperature, light), as well dual- or multi-stimuli responsiveness. Furthermore, this addresses current developments challenges treatment. Our aim provide readers with comprehensive understanding treatment, offering novel perspectives on development therapy other medical applications.

Language: Английский

Citations

11
Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels DOI Creative Commons
Bing Ma, Qing Li, Jingjing Zhang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(1), P. 40 - 40

Published: Jan. 11, 2024

The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release Doxorubicin HCl (DOX.HCl). BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using ion crosslinking method. method resulted in low polydispersity index, small particle size, positive zeta potential values, indicating good stability nanogels. Compared to hydroxypropyl trimethyl chloride chitosan-Doxorubicin HCl-sodium (HACC-D-TPP) nanogel, salt-Doxorubicin (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency loading capacity (BIMIXHAC-D-TPP 93.17 ± 0.27% 31.17 0.09%), release profiles accelerated vitro. chitosan-sodium (HACC-TPP), salt-sodium (BIMIXHAC-TPP) demonstrated favorable antioxidant capability. assay cell viability, measured by MTT assay, revealed that led significant reduction viability two cancer cells: human lung adenocarcinoma epithelial line (A549) breast (MCF-7). Furthermore, BIMIXHAC-D-TPP 2.96 times less toxic than DOX.HCl mouse fibroblast (L929). It indicated BIMIXHAC-based enhanced antitumor activities acidic-responsive could serve as nanocarrier.

Language: Английский

Citations

4
Intelligent responsive nanogels: New Horizons in cancer therapy DOI
Mazlina Musa, Xinxin Sun, Jianbin Shi

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125050 - 125050

Published: Dec. 5, 2024

Language: Английский

Citations

3
pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery DOI
Akshant Kumawat, Mrinmoy Karmakar, Chinmay Ghoroi

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 18964 - 18978

Published: Aug. 2, 2024

In the realm of colon-based drug delivery, developing a pH-responsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in molar ratio 1:4 via free radical polymerization. The spherical NG size 190 ± 15 nm confirmed by field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals hydrodynamic diameter zeta potential 271 23 −6.9 2.3 mV, respectively. FTIR, XPS, NMR analyses confirm presence multiple functionalities on NG. Significant improvement swelling (10 times) at colonic pH (pH 7.4) contrast to gastric 1.2) ensures behavior along with five times higher ROS compared control. As model drug, doxorubicin (DOX) employed investigate release properties cellular uptake. exhibited loading capacity efficiency 26 1.2% 90 1.3%, respectively, three DOX 7.4 than 1.2. Rheology data reveal superior structural integrity loaded (DNG) biocompatibility through MTT, hemolysis assay, cell uptake assays HCT-116 colon cancer cells. studies have indicated NG-mediated microenvironment subsequent passive diffusion into These findings underscore capability as vehicle for oral delivery colon.

Language: Английский

Citations

2
Precise Photothermal Treatment of Bacterial Infection Mediated by Charge-Switchable Nanoplatform with Acylsulfonamide Betaine Surface DOI

Wenyuan Sun,

Shumin Hu,

Binzhong Lu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114362 - 114362

Published: Nov. 5, 2024

Language: Английский

Citations

1
Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation DOI
Sankha Bhattacharya, Shashikant B. Bagade, Preeti C. Sangave

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Language: Английский

Citations

1