Trinitroglycerine-loaded chitosan nanoparticles attenuate renal ischemia-reperfusion injury by modulating oxidative stress DOI Creative Commons
Zeinab Karimi,

Khatereh Asadi,

Pooran Ghahramani

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

Renal ischemia-reperfusion (I/R) injury is a common clinical factor for acute kidney (AKI). A current study investigated the renoprotective effects of trinitroglycerine (TNG) combination with chitosan nanoparticles (CNPs) on renal I/R-induced AKI. Rats were randomly assigned to five groups (n = 8/group): Sham, I/R, TNG (50 mg/kg) + CNPs (60 and TNG-CNPs I/R. Bilateral pedicles occluded 60 min induce ischemia. TNG, CNPs, or administered intraperitoneally 30 before After 24 h reperfusion, blood samples collected, both kidneys removed. The left was used oxidative stress analysis. right preserved in 10% formalin histopathological examination via H&E staining. injury, there an observed increase plasma creatinine (Cr) urea nitrogen (BUN), accompanied by decrease glomerular filtration rate (GFR) rats. Total (TOS) levels also significantly higher I/R group, whereas total antioxidative capacity (TAC) reduced. Histopathological revealed damage rats group. Pretreatment TNG-CNP formulation increased tissue TAC It corrected changes functional disorders induced as evidenced reduced Cr BUN, GFR, attenuated stress. results suggest that provides against AKI improving antioxidant status minimizing injury.

Language: Английский

Trinitroglycerin-loaded chitosan nanogels accelerate angiogenesis in wound healing process DOI

Khatereh Asadi,

Negar Azarpira, Reza Heidari

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134937 - 134937

Published: Aug. 22, 2024

Language: Английский

Citations

3
Fabrication of injectable, adhesive, self-healing, superabsorbent hydrogels based on quaternary ammonium chitosan and oxidized pullulan DOI Creative Commons
Qianjun He,

Xiaoyue Ding,

Jun Deng

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38577 - e38577

Published: Sept. 27, 2024

Language: Английский

Citations

2
Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation DOI
Sankha Bhattacharya, Shashikant B. Bagade, Preeti C. Sangave

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Language: Английский

Citations

1
Development of a doxepin-loaded chitosan nanogel as an innovative nano platform for oral mucositis treatment DOI
Nazafarin Samiraninezhad, Khatereh Asadi, Reza Heidari

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106430 - 106430

Published: Nov. 1, 2024

Language: Английский

Citations

0
Trinitroglycerine-loaded chitosan nanoparticles attenuate renal ischemia-reperfusion injury by modulating oxidative stress DOI Creative Commons
Zeinab Karimi,

Khatereh Asadi,

Pooran Ghahramani

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

Renal ischemia-reperfusion (I/R) injury is a common clinical factor for acute kidney (AKI). A current study investigated the renoprotective effects of trinitroglycerine (TNG) combination with chitosan nanoparticles (CNPs) on renal I/R-induced AKI. Rats were randomly assigned to five groups (n = 8/group): Sham, I/R, TNG (50 mg/kg) + CNPs (60 and TNG-CNPs I/R. Bilateral pedicles occluded 60 min induce ischemia. TNG, CNPs, or administered intraperitoneally 30 before After 24 h reperfusion, blood samples collected, both kidneys removed. The left was used oxidative stress analysis. right preserved in 10% formalin histopathological examination via H&E staining. injury, there an observed increase plasma creatinine (Cr) urea nitrogen (BUN), accompanied by decrease glomerular filtration rate (GFR) rats. Total (TOS) levels also significantly higher I/R group, whereas total antioxidative capacity (TAC) reduced. Histopathological revealed damage rats group. Pretreatment TNG-CNP formulation increased tissue TAC It corrected changes functional disorders induced as evidenced reduced Cr BUN, GFR, attenuated stress. results suggest that provides against AKI improving antioxidant status minimizing injury.

Language: Английский

Citations

0