Targeting STING to disrupt macrophage-mediated fibrosis in encapsulating peritoneal sclerosis. DOI Creative Commons
Hui Peng, Juan Sun, Yuxiang Sun

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from limited understanding its underlying mechanisms. In this study, we developed modified mouse model PD-induced investigated the role STING signaling pathway in disease progression. Our findings reveal that activation mesothelial cells significantly increases secretion macrophage chemokine CCL2, leading to enhanced infiltration formation pathological adhesions. Notably, pharmacological inhibition using inhibitor H151 effectively reduced fibrosis, demonstrating therapeutic potential alleviating EPS. These results identify as critical mediator pathogenesis suggest inhibitors could offer promising strategy prevent or reverse EPS, particularly clinical settings such dialysis.

Language: Английский

Targeting STING to disrupt macrophage-mediated fibrosis in encapsulating peritoneal sclerosis. DOI Creative Commons
Hui Peng, Juan Sun, Yuxiang Sun

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from limited understanding its underlying mechanisms. In this study, we developed modified mouse model PD-induced investigated the role STING signaling pathway in disease progression. Our findings reveal that activation mesothelial cells significantly increases secretion macrophage chemokine CCL2, leading to enhanced infiltration formation pathological adhesions. Notably, pharmacological inhibition using inhibitor H151 effectively reduced fibrosis, demonstrating therapeutic potential alleviating EPS. These results identify as critical mediator pathogenesis suggest inhibitors could offer promising strategy prevent or reverse EPS, particularly clinical settings such dialysis.

Language: Английский

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