Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy DOI Creative Commons
Ying Wang,

Qing Ji,

Chao Yan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly loading capacity chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified their surface can endow immunity-escaping property prolong blood circulation time. More important, neurotransmitter serotonin was encapsulated ZIF-8/DOX oxidative polymerization, which effectively avoid premature leakage DOX in circulation. And formed polyserotonin shell superior photothermal conversion performance, as well adsorption utilized to load imiqumod. When entered tissue, folate molecules specifically bind receptors improve uptake cells. vitro vivo results showed that nanoplatform could generate a large amount heat under near-infrared light irradiation, then induce apoptosis cells, release associated antigens, solve problem heterogeneity. addition, loaded imiquimod immunosuppressive microenvironment, enhance body's anti-tumor immune response, inhibit metastasis recurrence. Therefore, novel designed research achieve controllable release, it is expected become promising new strategy treatment provide corresponding inspiration later development drugs.

Language: Английский

Advances in the study of polysaccharide-based hydrogel wound dressings DOI
Yu Zhang, Ning Qiao, Lihua Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

Citations

1
Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review DOI
Gang Wu,

Chunyan Zhong,

Xiaohui Tian

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442

Published: Jan. 1, 2025

Language: Английский

Citations

0
Research progress of porous drug carriers in tumor diagnosis and therapy DOI
Li Zhu, Xinyuan Li,

Fei Yin

et al.

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Preparation of environmentally responsive PDA&DOX@LAC live drug carrier for synergistic tumor therapy DOI Creative Commons
Lu Liu, Xuefen Zhao

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 10, 2024

Abstract The development of intelligent, environmentally responsive and biocompatible photothermal system holds significant importance for the combined therapy tumors. In this study, inspired by Lactobacillus (LAC), we prepared a biomimetic nanoplatform PDA&DOX@LAC tumor photothermal-chemotherapy integrating chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine (PDA) on surface LAC. not only achieves precise controlled release DOX based slightly acidic microenvironment tissues, but also exhibits enzyme-like properties alleviate hypoxia. Under near-infrared light irradiation, it effectively induces ablation cells, enhances cellular uptake increasing temperature, thus efficiently inhibits cell growth. Moreover, is further confirmed in vivo experiments that cells apoptosis, releases tumor-associated antigens, which engulfed dendritic activate cytotoxic T lymphocytes, thereby suppressing growth prolonging survival period 4T1 tumor-bearing mice. Therefore, immense potential targeting as well provides valuable insights theoretical foundations novel treatment strategies endogenous substances within body.

Language: Английский

Citations

2
Environment-responsive dopamine nanoplatform for tumor synergistic therapy DOI Creative Commons

Chunmin Deng,

Hao Zhang, Song Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 5, 2024

Nanoparticle-based photothermal therapy (PTT) has emerged as a promising approach in tumor treatment due to its high selectivity and low invasiveness. However, the penetration of near-infrared light (NIR) is limited, leading it fails induce damage deep-seated cells within tissue. Additionally, inefficient uptake nanoparticles by results suboptimal outcomes for PTT. In this study, we utilized adhesive properties material, polydopamine (PDA), which can successfully load photosensitizer indocyanine green (ICG) chemotherapeutic drug doxorubicin (DOX) achieve chemotherapy synergy (PDA/DOX&ICG), aiming compensate defects single treatment. To extending blood circulation time PDA/DOX&ICG nanoparticles, evading clearance body immune system achieving targeted delivery tissues, protective envelopment was created using erythrocyte membranes modified with folate acid (FA-EM). After reaching tissue, obtained FA-EM@PDA/DOX&ICG specific bind receptors on surface cells, improve behavior release loaded DOX ICG response unique microenvironment. ICG, typical photosensitizer, significantly enhances conversion performance thus inducing damage. vitro vivo experimental demonstrated that coordinated NIR not only effectively inhibits growth, but also exhibits superior biocompatibility, mitigating DOX-induced tissue

Language: Английский

Citations

1
Research progress on the ‘all-in-one’ photothermal platform prepared based on polydopamine for tumor synergy therapy DOI
Li Wang, Lei Zhang

Polymer Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Language: Английский

Citations

1
Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy DOI
Ying Wang,

Qing Ji,

Chao Yan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting treatment. In this study, an environment-responsive therapeutic nanoplatform based on metal-organic frameworks (FM@IQ/PST&ZIF-8/DOX) is developed. Under near-infrared (NIR) irradiation, it realizes combined treatment photothermal/immunotherapy/chemotherapy, compensating for deficiencies each single effectively achieving cascade effect When enters blood circulation, surface-modified erythrocyte cell membrane can disguise itself, avoiding its elimination body immune system. Moreover, folic acid molecules specific binding with receptors surface cells, increasing uptake to them thereby promoting accumulation in tissues. NIR induces apoptosis releases tumor-associated antigen, solving problem poor caused heterogeneity. Subsequently, slightly acidic cause framework FM@IQ/PST&ZIF-8/DOX collapse, release imiquimod doxorubicin. platform, imiquimod, as a small molecule modulator, improve immunosuppressive microenvironment, stimulate body's anti-tumor response inhibit recurrence metastasis tumors. Therefore, novel drug delivery system designed research not only achieve controllable release, but also microenvironment. It expected become promising new strategy provide corresponding inspiration later development drugs.

Language: Английский

Citations

0
Fe-coordinated carbon dots with single atom nanozyme catalytic activity for synergistic catalytic/chemo-therapy in breast cancer DOI
Mengke Lu,

Jianxia Ding,

Yupeng Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137776 - 137776

Published: Nov. 1, 2024

Language: Английский

Citations

0
A review of carbohydrate polymer-synthesized nanoparticles in cancer immunotherapy: Past, present and future perspectives DOI
Chunyan Wang, Xueyao Zhang,

Qiaobei Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138195 - 138195

Published: Dec. 5, 2024

Language: Английский

Citations

0
Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy DOI Creative Commons
Ying Wang,

Qing Ji,

Chao Yan

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly loading capacity chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified their surface can endow immunity-escaping property prolong blood circulation time. More important, neurotransmitter serotonin was encapsulated ZIF-8/DOX oxidative polymerization, which effectively avoid premature leakage DOX in circulation. And formed polyserotonin shell superior photothermal conversion performance, as well adsorption utilized to load imiqumod. When entered tissue, folate molecules specifically bind receptors improve uptake cells. vitro vivo results showed that nanoplatform could generate a large amount heat under near-infrared light irradiation, then induce apoptosis cells, release associated antigens, solve problem heterogeneity. addition, loaded imiquimod immunosuppressive microenvironment, enhance body's anti-tumor immune response, inhibit metastasis recurrence. Therefore, novel designed research achieve controllable release, it is expected become promising new strategy treatment provide corresponding inspiration later development drugs.

Language: Английский

Citations

0