Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing DOI Creative Commons
Sindi P. Ndlovu, Keolebogile Shirley Motaung, Mapula Razwinani

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1313 - 1313

Published: Oct. 10, 2024

: Effective wound dressing is the key solution to combating increased death rate and prolonged hospital stay common patients with wounds.

Language: Английский

Natural polysaccharide-based hydrogels for hemostasis and wound healing: A review DOI Creative Commons
Peng Wang, Yuji Pu, Bin He

et al.

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100016 - 100016

Published: Jan. 1, 2025

Language: Английский

Citations

1
Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections DOI Creative Commons
Wanhe Luo, Mengdi Zhang, Yongtao Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 541 - 555

Published: Jan. 1, 2025

The difficulty of establishing slow release at intestinal infection sites, weak antibacterial effects, as well the limited broad use florfenicol oral formulations are main targets current study. Novel hydrogels derived from sodium alginate were developed using a complexation form for delivery to achieve site and enhance its activity against Escherichia coli. optimal formulation, physicochemical properties, stability, pH-responsive performance, activity, in vitro biosafety have been studied systematically. created had consistent spherical morphology, with an average diameter 531.9±12.6 nm. Energy dispersive spectroscopy Fourier transform infrared indicated that successfully prepared through force. Furthermore, it is shown hold outstanding excellent sustained release, faster swelling pH due pH-responsiveness. no obvious structural destruction simulated gastric juice (pH=1.2) 12 hrs highly stable. However, began be destroyed after 5 minutes fluid (SIF), this decomposition was continuous. With structure hydrogels, encapsulated also slowly released, thus, achieves slow-release effect. Additionally, showed low hemolytic ratio greater compared florfenicol. blended formulation creates promising matrix intended along gastrointestinal tract.

Language: Английский

Citations

0
Network‐Remodeling, Electroactive and Antibacterial Cryogel with Tissue Sealing and Pro‐Coagulant Activity for Hemostasis and Skin Wound Healing DOI Open Access

Jinlong Luo,

Zhengying Wu,

Xin Zhao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Developing network‐remodeling, electroactive and antibacterial cryogel with tissue sealing pro‐coagulant activity for wound repair hemostasis remains challenging. Here, quaternized chitosan‐graft‐polyaniline (QCSP), oxidized dextran (OD), benzaldehyde‐terminated Pluronic F127 are used to prepare dressings (QP/OD/PF) network remodeling, electroactivity, antibacterial, antioxidation, blood concentration effect via in situ dual Schiff base crosslinking. The exhibits conductivity remodeling after water absorption demonstrates degradation, rapid swelling, excellent adhesion, biocompatibility, photothermal property. Besides, the hemostatic property of is confirmed mouse liver puncture bleeding model, rat cruciate incision perforation model. effect, as well activation platelets cells by cryogel, confirmed. This functionality successfully utilized biologically active clot/cryogel composite dressing (B‐QP/OD/PF) further promote skin healing. All results closure ratio, histological examination, immunofluorescence staining, collagen deposition confirm that B‐QP/OD/PF superior QP/OD/PF other groups promoting full‐thickness defect opens up a new direction development

Language: Английский

Citations

0
A multifunctional highly adhesive hydrogel mimicking snail mucus for hemostatic coating DOI

Jingjing Yuan,

Ming He, Jueying Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160110 - 160110

Published: Jan. 1, 2025

Language: Английский

Citations

0
Double-Network Hydrogel Based on Methacrylated Chitosan/Hyaluronic Acid Coacervate for Enhanced Wet-Tissue Adhesion DOI

Dafeng Deng,

Deyi Peng,

Jianhua Lv

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Developing robust wet tissue adhesives remains challenging due to interfacial water and irregular surfaces. While polyelectrolyte coacervates demonstrate promising hydrophobic/fluidic properties for adhesion, their low cohesion limits practical applications. Herein, a bioadhesive based on formed from low- molecular-weight methacrylated chitosan (CSMA) hyaluronic acid (HA) is reported. These homogeneous transparent displayed high solid content (∼18.0%), fluidity (∼105 mPa·s), tunable mechanical properties. Upon application surfaces, the coacervate can be photo-cross-linked form double-network hydrogel in situ, resulting improved durable adhesion. The CSMA-HA demonstrated adhesion tissues, with bursting pressure of 374 mmHg. Remarkably, further enhanced (∼623 mmHg) after 24 h PBS immersion dynamic bond reorganization swelling. stability under physiological conditions position as transformative platform adhesive

Language: Английский

Citations

0
Crop resilience enhancement through chitosan-based hydrogels as a sustainable solution for water-limited environments DOI
Nurdiana Nordin, Walid A. Afifi, S.R. Majid

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137202 - 137202

Published: Nov. 1, 2024

Language: Английский

Citations

1
Sodium alginate/carboxymethylcellulose gel formulations containing Capparis sepieria plant extract for wound healing DOI
Sindi P. Ndlovu, Keolebogile Shirley Motaung, Samson A. Adeyemi

et al.

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: 15(12), P. 921 - 937

Published: Nov. 12, 2024

Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.

Language: Английский

Citations

1
Zeolitic Imidazolate Framework-8 Nanocomposite Hydrogels for Diabetic Wound Healing DOI

Junran Yang,

Xinglong Liu,

Yan Tang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

To avoid the problem of difficult wound healing caused by diabetes. In this study, zeolite imidazolium ester skeleton-8 (ZIF-8) was loaded with dihydroquercetin (DHQ) in order to improve slow-release property as well biological activity DHQ, and mechanism action ZIF-8-loaded hydrogel investigated Western blot technique. The results showed that dynamic light scattering result 90.54 ± 3.45 nm zeta potential −32.91 mV. addition, through synergistic effect ZIF-8 exhibited excellent vitro activity, antioxidant inhibition rate DZP against free radicals ABTS DPPH over 90%, Escherichia coli Staphylococcus aureus respectively, also promoted cell growth migration. release assay DHQ from at 24 h 61.69 1.93% pH = 6.0 62.42 1.58% 7.4, which improves is suitable for long-term tissue repair applications. vivo experiments promotes difficult-to-heal wounds inhibiting activation IkBα/NF-κB pathway, stimulating skin neovascularisation, promoting collagen accumulation. Collectively, these properties make a strong candidate diabetic dressings are expected play an important role management.

Language: Английский

Citations

1
Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing DOI Creative Commons
Sindi P. Ndlovu, Keolebogile Shirley Motaung, Mapula Razwinani

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1313 - 1313

Published: Oct. 10, 2024

: Effective wound dressing is the key solution to combating increased death rate and prolonged hospital stay common patients with wounds.

Language: Английский

Citations

0