Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Nanocomposite smart gels (Nc- x ) with self-healing and shape memory properties were designed in different types size nano particles temperature or light stimuli.
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101496 - 101496
Published: Jan. 25, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Diabetic wounds pose significant challenges in healthcare due to their slow healing rates and susceptibility infections, leading severe complications. In this study, we developed a carbon nanotube-based conductive protein-cellulose hydrogel designed enhance wound through photothermal therapy. The hydrogel's unique properties, including high electrical conductivity biocompatibility, were assessed vitro for cell viability, hemolysis, histological evaluations. vivo studies on diabetic rats revealed that the significantly improved healing, with faster closure rates. These results supported by noticeable reductions inflammatory markers enhanced blood vessel formation, as observed immunohistochemical analysis. Additionally, photoacoustic imaging offered real-time data flow tissue oxygen levels, showing positive trends process. Overall, these findings point potential of hydrogel, especially when paired therapy, serve an effective treatment wounds, offering promising possibilities care strategies.
Language: Английский
Citations
0
Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: March 19, 2025
The synergistic approach of liposome integrated with gel matrix could reshape the current frameworks drug delivery technology. liposome-based approaches are limited by inadequate stability and rapid leakage molecules. Undesired immediate release from increases local concentration causes toxicity. So, stabilization liposomes within a can be an effective option to provide ingenious solution conventional limitation on short half-life, instability, toxicity, uncontrolled poor retention molecules target site. capability incorporate antibacterial as well anti-oxidant drugs, antimicrobial peptides, ligands, growth hormones, antigens, imaging agents had contributed establishment multifunctional liposomal system has significant advantage in regenerative medicine area. This review will focus gels context infectious wound healing, skin rejuvenation, musculoskeletal repair trauma management, spinal cord injury treatment, tumor specific chemotherapy immunotherapy vaccination. versatility executing multiple functions valuable for advancing therapeutic outcomes medicine.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
In this study, a near-infrared (NIR)-responsive hydrogel based on ethylenediamine (EDA)-functionalized Gellan Gum was developed through simple preparation method. This incorporates in situ synthesized polydopamine (pDA) and loaded with first- second-generation antimicrobial bis-MPA polyester dendrimers (TMP-G1-[Cys]6 MP-G2-[Cys]12), bearing cysteamine hydrochloride as peripheral functional groups. The intrinsic ability of pDA to scavenge reactive oxygen species (ROS) convert NIR light at 810 nm into heat imparted radical scavenging activity photothermal properties the systems. It has been demonstrated that, due noncovalent interactions both GG-EDA pDA, are retained differently within sample depending their molecular weight number terminal positive charges. difference retention influences against Pseudomonas aeruginosa Staphylococcus aureus. particular, it shown that NIR-induced effect plays crucial role triggering most dendrimer, which possesses highest high physiological fluid absorption capacity makes these materials ideal for wound exudate management. addition, resistance hydrolytic degradation can be exploited reduce frequency dressing changes, potentially improving patient comfort. dendrimer-loaded samples low cytotoxicity toward human fetal dermal mesenchymal stromal cells (FD-MSCs) epidermal keratinocytes (HaCaT). These findings suggest GG-EDA@pDA+TMP-G1-[Cys]6 or TMP-G2-[Cys]12 could promising candidates treatment infected skin wounds.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412
Published: April 25, 2025
Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.
Language: Английский
Citations
0
AIP Advances, Journal Year: 2024, Volume and Issue: 14(9)
Published: Sept. 1, 2024
Wound dressings play a critical role in promoting healing by protecting wounds from external contaminants and providing an optimal environment for tissue regeneration. Traditional dressings, such as gauze cotton, offer basic physical barriers but lack the ability to maintain moist wound environment, which is essential healing. Modern particularly those incorporating electrospun nanofibers, have emerged advanced solutions that can sustain moisture, absorb exudate, support cell growth migration. This Review covers recent advances electrospinning technologies design of composite materials integrate natural synthetic polymers, bioactive agents, nanomaterials enhance In addition, it highlights key studies demonstrating efficacy these composites various models. The primary objective this inspire guide future research endeavors, address existing limitations, shed light on promising prospects field
Language: Английский
Citations
2
Journal of Research Updates in Polymer Science, Journal Year: 2024, Volume and Issue: 13, P. 130 - 146
Published: Sept. 27, 2024
Hydrogel-based bioinks have emerged as a critical component in the field of three-dimensional (3D) bioprinting, with numerous polymers being explored and utilized for this purpose. The high volume patent applications reflects competitive dynamic research environment, where various entities are actively developing new formulations hydrogel-based bioinks. As continues to evolve, tracking these trends is essential understanding future direction technology identifying key innovations players industry. This study reveals substantial growth landscape 3D 173 documents published between 2013 2024. marked increase filings, particularly from 2018 onwards, underscores growing recognition technologys potential diverse applications, including tissue engineering regenerative medicine. Although outpaced granted patents, steady rise patents indicates fields maturation transition concept legally protected technologies. leading applicants domain include both industry leaders academic institutions. Companies such Organovo INC Cellink AB driving innovation through extensive activity, while institutions foundations also make significant contributions, highlighting robust ecosystem industrial propel forward. global distribution intellectual property filings broad, activity United States, Europe, Asia. diversity patenting jurisdictions interest advancing bioprinting technologies, healthcare applications. Patent classifications illustrate convergence materials science, biotechnology, advanced manufacturing. These highlight bioinks, ranging regeneration stem cell therapy development medical devices multifunctional bioactive based on polymers.
Language: Английский
Citations
2
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102209 - 102209
Published: July 24, 2024
Language: Английский
Citations
1
European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113457 - 113457
Published: Sept. 1, 2024
Language: Английский
Citations
1
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122894 - 122894
Published: Oct. 21, 2024
Language: Английский
Citations
1