Preparation, Characterization, and Antibacterial Activity of Amino Acids Grafted‐Chitosan/Glycerophosphate Hydrogel DOI

Su Ping Dai,

Hui Yun Zhou,

Li Jun Ren

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(45)

Published: Nov. 28, 2024

Abstract In this paper, L‐lysine (Lys), L‐glutamic acid (Glu), and L‐glutamine (Gln) ‐grafted chitosan (CS) polymers (AA‐g‐CS) are prepared by a one‐pot method, employing EDC/NHS as coupling agent. Then AA‐g‐CS glycerol phosphate hydrogels (AA‐g‐CS/GP hydrogel) physical cross‐linking method. The AA‐g‐CS/GP hydrogel has dense 3D network structure, which facilitates the loading of drugs. pore size wall affected amino types (Lys, Glu Gln). Berberine hydrochloride (BBH) is encapsulated in three‐dimensional structure hydrogel. Escherichia coli (Gram‐negative bacteria, E. ) Staphylococcus aureus (Gram‐positive S. selected model antibacterial properties BBH@AA‐g‐CS/GP investigated AGAR drilling method turbidimetric results show that better inhibition effect on than . can achieve long‐term within 24 h. Therefore, an excellent carrier for BBH expected to be applied extensively wound healing, tissue regeneration, cell culture.

Language: Английский

The Role of Polysaccharide-based Biodegradable Soft Polymers in the Healthcare Sector DOI Creative Commons
Zia Ullah Arif

Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.

Language: Английский

Citations

19
Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review DOI
Praveen Ramakrishnan,

Ramakrishnan Ramprasath,

Abdulkadhar Mohamed Jalaludeen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139663 - 139663

Published: Jan. 8, 2025

Language: Английский

Citations

4
Lauric acid-loaded biomimetic, biocompatible, and antioxidant jelly fig (Ficus awkeotsang Makino) pectin hydrogel accelerates wound healing in diabetic rats DOI
Thangavel Ponrasu,

Iniyan Saravanakumar,

Sushil Kumar

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139484 - 139484

Published: Jan. 1, 2025

Language: Английский

Citations

0
Increasing nitrogen source by chitosan coupled with nZVI-jelly fig peel biochar to improve O2 reduction to H2O2 and its electrochemical performance DOI
Chi‐Wen Lin,

Ying-Cih Song,

Shu-Hui Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140788 - 140788

Published: Feb. 1, 2025

Language: Английский

Citations

0
Preparation of TEMPO-partially oxidized sodium alginate/SF scaffolds with degradation compatibility for skin defect repair DOI
Xinxin Zhao, Wenyuan Wang, Bo Cheng

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123437 - 123437

Published: Feb. 25, 2025

Language: Английский

Citations

0
Effects of Different Drying Methods on Structural Characterization, Rheological Properties, Antioxidant and Hypolipidemic Activities of Polysaccharides from Fig (Ficus carica L.) DOI Creative Commons
Gang Zhao, Jingya Wu,

Mingguan Yang

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4215 - 4215

Published: April 11, 2025

In this study, figs were dried by hot air drying (HD), vacuum freeze-drying (FD), (VD) and far-infrared (FID). Four fig polysaccharides (FPs) extracted from different figs, the corresponding names FPH, FPF, FPV FPFI. The effects of methods on structural properties, rheological properties biological activities FPs compared. result shows that extraction rate after FD (2.49%) treatment was 58.60%, 50% 28.35% higher than HD (1.57%), VD (1.66%) FID (1.94%), respectively. Drying in varying molar ratios monosaccharides. FPFI has more stable gel properties. HD, caused damage to surface structure polysaccharides. FPF exhibited highest uronic acid content (25.56%), along with relatively low apparent viscosity molecular weight (1.45 × 105 Da), which contributed its superior antioxidant lipid-lowering activities. Therefore, is a method obtain polysaccharide high hypolipidemic activity. results provided scientific basis for process reference development potential products polysaccharide.

Language: Английский

Citations

0
Review of the recent advances in polysaccharides from Ficus carica: Extraction, purification, structural characteristics, bioactivities and potential applications DOI
Ting Zhang, Mengjie Chen, Dan Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136430 - 136430

Published: Oct. 9, 2024

Language: Английский

Citations

2
l-Arginine-Loaded Oxidized Isabgol/Chitosan-Based Biomimetic Composite Scaffold Accelerates Collagen Synthesis, Vascularization, and Re-epithelialization during Wound Healing in Diabetic Rats DOI

Iniyan Saravanakumar,

Thangavel Ponrasu, Vignesh Muthuvijayan

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 6162 - 6174

Published: Aug. 17, 2024

Impaired wound healing in diabetic wounds is common due to infection, inflammation, less collagen synthesis, and vascularization. Diabetic patients still a challenge needs an ideal dressing treat manage wounds. Herein, efficacious biomaterial was fabricated by cross-linking oxidized isabgol (Oisab) chitosan (Cs)

Language: Английский

Citations

0
Fabrication of thymol‐loaded isabgol/Konjac glucomannan‐based microporous scaffolds with enriched antioxidant and antibacterial properties for skin tissue engineering applications DOI

Shruthi Sakthivel,

Thangavel Ponrasu,

Iniyan Saravanakumar

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract An antioxidant, antibacterial, and biocompatible biomaterial is essential to repair skin wounds effectively. Here, we have employed two natural biopolymers, isabgol (ISAB) konjac glucomannan (KGM), prepare microporous scaffolds by freezing lyophilization. The are loaded with thymol (THY) impart potent antioxidant antibacterial activities. physicochemical properties of the ISAB+KGM+THY scaffold, like porosity (41.8±2.4 %), swelling, biodegradation, were optimal for tissue regeneration application. Compared control, promote attachment, migration, proliferation L929 fibroblasts. activity scaffold was significantly improved after loading THY. This would protect tissues from oxidative damage. higher than that which help prevent bacterial infection. vascularization ability ISAB+KGM not altered incorporating THY in scaffold. Therefore, a strong nature could be useful various biomedical applications.

Language: Английский

Citations

0
Preparation, Characterization, and Antibacterial Activity of Amino Acids Grafted‐Chitosan/Glycerophosphate Hydrogel DOI

Su Ping Dai,

Hui Yun Zhou,

Li Jun Ren

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(45)

Published: Nov. 28, 2024

Abstract In this paper, L‐lysine (Lys), L‐glutamic acid (Glu), and L‐glutamine (Gln) ‐grafted chitosan (CS) polymers (AA‐g‐CS) are prepared by a one‐pot method, employing EDC/NHS as coupling agent. Then AA‐g‐CS glycerol phosphate hydrogels (AA‐g‐CS/GP hydrogel) physical cross‐linking method. The AA‐g‐CS/GP hydrogel has dense 3D network structure, which facilitates the loading of drugs. pore size wall affected amino types (Lys, Glu Gln). Berberine hydrochloride (BBH) is encapsulated in three‐dimensional structure hydrogel. Escherichia coli (Gram‐negative bacteria, E. ) Staphylococcus aureus (Gram‐positive S. selected model antibacterial properties BBH@AA‐g‐CS/GP investigated AGAR drilling method turbidimetric results show that better inhibition effect on than . can achieve long‐term within 24 h. Therefore, an excellent carrier for BBH expected to be applied extensively wound healing, tissue regeneration, cell culture.

Language: Английский

Citations

0