Foods,
Journal Year:
2024,
Volume and Issue:
13(22), P. 3552 - 3552
Published: Nov. 7, 2024
In
recent
years,
research
on
active
polysaccharides
has
progressed
significantly,
particularly
regarding
their
anticancer
and
immunomodulatory
properties.
Among
these,
clam
polysaccharides,
a
type
of
marine-derived
polysaccharide,
exhibit
notable
biological
activities,
including
both
effects
immune
modulation.
The
aims
this
study
are
to
investigate
the
microwave-extracted
polysaccharide
(MCP)
in
vitro.
Cell
experiments
demonstrated
that
MCP
significantly
inhibited
colony
formation
migration
HT-29
cells.
Furthermore,
treatment
with
led
downregulation
Bcl-2
gene
expression,
reduction
mitochondrial
membrane
potential,
activation
cytochrome
C
caspase-3
gene,
and,
finally,
induction
apoptosis
cells,
implying
involvement
pathway.
Additionally,
was
found
prompt
phenotypic
shift
macrophages
from
M2
M1
subtype
M0
subtype.
also
decreased
reactive
oxygen
species
(ROS)
levels
within
cancer
thereby
augmenting
efficacy
through
dual
mechanism
antioxidant
enhancement.
These
findings
suggest
MCPs
present
significant
potential
as
natural
antitumor
agents
immunomodulators,
especially
development
functional
foods
or
drugs.
