Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108069 - 108069
Published: Dec. 16, 2024
Language: Английский
Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)
Published: Jan. 1, 2025
ABSTRACT Alterations in glycoconjugate profiles are thought to promote changes cell‐to‐cell and cell‐to‐intracellular extracellular scaffold interactions human disease. The nearly unlimited number of “glycoforms” that may exist nature difficult study due glycosylation modifications being associated with non‐genome coded posttranscription post‐translation processes. Specific products generated by dependent on concentration sub‐cellular locations glycan synthesis processing enzymes. An indirect “high‐throughput” approach is characterize enzymes (hydrolases transferases) single cell sequencing all types tissue diseases. We previously identified TMEM230 as an endoplasmic reticulum (ER) protein regulates NOTCH glycoprotein receptor ligand signaling zebrafish blood vessel formation destructive remodeling capacities diverse including fibroblast, phagocytic immune system cells patients cancer or granulomatous systemic vasculitis autoimmune disorder. represents a paradigm mediated signal transduction supports the role modifications. ER initiates earliest steps synthesis, sorting, trafficking. As remodeling, Notch hallmarks disorders, we investigated whether aberrant expression was also rheumatoid arthritis (RA). In this current study, analysis supported downregulated synovial RA while were predominantly upregulated. contrast, upregulated high‐grade compared low‐grade gliomas it N‐linked (GlcNAc), glycosaminoglycan expression. Our collective results support glycan/glycoconjugate aggressive gliomas. therefore be therapeutic target marker for clinical treatment induced autoimmunity disorders cancer.
Language: Английский
Citations
1
Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1735, P. 465318 - 465318
Published: Aug. 31, 2024
Language: Английский
Citations
6
Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)
Published: April 8, 2025
Glycosylation is a ubiquitous biochemical process that covalently attaches glycans to proteins or lipids, which plays pivotal role in modulating the structure and function of these biomolecules. This post-translational modification prevalent living organisms intricately regulates various biological processes, including signaling transduction, recognition, immune responses. In oral environment, bacteria ingeniously use glycosylation enhance their adhesion surfaces, key step biofilm formation subsequent development. intimately associated with onset progression diseases, dental caries periodontal disease. review aims describe types mechanisms bacteria, understand adhesion, virulence bacteria. We reviewed articles on variety cariogenic periodontopathic pathogens, facilitates maturation tooth surface. Distinct patterns shape function, influencing microbial interactions community stability. Pathogen-specific signatures ecological competitiveness, contributing disease progression. critical bacterial interactions, significant implications for health
Language: Английский
Citations
0
Journal of Cancer Biology, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 9
Published: April 23, 2025
There is an emerging awareness in cancer biology that glycobiology plays a significant, if not decisive role oncogenesis, tumor survival, and proliferation. The human glycome even more complex than the genome, because glycans are synthesized as secondary gene products by sequentially acting glycosidases glycosyltransferases. Glycans act communication system within organism between different organisms. In principle, nanotechnology has potential of amplifying glycan interaction. By using physical chemical properties nanoparticular systems, glyconanoparticles have revolutionized biomedical research developing platforms for therapy, drug delivery, immunotherapy, biosensing bioimaging. Here we comment on most used glycans, nanomaterials glyconanotechnology, along with new insights.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137442 - 137442
Published: Nov. 8, 2024
Language: Английский
Citations
1
Animal nutrition, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
The current study aims to investigate the potential interaction between glycosylation profiles of Ningxiang breed (NX) and Western Duroc × Landrace Yorkshire (DLY) weaned piglets, their characteristic microbes, employing integrated analyses transcriptomics metagenomics. Twenty-four (12 NX 12 DLY) at 28 days age were transported into an experimental house fed same piglet diet. trail period was 7 days. Results revealed that piglets had a higher growth-to-feed ratio, body weight gain scale, lower pathological score intestinal injury compared with DLY (P < 0.01). displayed elevated mRNA expression levels MUC2 MUC5AC in colonic mucosal tissue than 0.05). Within O-linked glycosylated differentially expressed genes (DEGs), FNTA, GALNT18, POMGNT1, POMGNT2, POMT1 significantly upregulated relative Conversely, C1GALT2, GALNT1, KMT2C, OGT downregulated KMT2C gene hardly transcriptome piglets. At phylum taxonomic level, abundance Firmicutes, while Proteobacteria. genus Lactobacillus, whereas Collinsella, Enterococcus Escherichia. results correlation differential bacteria O-chain DEG showed GALNT1 KMT2 associated Lactobacillus_pontis positive (R = 0.67). Through comparative analysis functions, this highlights role reduced genes, involved protein glycan reactions, impairing barrier function Furthermore, members Lactobacillus Prevotella genera may actively contribute regulation colon profiles.
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108069 - 108069
Published: Dec. 16, 2024
Language: Английский
Citations
0