Polymers,
Journal Year:
2025,
Volume and Issue:
17(10), P. 1411 - 1411
Published: May 20, 2025
Nanostructured
drug-delivery
systems
with
enhanced
therapeutic
potential
have
gained
attention
in
biomedical
applications.
Here,
flufenamic
acid
(FFA)-loaded
chitosan/poly(vinyl
alcohol)
(CHS/PVA;
CSPA)-based
electrospun
nanofibers
were
fabricated
and
characterized
for
antibacterial,
anticancer,
antioxidant
activities.
The
FFA-loaded
CSPA
(FCSPA)
by
scanning
electron
microscopy,
Fourier-transform
infrared
spectroscopy,
X-ray
diffraction
(XRD),
differential
calorimetry
to
evaluate
their
formation
process,
functional
group
interactions,
crystallinity.
Notably,
the
average
diameter
of
FCSPA
decreased
increasing
contents
(CSPA-1
CSPA-3),
indicating
that
FFA
addition
CSPA-3
significantly
its
diameter.
Additionally,
XRD
confirmed
dispersion
within
amorphous
matrix,
enhancing
drug
stability.
exhibited
a
high
swelling
ratio
(significantly
higher
than
samples).
Biodegradation
studies
revealed
accelerated
weight
loss
after
72
h,
improved
degradation
compared
those
other
formulations.
Furthermore,
it
drug-encapsulation
efficiency,
ensuring
sustained
release.
excellent
antibacterial
activity,
inhibiting
Staphylococcus
aureus
Escherichia
coli.
Regarding
anticancer
HCT-116
cell
viability,
highlighting
controlled
potential.
Moreover,
demonstrated
superior
antioxidation,
scavenging
DPPH
free
radicals.
These
findings
highlight
as
multifunctional
platforms
wound-healing,
drug-delivery,
tissue-engineering
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3136 - 3136
Published: July 1, 2024
Dihydromyricetin
(DMY)
has
been
encapsulated
in
delivery
systems
to
address
the
solubility
limitations
of
DMY
water
and
improve
its
bioavailability.
Air-assisted
electrospinning
used
as
a
novel
technology
load
DMY.
To
evaluate
impact
adding
dextran/zein
nanofibers
understand
effects
Maillard
reaction
(MR)
on
physical
functional
properties
DMY-loaded
nanofibers,
dextran/zein/xylose
with
0%,
1%,
2%,
3%,
4%
were
fabricated,
followed
by
MR
crosslinking.
Scanning
electron
microscopy
(SEM)
observations
indicated
that
addition
did
not
affect
morphology
nanofibers.
X-ray
diffraction
(XRD)
results
amorphous
dispersion
within
decreased
crystalline
structure
following
MR,
which
might
their
molecular
flexibility.
The
nanofibrous
film
formed
after
exhibited
both
increased
tensile
strength
elastic
modulus
due
hydrogen
bonding
elongation
at
break
attributed
amorphization
also
found
exhibit
improved
heat
stability
MR.
antioxidant
activity
dose-dependent
effect
radical
scavenging
reducing
power.
maintenance
suggested
during
treatment.
Overall,
various
contents
tunable
effective
activities,
indicating
offer
successful
system,
can
be
further
applied
an
active
package.
