Development and In Vitro characterization of Azadirachta Indica Gum grafted polyacrylamide Based pH‐Sensitive Hydrogels to improve the Bioavailability of Lansoprazole DOI Open Access
Muhammad Abid Mustafa, Hafiz Rashid Hussain, Jawad Akbar Khan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract The present study intended to develop a pH‐responsive hydrogel based on Neem gum (Ng) improve Lansoprazole (LSP) oral bioavailability. Azadirachta Indica seed extract was used obtain Ng. formulations (F1–F9) were prepared using different Ng ratios, Acrylamide (AAm), and methylene‐bis‐acrylamide (MBA). formulated hydrogels characterized through FTIR, thermal analysis, swelling ratio, SEM, sol‐gel In‐Vitro drug release, cytotoxicity analysis. extracted produce powder containing 21.5 % Prepared showed maximum at pH 7.4, whereas the an acidic insignificant. LSP‐loaded demonstrated regulated release of LSP for up 24 h indicated Super Case II transport mechanism. During cytotoxic evaluation, delivery system minimal towards normal cells, while percent carried out longer duration (up 96 h). revealed indica gum‐based as promising technique precisely delivering LSP.

Language: Английский

Development of Mn3O4 nanoparticles and Justicia adhatoda extract incorporated Carboxymethyl cellulose/Carbopol hydrogels: Rheological and in vitro bioactivity for sustained drug delivery system DOI
Karolinekersin Enoch, Anbumozhi Angayarkanni Somasundaram

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141713 - 141713

Published: March 1, 2025

Language: Английский

Citations

0
Design and Application of Stimuli‐Responsive Nanocomposite Hydrogels: A Review DOI Open Access
Xiaohan Guo, Huan Liu,

Aminov Nail

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract In order to improve the disadvantages of traditional hydrogels such as low mechanical strength and lack responsiveness, different types nanoparticles or nanostructures are added into hydrogel network through in situ polymerization, self‐assembly techniques, other strategies, giving a variety special properties, stimulation sensitivity, optical electrical reversibility. With development nano materials synthesis technology, nanocomposite have shown great potential drug delivery, tissue engineering, motion detection, wastewater treatment, been extensively studied recent years. This review comprehensively elucidates state‐of‐the‐art preparation strategies underlying response mechanisms diverse stimulus‐responsive hydrogels, spanning temperature, pH, humidity, electrical, light responses. It systematically dissects their applications biomedicine, environmental remediation, flexible sensing, composite phase change materials. Moreover, it delves future prospects challenges, emphasizing need for continuous innovation unlock full emerging fields address existing limitations.

Language: Английский

Citations

0
Evaluation of Dual Drug Delivery Efficiency of Nanocomposite Hydrogel Containing Pectin for Combating Cancer DOI Open Access
Amos Luanda,

Manohar Mahadev,

R. Narayana Charyulu

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

ABSTRACT Traditional chemotherapeutic approaches for cancer treatment often face challenges, such as limited bioavailability and efficacy of anticancer drugs due to a lack specificity quick metabolism. In this study, nanocomposite hydrogel, namely pectin‐ graft ‐poly(4‐acryloylmorpholine‐ co ‐2‐acrylamido‐2‐methyl‐1‐propanesulphonic acid) embedded with silver nanoparticles (Pec‐ g ‐poly(AcM‐ ‐AMPS)‐SNPs) was developed dual drug delivery system treatment. The the neat gel without (SNPs) were characterized using various techniques evaluated their efficiencies co‐delivery 5‐fluorouracil (5‐FU) doxorubicin (DOX) model drugs. exhibited pH‐responsive swelling behavior, comparatively higher observed nanocomposite, maximum at pH 7.4. process obeyed pseudo‐second‐order kinetic model. A similar observation made regarding release drugs, significantly About 83.9% 5‐FU 73.3% DOX released from 7.4 during 8 h. profile adhered first‐order Higuchi‐square root models. transport incorporated out matrix into dissolution medium be Fickian diffusion process. has been proven cytocompatible, demonstrated by cytotoxicity study carried MCF‐10A cells, suggesting its suitability oral combating cancer.

Language: Английский

Citations

0
Development of Pectin‐graft‐poly(4‐acryloylmorpholine) Embedded with Silver Nanoparticles as a Dual Drug Delivery System for Sustained Release of 5‐Fluorouracil and Curcumin DOI Open Access
Amos Luanda,

Manohar Mahadev,

R. Narayana Charyulu

et al.

Macromolecular Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Abstract This study reports the preparation of pectin‐ graf t‐poly(4‐acryloylmorpholine) silver nanocomposite hydrogel (Pec‐ g ‐PAcM‐AgNPs) as a dual drug delivery system (DDDS) for sustained release 5‐fluorouracil (5‐FU) and curcumin (CUR). The matrix material was made in aqueous medium characterized by various techniques. Higher swelling were observed at pH 7.4 than 1.2. loading efficiency determined to be 39.1 mg −1 5‐FU 42.8 CUR. About 93.9% 72.2% CUR released from during 24 h. kinetics mechanism best fitted first‐order kinetic Higuchi square rootmodels, respectively. adhered Fickian non‐Fickian diffusion mechanism, cell viability drug‐loaded above 85%, indicating cytocompatibility developed polymer matrix. results highlight potential prepared suitable DDDS enhancing bioavailability gastrointestinal tract cancer therapy.

Language: Английский

Citations

0
Locust bean gum-based silver nanocomposite hydrogel as a drug delivery system and an antibacterial agent DOI
Amos Luanda,

Manohar Mahadev,

R. Narayana Charyulu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137097 - 137097

Published: Oct. 1, 2024

Language: Английский

Citations

3
Polymers Enhance Chlortetracycline Hydrochloride Solubility DOI Open Access
Chao Zhang, Bing Li, Yubin Bai

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10591 - 10591

Published: Oct. 1, 2024

Chlortetracycline hydrochloride (CTC) is a broad-spectrum tetracycline antibiotic with wide range of antibacterial activities. Due to low solubility, poor stability, and bioavailability, clinical preparation development limited. We sought improve these solubility dissolution rates by preparing solid dispersions. A hydrophilic polymer was selected as the carrier, dispersion prepared using medium grinding method, samples characterized scanning electron microscopy (SEM), differential calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), particle size distribution (PSD). To maximize CTC different types optimal drug-to-polymer ratios were screened. The optimized povidone K30 (PVPK30) (1/0.75, w/w)-, hydroxypropyl-β-cyclodextrin (HP-β-CD) (1/2, gelatin (1/1, w/w)-based dispersions 6.25-, 7.7-, 3.75-fold higher than that pure powder, respectively. Additionally, in vitro studies showed gelatin-based had initial rate. SEM PS analyses confirmed this smaller more uniform particles PVPK30 HP-β-CD Therefore, successful preparations improved rates, which may have potential drug delivery systems.

Language: Английский

Citations

0
Harnessing Natural Inhibitors of Protein Synthesis for Cancer Therapy: A Comprehensive Review DOI Creative Commons
Liqin Liu, Zhihui Li, Wenshuang Wu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107449 - 107449

Published: Oct. 4, 2024

Cancer treatment remains a formidable challenge in modern medicine, necessitating nuanced understanding of its molecular underpinnings and the identification novel therapeutic modalities. Among intricate web cellular pathways implicated oncogenesis, protein synthesis has emerged as fundamental process warranting meticulous investigation. This review elucidates multifaceted role tumor initiation progression, highlighting potential targeting key nodes within these viable strategies. Natural products have long served source bioactive compounds with owing to their structural diversity evolutionary honing. Within this framework, we provide thorough examination natural inhibitors promising candidates for cancer therapy, drawing upon recent advancements mechanistic insights. By synthesizing current evidence elucidating challenges opportunities, aims galvanize further research into development product-based anticancer therapeutics, thereby advancing clinical armamentarium against malignancies.

Language: Английский

Citations

0
Development and In Vitro characterization of Azadirachta Indica Gum grafted polyacrylamide Based pH‐Sensitive Hydrogels to improve the Bioavailability of Lansoprazole DOI Open Access
Muhammad Abid Mustafa, Hafiz Rashid Hussain, Jawad Akbar Khan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract The present study intended to develop a pH‐responsive hydrogel based on Neem gum (Ng) improve Lansoprazole (LSP) oral bioavailability. Azadirachta Indica seed extract was used obtain Ng. formulations (F1–F9) were prepared using different Ng ratios, Acrylamide (AAm), and methylene‐bis‐acrylamide (MBA). formulated hydrogels characterized through FTIR, thermal analysis, swelling ratio, SEM, sol‐gel In‐Vitro drug release, cytotoxicity analysis. extracted produce powder containing 21.5 % Prepared showed maximum at pH 7.4, whereas the an acidic insignificant. LSP‐loaded demonstrated regulated release of LSP for up 24 h indicated Super Case II transport mechanism. During cytotoxic evaluation, delivery system minimal towards normal cells, while percent carried out longer duration (up 96 h). revealed indica gum‐based as promising technique precisely delivering LSP.

Language: Английский

Citations

0