Advances in the study of polysaccharide-based hydrogel wound dressings

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

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Two-dimensional MXenes for toxin management: Advanced electrocatalytic detection, degradation, and adsorption dynamics

Environmental Chemistry and Ecotoxicology, Journal Year: 2024, Volume and Issue: 6, P. 390 - 407

Published: Jan. 1, 2024

Language: Английский

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MXene-reinforced bioactive polymer hydrogels for biomedical applications

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced

Language: Английский

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Multipurpose triadic MXene/garlic/gellan gum-based architecture in the horizon of bone tissue regeneration

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The use of bioresorbable compositions has been considered a promising therapeutic approach for treating compromised bone tissues. Gellan gum (GG) is predominant polysaccharide recognized its exceptional biocompatibility and biodegradability, facile bio-fabrication, customizable mechanical attributes, rendering it well-suited developing versatile scaffolds. On the other hand, MXene nanosheets have declared representational filler to augment osteogenic effect amend properties polymeric biomaterials. Herein, GG/MXene system was formulated investigate synergistic impact gellan on promoting tissue engineering. Accordingly, Ti3C2Tx nanogalleries were synthesized loaded with 1, 3, 5 wt% ratios into GG matrix fortify overall performances. Based outcomes, containing 1 showed homogeneous surface an optimized topography, providing greater amorphous regions (15%), boosted hydrophilicity (27.5°), favorable Young's modulus (13.43 MPa). Additionally, designed scaffold provided osteogenetic adhesion bactericidal behavior against both Gram-positive (S. aureus) -negative (E. coli) bacteria. To achieve more desirable biological performance, ml garlic extract (GA) introduced freeze-dried composite network. results exhibited better cell attachment in porous GA-mediated furthered antibacterial features through increase zone diameter breakpoint from 4.8 ± 0.2 5.0 0.1 mm 5.9 0.3 6.2 S. aureus E. coli, respectively. Therefore, embedding GA, alongside layered nanomaterials, GG-based could provide convenient scaffolding architecture guided regeneration, facilitating appropriate attachment, growth, proliferation.

Language: Английский

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Multifunctional Bionanocomposite Hydrogels based on Gelatin Methacrylate and Polyphenolic 2D Nanoparticles Decorated with Antimicrobial Bis(imidazolium)-based Ionic Liquids

Composites Science and Technology, Journal Year: 2025, Volume and Issue: 262, P. 111059 - 111059

Published: Jan. 20, 2025

Language: Английский

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MXene-Reinforced Composite Cryogel Scaffold for Neural Tissue Repair

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 479 - 479

Published: Jan. 22, 2025

The development of effective materials for neural tissue repair remains a major challenge in regenerative medicine. In this study, we present novel MXene-reinforced composite cryogel scaffold designed regeneration. MXenes, class two-dimensional with high conductivity and biocompatibility, were integrated into polyvinyl alcohol (PVA) matrix via cryopolymerization to form macroporous, mechanically stable scaffold. morphology, mechanical properties, swelling behavior the different MXene contents have been assessed. effects on viability/proliferation differentiation cells (PC-12) cultured elucidated. MXene/PVA demonstrated excellent cell-supporting potential, not only showing no toxicity but also promoting proliferation PC-12. Additionally, induced neuritogenesis-like process as evidenced by morphological changes enhanced expression marker β-III-tubulin. neuroprotective properties component revealed alleviation oxidative stress reduction intracellular ROS levels. These findings highlight potential MXene-embedded PVA promising material that can be further used conjunction electrostimulation therapy advancing strategies engineering.

Language: Английский

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Biomimetic mineralization of collagen from fish scale to construct a functionally gradient lamellar bone-like structure for guided bone regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136454 - 136454

Published: Oct. 9, 2024

Language: Английский

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