Catalysts,
Journal Year:
2024,
Volume and Issue:
14(6), P. 371 - 371
Published: June 10, 2024
Chitin
and
chitosan,
abundant
biopolymers
derived
from
the
shells
of
crustaceans
cell
walls
fungi,
have
garnered
considerable
attention
in
pharmaceutical
circles
due
to
their
biocompatibility,
biodegradability,
versatile
properties.
Deep
eutectic
solvents
(DESs),
emerging
green
composed
mixtures
hydrogen
bond
acceptors
donors,
offer
promising
avenues
for
enhancing
solubility
functionality
chitin
chitosan
formulations.
This
review
delves
into
potential
utilizing
DESs
as
highlighting
efficiency
dissolving
these
polymers,
which
facilitates
production
novel
drug
delivery
systems,
wound
dressings,
tissue
engineering
scaffolds,
antimicrobial
agents.
The
distinctive
physicochemical
properties
DESs,
including
low
toxicity,
volatility,
adaptable
solvation
power,
enable
customization
chitosan-based
materials
meet
specific
requirements.
Moreover,
environmentally
friendly
nature
aligns
with
growing
demand
sustainable
eco-friendly
processes
manufacturing.
revision
underscores
recent
advances
illustrating
role
evolving
applications
laying
groundwork
development
innovative
systems
biomedical
enhanced
efficacy
safety
profiles.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1315 - 1315
Published: May 8, 2024
A
hybrid
synthetic-natural,
thermoresponsive
graft
copolymer
composed
of
poly(N-isopropyl
acrylamide)
(PNIPAM)
side
chains,
prepared
via
RAFT
polymerization,
and
a
chitosan
(Chit)
polysaccharide
backbone,
was
synthesized
radical
addition-fragmentation
reactions
using
the
“grafting
to”
technique,
in
aqueous
solution.
ATR-FTIR,
TGA,
polyelectrolyte
titrations
1H
NMR
spectroscopy
were
employed
order
to
validate
Chit-g-PNIPAM
chemical
structure.
Additionally,
spectra
back
conductometric
titration
utilized
quantify
content
grafted
PNIPAM
chains.
The
resulting
contains
dual
functionality,
namely
both
pH
responsive
free
amino
groups,
with
electrostatic
complexation/coordination
properties,
Particle
size
measurements
dynamic
light
scattering
(DLS)
used
study
behavior
copolymer.
Thermal
properties
examined
by
TGA
showed
that,
grafting
modification
PNIPAM,
Chit
structure
became
more
thermally
stable.
lower
critical
solution
temperature
(LCST)
determined
DLS
at
25–45
°C.
Furthermore,
electrophoretic
demonstrated
that
is
suitable
binding
DNA
molecules
forms
nanosized
polyplexes
different
phosphate
groups
ratios,
potential
application
as
gene
delivery
systems.
Catalysts,
Journal Year:
2024,
Volume and Issue:
14(6), P. 371 - 371
Published: June 10, 2024
Chitin
and
chitosan,
abundant
biopolymers
derived
from
the
shells
of
crustaceans
cell
walls
fungi,
have
garnered
considerable
attention
in
pharmaceutical
circles
due
to
their
biocompatibility,
biodegradability,
versatile
properties.
Deep
eutectic
solvents
(DESs),
emerging
green
composed
mixtures
hydrogen
bond
acceptors
donors,
offer
promising
avenues
for
enhancing
solubility
functionality
chitin
chitosan
formulations.
This
review
delves
into
potential
utilizing
DESs
as
highlighting
efficiency
dissolving
these
polymers,
which
facilitates
production
novel
drug
delivery
systems,
wound
dressings,
tissue
engineering
scaffolds,
antimicrobial
agents.
The
distinctive
physicochemical
properties
DESs,
including
low
toxicity,
volatility,
adaptable
solvation
power,
enable
customization
chitosan-based
materials
meet
specific
requirements.
Moreover,
environmentally
friendly
nature
aligns
with
growing
demand
sustainable
eco-friendly
processes
manufacturing.
revision
underscores
recent
advances
illustrating
role
evolving
applications
laying
groundwork
development
innovative
systems
biomedical
enhanced
efficacy
safety
profiles.
