Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 251 - 285

Published: Nov. 15, 2024

The encapsulation of active pharmaceutical ingredients (APIs) in microbeads is an essential step drug delivery; however, it also inherently associated with the need to control particle size and release profiles. Nevertheless, most conventional methods microencapsulation fail provide consistent results. A new method called vibration-assisted microbead coating a novel unified technique utilizing mechanical vibrations enable controlled, uniform on APIs. This chapter discusses technology performed by authors through formation physical activity focuses achieving final coated surface API, shape, size, loading vibration parameters. Additionally, this biocompatibility stability surface. means has high potential for delivery. reduces traditional challenges encapsulation, if not eliminates them, more reliable. Based abovementioned findings, propose following main areas their further work: optimisation parameters various APIs, research into long-term loading–release profile, possible use targeted

Language: Английский

Review: Biomacromolecules‐based encapsulation technologies for the protection of oxygen‐sensitive next‐generation probiotics

Food biomacromolecules., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract In the recent years, various strains of gut microbiota have been discovered to possess significant therapeutic potential, they are defined as next‐generation probiotics (NGPs). Akkermansia , Faecalibacterium Bacteriodes Eubacterium, and Bifidobacteria among typical NGP which exhibit several interesting bioactivities live biotherapeutics. However, some extremely sensitive oxygen, such prausnitzii . This hinders their cultivation large‐scale production. Therefore, it is essential develop a strategy protect them during production, storage, colonic administration. review, highlights key developed in alongside encapsulation strategies used them. The primary criterion for selecting encapsulating techniques feasibility be performed under strictly anaerobic conditions. Various processes selected according physical forms products, including liquid, gel, solid forms, well final shaping product. critical factors materials include biocompatibility, safety, effective oxygen barrier properties, an optimal release profile gastrointestinal tract. review discusses protection aimed at improving survival thereby effectiveness NGPs.

Language: Английский

Optimization and characterization of apple essence microencapsulation utilizing β-cyclodextrin/gum arabic/montmorillonite for fresh-cut apple preservation

Food Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 142732 - 142732

Published: Dec. 1, 2024

Language: Английский