Improved epirubicin delivery selectivity to bladder cancer achieved by functionalized hydroxyethyl starch-based prodrug DOI
Xiaohan Pan, Peng Wang, Jiahui Gu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 293, P. 139275 - 139275

Published: Dec. 28, 2024

Language: Английский

Phenylboronic Acid‐Functionalized Hyaluronic Acid as Polysaccharide Carriers for Diol‐Containing Drugs Delivery DOI
Yu‐Hui Zhang, Ye Tian, Bo Wang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract Packaging hydrophobic drugs into polysaccharide carriers can improve their aqueous solubility, biocompatibility, tumor‐specific accumulation, and therapeutic effect. In this work, phenylboronic acid (PBA) was anchored onto the chain of biocompatible hyaluronic (HA) by an amide condensation reaction, which could be used to fabricate stimuli‐responsive targeted drug delivery systems. A series pH‐responsive conjugated nanoparticles composed a core hydrophilic shell were prepared boronate‐crosslink PBA with diol‐containing anticancer such as capecitabine (CAPE) aloin (Al). Satisfactory release behavior at acidic pH, lower cytotoxicity, higher effect realized using carrier. It is believed that strategy has great potential for modification anticancer‐associated applications.

Language: Английский

Citations

1
Light-Emitting Coordination Polymers: Stimuli-Responsive Gels, PMMA-Based Composite Films, and UV-Shielding DOI
Bilash Chandra Roy,

Vishwakarma Ravikumar Ramlal,

Dipmalya Basak

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(48), P. 23044 - 23056

Published: Nov. 15, 2024

Lanthanide-based light-emitting coordination polymers (CPs) and CP gels (CPGs) have significance for applications in optical systems, image processing/multiplexing, sensors. In this study, we report two new luminescent CPs (EuL-CP (

Language: Английский

Citations

1
Advancing Ovarian Cancer Therapeutics: The Role of Targeted Drug Delivery Systems DOI Creative Commons

Qianhan Lin,

Jiajia Li,

Zulimire Abudousalamu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9351 - 9370

Published: Sept. 1, 2024

Ovarian cancer (OC) is the most lethal reproductive system and a leading cause of cancer-related death.The high mortality rate poor prognosis OC are primarily due to its tendency for extensive abdominal metastasis, late diagnosis in advanced stages, an immunosuppressive tumor microenvironment, significant adverse reactions first-line chemotherapy, development chemoresistance.Current adjuvant chemotherapies face challenges such as targeting, low efficacy, side effects.Targeted drug delivery systems (TDDSs) designed deliver drugs precisely site enhance efficacy minimize effects.This review highlights recent advancements use TDDSs therapies, including conjugate systems, nanoparticle hydrogel systems.The focus on employing TDDS conduct direct, effective, safer interventions through methods targeted recognition controlled release, either independently or combination.This also discusses prospects further TDDSs.Undoubtedly, shows promise battle against OCs.

Language: Английский

Citations

0
Improved epirubicin delivery selectivity to bladder cancer achieved by functionalized hydroxyethyl starch-based prodrug DOI
Xiaohan Pan, Peng Wang, Jiahui Gu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 293, P. 139275 - 139275

Published: Dec. 28, 2024

Language: Английский

Citations

0