Journal of Nanotheranostics,
Journal Year:
2025,
Volume and Issue:
6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
The
nanozymes
(NZs)
are
the
artificial
catalyst
deployed
for
biosensing
with
their
uniqueness
(high
robustness,
surface
tenability,
inexpensive,
and
stability)
obtaining
a
better
response/miniaturization
of
varied
sensors
than
traditional
ancestors.
Nowadays,
nanomaterials
broadened
scale
such
as
metal-organic
frameworks
(MOFs),
metals/metal
oxides
widely
engaged
in
generating
NZ-based
biosensors
(BS).
Diverse
strategies
like
fluorescent,
colorimetric,
surface-enhanced
Raman
scattering
(SERS),
electrochemical
sensing
principles
were
implemented
signal
transduction
NZs.
Despite
broad
advantages,
numerous
encounters
(like
specificity,
feasibility,
stability,
issues
scale-up)
affecting
potentialities
NZs-based
BS,
thus
need
prior
attention
promising
exploration
revolutionary
outcome
advanced
theranostics.
This
review
includes
different
types
NZs,
progress
NZs
tailored
bio-sensing
techniques
detecting
abundant
bio
analytes
theranostic
purposes.
Further,
discussion
highlighted
some
recent
challenges
along
progressive
way
possibly
overcoming
followed
by
commercial
outbreaks.
Developmental medico-life-sciences,
Journal Year:
2024,
Volume and Issue:
1(10), P. 4 - 22
Published: Dec. 13, 2024
Ovarian
cancer
is
one
of
the
most
aggressive
and
deadly
gynaecological
malignancies
remains
frequently
diagnosed
at
advanced
stages
because
its
asymptomatic
progression
inherent
limitations
current
diagnostic
tests.
Nanoenzymes
(a
class
nanotechnology-based
artificial
enzymes)
have
great
promise
in
addressing
these
challenges.
greatly
improve
sensitivity
specificity
biosensors
including
optical
electrochemical
systems,
with
real-time
high-precision
detection
key
biomarkers
such
as
CA-125,
HE4,
mesothelin.
The
high
accuracy
biosensors,
fluorescence
surface
plasmon
resonance
(SPR)
based
technologies,
for
early-stage
diagnosis,
cost-effective,
portable,
ultra-low
limits
make
them
attractive
alternatives.
Nanoenzyme-based
drug
delivery
systems
like
liposomes,
polymeric
micelles,
Nanocapsules
therapeutic
outcomes
by
allowing
targeted
transport
to
tumor
tissues,
reducing
systemic
toxicity,
overcoming
resistance
treatment.
PEGylated
liposomal
doxorubicin
(Doxil),
a
formulation,
has
been
shown
enhanced
efficacy
platinum-resistant
ovarian
cancer,
reduced
adverse
effects.
Further
theranostic
applications
metallic
nanoparticles
gold
iron
oxide
can
be
realized
using
therapy
imaging.
These
advancements
come
their
challenges,
however,
biological
barriers,
scalability
before
clinical
translation.
Interdisciplinary
research,
validation,
creation
regulatory
frameworks
safety
are
needed
future
progress.
offer
revolutionize
diagnosis
treatment
potential
facilitate
early
detection,
precision,
patient
outcome
while
filling
huge
gaps
approaches.
