Food Hydrocolloids, Journal Year: 2024, Volume and Issue: unknown, P. 110865 - 110865
Published: Nov. 1, 2024
Language: Английский
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: April 3, 2025
Probiotics play a crucial role in maintaining human health, particularly intestinal health. However, their application has been hindered by issues related to stability, survival through the gastrointestinal tract, and effective delivery target sites. Encapsulating probiotics within liposomes not only protects them from environmental factors such as light, oxygen, temperature but also shields harmful influences like gastric acid bile. In addition, encapsulation promotes growth, release, absorption of intestines. This study reviews characteristics advantages, discusses current state knowledge liposomes. Additionally, investigates how digestive process affects performance probiotics, focusing on structural changes that occur both probiotic-loaded Finally, challenges future directions field liposome-delivered probiotics. Liposome represents an innovative technology significantly enhances stability bioavailability thereby offering improved protection for individuals' novel approach creates new possibilities advantages realm health is anticipated receive broader applications future.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 547 - 547
Published: April 23, 2025
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent, recurrent, and relapsing inflammation of the mucosal layer. Its pathogenesis complex not yet fully understood, with current treatments mainly focused on alleviating symptoms through pharmacological methods. Direct drug administration for UC often leads to poor intestinal bioavailability, suboptimal targeting, an increased risk resistance. Therefore, there urgent need effective delivery systems. Lipid nanoparticles (LNPs) are promising candidates due their high biocompatibility, stability, customizable properties. Oral administration, as preferred treatment approach UC, offers benefits such convenience, cost-effectiveness, better patient compliance. However, oral systems must navigate gastrointestinal tract effectively target colonic lesions, posing significant challenges LNP-based Researchers exploring ways enhance efficiency adjusting LNP composition, surface functionalization, coating. This article reviews recent advancements in research aimed at improving discusses future prospects.
Language: Английский
Citations
0
Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 335077
Published: April 29, 2025
Faecal microbiota transplantation (FMT) has emerged as a transformative therapy for Clostridioides difficile infections and shows promise various GI systemic diseases. However, the poor patient acceptability accessibility of ‘conventional’ FMT, typically administered via colonoscopies or enemas, hinders its widespread clinical adoption, particularly chronic conditions. Oral administration FMT (OralFMT) overcomes these limitations, yet faces distinct challenges, including significant capsule burden, palatability concerns microbial viability during gastric transit. This review provides comprehensive analysis emerging strategies that aim to advance OralFMT by: (1) refining processing technologies (eg, lyophilisation) enable manufacturing low-volume formulations reducing burden (2) developing delivery improve organoleptic safeguard targeted colonic release. These advancements present opportunities expand therapeutic scope, beyond C. infections, towards conditions requiring frequent dosing regimens. While this primarily focuses on optimising delivery, it is important contextualise within broader shift defined consortia. Live biotherapeutic products (LBPs) offer an alternative approach, interplay between LBPs in practice remains unresolved. We postulate continued innovation multidisciplinary approach can further increase efficacy scalability by enabling disease site targeting, co-delivery compounds overcoming colonisation resistance. Realising goals positions cornerstone personalised care across range diseases rooted microbiome health.
Language: Английский
Citations
0
Food Hydrocolloids, Journal Year: 2024, Volume and Issue: unknown, P. 110865 - 110865
Published: Nov. 1, 2024
Language: Английский
Citations
3