Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 207 - 207

Published: Jan. 7, 2025

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.

Language: Английский

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Synthesis of novel chitosan-Schiff bases nanoparticles for high efficiency Helicobacter pylori inhibition

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133499 - 133499

Published: June 27, 2024

Language: Английский

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Eco-friendly synthesis of ZnO/chitosan nanocomposite: Detailed characterization, DFT study, docking study, adsorption kinetics, thermodynamic analysis and antioxidant properties

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 425, P. 127216 - 127216

Published: Feb. 28, 2025

Language: Английский

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Designing a β-nitrostyrene derived chitosan Schiff base with potent antimicrobial and antioxidant activities and drug delivery applications

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101650 - 101650

Published: Feb. 1, 2025

Language: Английский

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Chitosan and its derivatives as potential biomaterials for biomedical and pharmaceutical applications: A comprehensive review on green extraction approaches, recent progresses, and perspectives

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113882 - 113882

Published: March 1, 2025

Language: Английский

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Preparation of novel thiolated chitosan with significant antioxidant activity

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142536 - 142536

Published: March 1, 2025

Language: Английский

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Dopamine-conjugated Hyaluronic Acid Hydrogel Interpenetrated by Genipin Crosslinked Quaternary Ammonium Chitosan for Potential Biomedical Adhesives Applications

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114683 - 114683

Published: April 1, 2025

Language: Английский

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Chitosan-Based Schiff Base Compounds: Synthesis, Chemical Characterization and Antibacterial Properties

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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The Amyloid Beta Aggregation Inhibition Properties of New Pt (II) Complexes and Their Potential in Alzheimer's Treatment

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 10, 2025

ABSTRACT In this study, N‐phenylortho‐phenylenediamine and N‐phenyl ethylenediamine were utilized as amines, two novel ligands, benzimidazole (LI) Schiff base (LII), synthesized through condensation reactions with 3‐methoxy‐4‐benzyloxybenzaldehyde. Furthermore, using these same LIII (benzimidazole) 3‐phenoxybenzaldehyde LIV (Schiff base) 4‐benzyloxybenzaldehyde in accordance the literature. Then, Pt (II) complexes (Ia, Ib, II, III, IV) prepared it was determined that Ia Ib are geometric isomers. The ligands characterized 1 H‐NMR, 13 C‐NMR, FT‐IR, elemental analysis methods. cytotoxic effects of evaluated on SH‐SY5Y neuronal cells. Low‐toxicity Ia, IV then tested for their ability to inhibit amyloid beta (Aβ 1–42 ) aggregation. Thioflavin T fluorescence analysis, AFM imaging, MALDI‐TOF mass spectrometry demonstrated complexes, particularly at a 1:1 complex‐to‐amyloid molar ratio, effectively inhibited Aβ These findings suggest containing may be effective against Alzheimer's disease by alleviating toxicity.

Language: Английский

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Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β_1–42 Aggregation

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(8)

Published: June 3, 2024

For synthesizing metal–organic molecules with pro‐drug properties to prevent the accumulation of amyloid beta (Aβ 1–42 ), which is a feature neurodegenerative Alzheimer's disease, two new Schiff bases imine/amine donors 2‐([3,3‐diphenylalidene]amino)‐N,N‐dimethylethane‐1‐amine and N,N‐dimethyl‐2‐([quinolin‐4‐ylmethylene]amino)ethane‐1‐amine, as well their novel Pt (II) complexes (I II), were synthesized characterized via Fourier transform infrared spectroscopy, 1 H‐ 13 C‐nuclear magnetic resonance (NMR) mass spectrometry, elemental analyses. The spectroscopic data has shown that ligands are coordinated central atom in chelating manner. Furthermore, interaction between these Aβ was investigated using electrochemical methods, square wave voltammetry pencil graphite electrode, while monitoring changes oxidation signal Try residue 1–42. ability compounds inhibit aggregation human neuroblastoma cell line (SH‐SY5Y). Complex II could actively at molar ratio 1.0/1.0, its kinetics fluorometrically determined thioflavin T. These results supported by scanning electron microscopy transmission Moreover, complex 1–16 H‐NMR spectroscopy. As result, it observed effective inhibiting Aβ1–42 1.0/1.0. This result shows studies can be conducted on effects base‐Pt potential pro‐drugs disease.

Language: Английский

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