Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex DOI Creative Commons

AbdulAziz A. Alayyafi,

Kholoud Z. Ghanem,

Masoud Almarri

et al.

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 31, 2025

Copper–indometacin (Cu-Indo) complex was prepared and X-ray diffraction, IR analysis, UV–V spectrophotometric analysis thermal of the formed were used to characterize it. The formation constants for complexation CuCl2.2H2O indometacin in methanol, ethanol, their binary mixture with water determined by conductometric technique. Three stoichiometric complexes copper–indometacin (1/2), (1/1), (2/1) (M/L) detected (Kf) estimated using method Gibbs free energy change (ΔGf) also estimated. antimicrobial activities have been studied disc diffusion against Gram-negative bacteria (P. aeruginosa, E. coli, K. pneumoniae), Gram-positive (S. aureus, B. cereus, S. epidermidis), fungi (C. albicans). In has a larger inhibitory zone (Gram-positive bacteria). As result, it can be utilized treat cereus (cytotoxicity testing not conducted this study).

Language: Английский

Conductometric, physico-chemical, and biological activity investigations of a copper–indometacin complex DOI Creative Commons

AbdulAziz A. Alayyafi,

Kholoud Z. Ghanem,

Masoud Almarri

et al.

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 31, 2025

Copper–indometacin (Cu-Indo) complex was prepared and X-ray diffraction, IR analysis, UV–V spectrophotometric analysis thermal of the formed were used to characterize it. The formation constants for complexation CuCl2.2H2O indometacin in methanol, ethanol, their binary mixture with water determined by conductometric technique. Three stoichiometric complexes copper–indometacin (1/2), (1/1), (2/1) (M/L) detected (Kf) estimated using method Gibbs free energy change (ΔGf) also estimated. antimicrobial activities have been studied disc diffusion against Gram-negative bacteria (P. aeruginosa, E. coli, K. pneumoniae), Gram-positive (S. aureus, B. cereus, S. epidermidis), fungi (C. albicans). In has a larger inhibitory zone (Gram-positive bacteria). As result, it can be utilized treat cereus (cytotoxicity testing not conducted this study).

Language: Английский

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