Diversity of Host Species and Optimized Cultivation Practices for Enhanced Bioactive Compound Production in Cordyceps militaris DOI Creative Commons
Trung Quang Nguyen,

Phan Duong Thuc Quyen,

Nguyễn Thị Ngọc

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8418 - 8418

Published: Sept. 19, 2024

Cordyceps militaris, recognized for its diverse and potent medicinal properties, plays a critical role in herbal medicine. This study investigates the genus Cordyceps, particularly focusing on C. species widely utilized East Asian traditional medicine therapeutic properties. militaris is rich bioactive compounds, including cordycepin, adenosine, polysaccharides, ergosterol, mannitol, which contribute to broad physiological activities. The research aims explore diversity of host cultivation assess their impact biological activity chemical composition fungus. highlights variability efficacy compounds due different conditions species, emphasizing need standardized practices. Advances genetic engineering fermentation technology have significantly enhanced production these metabolites, supporting sustainable scale-up cultivation. Future should continue molecular mechanisms identify new clinical applications, improve efficiency environmental sustainability. comprehensive review provides insights researchers, healthcare professionals, cultivators optimizing commercial applications.

Language: Английский

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology DOI Creative Commons
Trung Quang Nguyen, Pham Văn Thinh, Yusuf Andriana

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 33 - 33

Published: Jan. 3, 2025

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C. militaris-derived bioactive gels applications dermatology and skincare, with particular focus on their anti-aging benefits. In response to rising incidence skin cancers growing demand natural ingredients, has emerged as valuable source functional compounds, including cordycepin, polysaccharides, adenosine. These compounds exhibit multiple bioactivities, apoptosis induction, cell cycle arrest, anti-inflammatory effects, which have been shown be particularly effective against melanoma other cancers. Additionally, antioxidant properties enhance resilience by scavenging reactive oxygen species, reducing oxidative stress, promoting collagen synthesis, thereby addressing health requirements. The incorporating into gel-based formulations skincare also examined, either standalone bioactives or combination synergistic ingredients. Emphasis placed necessity clinical trials standardization establish safety, efficacy, reproducibility such applications. By providing safer alternative synthetic agents, represent promising advancement skincare.

Language: Английский

Citations

1
Green ultrasonic-assisted enzymatic extraction of polysaccharides from Flammulina velutipes residues by response surface methodology DOI

Yiting Yang,

Xiaoxue Zhang, Jingbo Zhang

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 41, P. 101690 - 101690

Published: July 2, 2024

Language: Английский

Citations

6
Musa basjoo Sieb polysaccharide improves inflammation in RAW264.7 cells and zebrafish colitis DOI
Yan Zhang,

Chenchen Zhang,

Manhong Luo

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104471 - 104471

Published: June 4, 2024

Language: Английский

Citations

4
Characterization of gelatin-based composite films loaded with polysaccharide and carbon dots from Stropharia rugosoannulata and their application in pork fresh-keeping DOI
Jintao Wu,

Zhaolan Yan,

Shan Peng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139702 - 139702

Published: Jan. 1, 2025

Language: Английский

Citations

0
Study on the ameliorative effect of marine fungus Hansfordia sinuosae extracellular polysaccharide on DSS-induced ulcerative colitis and depression-like behavior DOI
Wei Wang,

Huiru Li,

Dezhao Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142852 - 142852

Published: April 1, 2025

Language: Английский

Citations

0
Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production DOI Creative Commons

Yu-Chieh Chou,

Ting-Hsuan Sung,

Shi-Jing Hou

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4610 - 4610

Published: May 27, 2024

Cordyceps militaris is a valuable medicinal fungus which has been widely used as traditional medicine in East Asia. Compared to the well-known C. sinensis, can produce similar fermented metabolites with various biological activities, but it requires shorter culture time and simpler conditions, therefore, attracted increasing attention recent years. The purpose of this review was organize current studies regarding metabolite production from relative their functions. We combined findings correlate different fermentation modes obtain full view processes yield product. While research on not uncommon date, its high value still highlights importance developing more modern for industrial production.

Language: Английский

Citations

3
Therapeutic Potential of Mushrooms: A Review on NF-κB Modulation in Chronic Inflammation DOI
Nur Amalina Amirullah, Erlina Abdullah,

Nurhayati Zainal Abidin

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105059 - 105059

Published: Sept. 6, 2024

Language: Английский

Citations

3
Plasma metabolites as potential markers and targets to prevent and treat urolithiasis: a Mendelian randomization study DOI Creative Commons

Wuhui Zhu,

Huan Li, Ming Zhang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 27, 2024

Background Studies on the relationships between diseases of urinary system and human plasma proteomes have identified several potential biomarkers. However, none these studies elucidated causal proteins urolithiasis. Objective The objective study was to investigate risks metabolites in urolithiasis using a two-sample Mendelian randomization (MR) study. Methods A total 1,400 were most comprehensive genome-wide association (GWAS) metabolomics European population date, single-nucleotide polymorphisms (SNPs) used as instrumental variables for metabolites. GWAS data calculi included 482,123 case samples 6,223 control (ebi-a-GCST90018935). associations risk evaluated by inverse variance weighting (IVW) supplemented sensitivity analyses MR-Egger MR-PRESSO tests. Results For first time, we found relationship two ( p < 1.03 × 10 −4 ) 0.05). chemical 4-hydroxychlorothalonil, which is an intermediate product pesticide hydroxychlorothalonil, could promote (odds ratio (OR) = 1.12) factor. Moreover, 1-stearoyl-2-arachidonoyl-GPC, important component phospholipid metabolism body, can inhibit (OR 0.94). Conclusions Our results suggest that blood be markers drug targets prevention, diagnosis, treatment urolithiasis; furthermore, our provide basis policy makers formulate prevention policies

Language: Английский

Citations

1
Diversity of Host Species and Optimized Cultivation Practices for Enhanced Bioactive Compound Production in Cordyceps militaris DOI Creative Commons
Trung Quang Nguyen,

Phan Duong Thuc Quyen,

Nguyễn Thị Ngọc

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8418 - 8418

Published: Sept. 19, 2024

Cordyceps militaris, recognized for its diverse and potent medicinal properties, plays a critical role in herbal medicine. This study investigates the genus Cordyceps, particularly focusing on C. species widely utilized East Asian traditional medicine therapeutic properties. militaris is rich bioactive compounds, including cordycepin, adenosine, polysaccharides, ergosterol, mannitol, which contribute to broad physiological activities. The research aims explore diversity of host cultivation assess their impact biological activity chemical composition fungus. highlights variability efficacy compounds due different conditions species, emphasizing need standardized practices. Advances genetic engineering fermentation technology have significantly enhanced production these metabolites, supporting sustainable scale-up cultivation. Future should continue molecular mechanisms identify new clinical applications, improve efficiency environmental sustainability. comprehensive review provides insights researchers, healthcare professionals, cultivators optimizing commercial applications.

Language: Английский

Citations

1