Functional biomass/biological macromolecular phase change composites and their applications in different scenarios: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141377 - 141377

Published: Feb. 1, 2025

Language: Английский

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Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

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Zn‐DHM Nanozymes Enhance Muscle Regeneration Through ROS Scavenging and Macrophage Polarization in Volumetric Muscle Loss Revealed by Single‐Cell Profiling

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Volumetric muscle loss (VML) is a severe condition in which the of skeletal surpasses body's intrinsic repair capabilities, leading to irreversible functional deficits and potential disability, with persistent inflammation impaired myogenic differentiation. To address these challenges, novel zinc‐dihydromyricetin (Zn‐DHM) nanozyme superoxide dismutase (SOD)‐like activity developed, designed neutralize excessive reactive oxygen species (ROS) restore oxidative balance. Zn‐DHM mitigates stress promotes polarization macrophages from proinflammatory M1 phenotype anti‐inflammatory M2 phenotype, thereby reducing chronic creating conducive environment for repair. Further, significantly enhances differentiation C 2 12 cells, accelerating wound healing processes. These studies confirm biosafety low toxicity Zn‐DHM. As per murine tibialis anterior VML model, effectively suppresses markedly improves outcomes. Single‐cell RNA sequencing reveals that treatment increases expression macrophage markers proliferation capacity stem cells (MuSCs). In addition, intercellular communication analysis interactions between MuSCs group, suggesting may drive tissue regeneration through activation GAS Notch signaling pathways.

Language: Английский

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Nanotherapeutic and Nano–Bio Interface for Regeneration and Healing

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2927 - 2927

Published: Dec. 23, 2024

Wound and injury healing processes are intricate multifaceted, involving a sequence of events from coagulation to scar tissue formation. Effective wound management is crucial for achieving favorable clinical outcomes. Understanding the cellular molecular mechanisms underlying healing, inflammation, regeneration essential developing innovative therapeutics. This review explored interplay contributing focusing on innervation, angiogenesis, role cell surface adhesion molecules. Additionally, it delved into significance calcium signaling in skeletal muscle its implications regenerative medicine. Furthermore, therapeutic targeting senescence long-term was discussed. The integration cutting-edge technologies, such as quantitative imaging computational modeling, has revolutionized current approach dynamics. also highlighted nanotechnology engineering medicine, particularly development nanomaterials nano–bio tools promoting regeneration. Moreover, emerging interfaces facilitate efficient transport biomolecules Overall, this provided insights regeneration, emphasizing interdisciplinary approaches technologies advancing therapies. Through harnessing potential nanoparticles, bio-mimetic matrices, scaffolds, medicine offers promising avenues restoring damaged tissues with unparalleled precision efficacy. pursuit marks significant departure traditional approaches, offering addressing longstanding challenges repair, thereby significantly advancement

Language: Английский

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Investigation of scaffold manufacturing conditions for 3-dimensional culture of myogenic cell line derived from black sea bream (Acanthopagrus schlegelii)

Cytotechnology, Journal Year: 2024, Volume and Issue: 77(1)

Published: Dec. 12, 2024

Language: Английский

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