Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Recent advances and current status of gene therapy for epilepsy

World Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 20(11), P. 1115 - 1137

Published: Oct. 12, 2024

Language: Английский

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Identification of Novel miRNA Biomarkers for Epilepsy: A qRT-PCR-Based Profiling Study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Epilepsy is a widespread neurological disorder affecting over 70 million individuals globally, with approximately 4.9 new cases diagnosed annually. Despite extensive research, the underlying mechanisms of epilepsy remain incompletely elucidated. MicroRNAs (miRNAs) are being increasingly utilized as crucial biomarkers in various disorders, and their targeting proteins involved disease pathogenesis represents promising therapeutic strategy. This study aimed to identify novel candidate miRNAs associated evaluate diagnostic potential. The expression profiles 84 were analyzed plasma samples from 20 patients 25 controls using qRT-PCR on BioMarkTM 96.96 Dynamic Array (Fluidigm Corporation) system. In group, total 44 exhibited decreased compared control which 24 statistically significant. Notably, 18 demonstrated highly significant reduction levels (p< 0.0001). These include hsa-let-7e-5p, hsa-miR-105-5p, hsa-miR-106b-5p, hsa-miR-107, hsa-miR-125b-5p, hsa-miR-128, hsa-miR-135b-5p, hsa-miR-138-5p, hsa-miR-152, hsa-miR-15a-5p, hsa-miR-193b-3p, hsa-miR-203a, hsa-miR-339-5p, hsa-miR-381-3p, hsa-miR-409-3p, hsa-miR-511, hsa-miR-539-5p, hsa-miR-7-5p. 40 increased among 28 23 increase (p < hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR-132-3p, hsa-miR-146a-5p, hsa-miR-146b-5p, hsa-miR-181a-5p, hsa-miR-212-3p, hsa-miR-27a-3p, hsa-miR-28-5p, hsa-miR-302b-5p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-34a-5p, hsa-miR-455-5p, hsa-miR-485-5p, hsa-miR-487a, hsa-miR-499a-5p, hsa-miR-509-3p, hsa-miR-512-3p, hsa-miR-518b, hsa-miR-652-3p, hsa-miR-9-3p, hsa-miR-95. findings suggest that hold potential innovative, non-invasive for early detection diagnosis epilepsy, offering avenue advancing clinical practices.

Language: Английский

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Significance of miR-1290 in glioblastoma patients with epilepsy

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

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Emerging Roles of ncRNAs in Type 2 Diabetes Mellitus: From Mechanisms to Drug Discovery

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1364 - 1364

Published: Oct. 27, 2024

Type 2 diabetes mellitus (T2DM), a high-incidence chronic metabolic disorder, has emerged as global health issue, where most patients need lifelong medication. Gaining insights into molecular mechanisms involved in T2DM development is expected to provide novel strategies for clinical prevention and treatment. Growing evidence validates that non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs) function crucial regulators multiple biological processes of T2DM, inspiring various potential targets drug candidates. In this review, we summarize the current understanding ncRNA roles discuss use ncRNAs active molecules discovery.

Language: Английский

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miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells

Genes & Genomics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

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Platelet-rich plasma protects hippocampal neurons and memory functions in a rat model of vascular dementia

Anatomy & Cell Biology, Journal Year: 2024, Volume and Issue: 57(4), P. 559 - 569

Published: Aug. 21, 2024

Platelet-rich plasma (PRP) is a promising biomaterial rich in bioactive growth factors, offering potential as therapeutic agent for various diseases. However, its effectiveness central nervous system disorders like vascular dementia (VaD) remains underexplored. This study investigated the of PRP to mitigate VaD progression

Language: Английский

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