Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 207 - 207

Published: Jan. 7, 2025

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.

Language: Английский

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Biologically active ionic chitosan Schiff base nanocomposites: Synthesis, characterization and antimicrobial activity against Helicobacter pylori

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137321 - 137321

Published: Nov. 6, 2024

Language: Английский

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Octyl succinic anhydride-modified chitosan/oxidized sodium alginate Schiff base hydrogel loaded with terbinafine hydrochloride: pH-responsive, self-repairing, antifungal properties

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140431 - 140431

Published: Jan. 28, 2025

Language: Английский

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Multi-Level Drug Delivery System Integrated with Injectable Hydrogels and ZIF-8 for Sustained Release of Lidocaine

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 3 - 3

Published: Feb. 14, 2025

Lidocaine plays a significant role in postoperative analgesia by effectively reducing pain. However, due to its short half-life, it is challenging for lidocaine achieve the desired duration of clinical settings. Drug delivery systems can regulate release rate over time, making them one most effective strategies achieving sustained release. In this work, multi-level drug system was designed using hyaluronic acid-modified zeolitic imidazolate framework-8 (HA/ZIF-8) nanoparticles and injectable hydrogels composed modified natural polymers. incorporating into ZIF-8 uniformly dispersed within hydrogel network. The dynamic light scattering (DLS) Fourier transform infrared spectrometer (FTIR) results indicate successful loading ZIF-8, while X-ray diffractometer (XRD) confirm that did not disrupt crystal structure ZIF-8. coating acid on enhanced cell biocompatibility, with viability increasing 89% at same concentration. This be injected through 27-guage needle. vitro studies demonstrated more than 4 days kinetic simulations aligned Bshakar model, indicating potential use long-acting analgesic preparations.

Language: Английский

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Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 188 - 188

Published: March 8, 2025

Postoperative adhesions are common complications following surgery, often accompanied by pain and inflammation that significantly diminish patients’ quality of life. Moreover, managing postoperative incurs substantial cost, imposing a considerable financial burden on both patients healthcare systems. Traditional anti-adhesion materials confronted with limitations, such as inadequate tissue adherence in moist environment poor degradability, underscoring the urgent need for more effective solutions. Recently, polysaccharide-based hydrogels have received attention their potential preventing adhesions. The not only facilitate wound healing but also effectively reduce inflammation, providing promising approach to This review provides an extensive analysis progress made development therapy. It highlights principal benefits, outlines future research trajectories, addresses ongoing challenges be overcome.

Language: Английский

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Hydrogel composite scaffold repairs knee cartilage defects: a systematic review

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 10337 - 10364

Published: Jan. 1, 2025

Currently, the incidence of cartilage defects in knee joints owing to different causes is increasing every year, and surgery most common treatment strategy.

Language: Английский

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A Fungistatic Strategy Using a Shear-Thinning pH-Responsive CMCS-OHA-Lp/Lr Hydrogel for Vulvovaginal Candidiasis

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 527 - 527

Published: April 17, 2025

Background: Vulvar vaginal candidiasis (VVC) is a type of vaginitis resulting from Candida infection the mucosa. Traditional treatments using antibiotics often lead to resistance and disrupt microenvironment, causing ongoing problems for patients. In response these challenges, this study introduces multifunctional intelligent responsive probiotic hydrogel designed modulate microecological environment combat albicans infection. Methods: The innovative CMCS-OHA-Lp/Lr was formulated oxidized hyaluronic acid (OHA) carboxymethyl chitosan (CMCS) as carriers, incorporating Lactobacillus plantarum (Lp) rhamnosus (Lr) active components. Comprehensive characterization revealed its chemical structure, rheological properties, rapid self-healing gel degradation, release lactobacilli in vitro. Results: findings demonstrated that hydrogel’s cross-linking conferred significant physical properties. addition, vitro showed cumulative rates Lp Lr medium with pH 5.5 were 83.50 ± 2.70% 73.31 2.22%, which proved pH-responsive characteristics probiotics acidic environments. Furthermore, storage activity indicated survival CMCS-OHA-Lp CMCS-OHA-Lr hydrogels 86.90 0.20% 85.50 0.56%, respectively, proving encapsulation within significantly enhanced stability probiotics. vivo studies further confirmed alleviated vulval edema symptoms reduced C. colonies vagina, thereby mitigating inflammation. Conclusions: conclusion, pH-responsive, self-healing, shear-thinning offers promising approach clinical treatment VVC serves an effective delivery vehicle.

Language: Английский

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Schiff-Base Cross-Linked Hydrogels Based on Properly Synthesized Poly(ether urethane)s as Potential Drug Delivery Vehicles in the Biomedical Field: Design and Characterization

ACS Omega, Journal Year: 2024, Volume and Issue: 9(46), P. 45774 - 45788

Published: Nov. 7, 2024

-forming hydrogels based on the Schiff-base chemistry are promising for drug delivery applications, thanks to their stability under physiological conditions, injectability, self-healing properties, and pH-responsiveness. In this work, two water-soluble poly(ethylene glycol)-based poly(ether urethane)s (PEUs) were engineered. A high-molecular-weight PEU (SHE3350,

Language: Английский

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Enhancing the Stability and Activity of Enzymes through Layer-by-Layer Immobilization with Nanocomposite Hydrogel

Biochemical Engineering Journal, Journal Year: 2024, Volume and Issue: 215, P. 109604 - 109604

Published: Dec. 4, 2024

Language: Английский

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A novel chitosan-Schiff bases bearing a new quinoxaline moiety as an approach for potent antimicrobial agent: Synthesis, characterization and in vitro assessments

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123205 - 123205

Published: Dec. 31, 2024

Language: Английский

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