The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer's disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K/Akt signaling pathways

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102416 - 102416

Published: July 13, 2024

Language: Английский

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Ferula latisecta gels for synthesis of zinc/silver binary nanoparticles: antibacterial effects against gram-negative and gram-positive bacteria and physicochemical characteristics

BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 1, 2024

Abstract This study explores the potential antibacterial applications of zinc oxide nanoparticles (ZnO NPs) enhanced with silver (Ag) using plant gel (ZnO-AgO NPs). The problem addressed is increasing prevalence pathogenic bacteria and need for new, effective antimicrobial agents. ZnO NPs possess distinctive physicochemical properties that enable them to selectively target bacterial cells. Their small size high surface area-to-volume ratio allow efficient cellular uptake interaction In this study, average synthesized ZnO-Ag was 77.1 nm, a significant standard deviation 33.7 indicating wide distribution. demonstrated remarkable efficacy against gram-negative gram-positive bacteria, inhibition zones 14.33 mm E. coli 15.66 B. subtilis at concentration 300 µg/ml. Minimum inhibitory concentrations (MIC) were determined be 100 µg/ml 75 S. saprophyticus . Additionally, exhibited excellent biocompatibility, making appropriate various pharmacological uses. utilizes Ferula latisecta gels, offering sustainable eco-friendly approach nanoparticle synthesis. Incorporating Ag into significantly enhances their properties, combined results showing great effects on microbes. findings suggest could promising candidate addressing challenges posed by drug-resistant infections enhancing treatments.

Language: Английский

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Insect resistance responses of ten Aster varieties to damage by Tephritis angustipennis in the three rivers source region of China

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Aster varieties are widely used for medicinal purposes, landscaping, and ecological restoration, but their growth reproduction significantly threatened by the seed predator Tephritis angustipennis (Diptera: Tephritidae). The cultivation of pest-resistant offers an effective, economical, eco-friendly approach to managing T. infestations. This study evaluates impact on ten in Three Rivers Source Region (TRSR), with a focus population density, plant damage rate, activity resistance enzymes insect-resistant metabolites. results classified into four groups: one highly resistant variety [HR: altaicus (MQAA)], moderately [MR: asteroides (DRAA), flaccidus (QLAF), tongolensis (BMAT), poliothamnus (MQAP)], two susceptible [MS: diplostephioides (QLAD), souliei (DRAS)], three [HS: A. (MQAD), yunnanensis var. labrangensis (MQAY), farreri (MQAF)]. Notably, HR MR exhibited higher activities catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), phenylalanine ammonia lyase (PAL), polyphenol oxidase (PPO), trypsin inhibitor (TI), chymotrypsin (CI), as well contents tannins (TN) flavonoids (FN), compared MS HS varieties. Specifically, (MQAA) showed highest levels CAT, POD, SOD, TN, enhancing its angustipennis. Statistical analyses further revealed that MDA, FN, antioxidant enzyme were found be key factors influencing insect across different levels. These findings enhance our understanding physiological biochemical mechanisms underlying spp. offer valuable insights developing integrated pest management strategies. By identifying promoting varieties, this lays groundwork sustainable control measures protect crops from damage.

Language: Английский

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Melatonin-loaded lecithin and chitosan nanoparticles are cytotoxic to 4 T1 breast cancer cells and safe in a BALB/c mouse model

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143401 - 143401

Published: April 1, 2025

Language: Английский

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