Chemical Papers, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 13, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140508 - 140508
Published: Jan. 1, 2025
Language: Английский
Citations
3
Polymer Composites, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract In this study, 3D printing technology is used to develop nanocomposite scaffolds based on polylactic acid (PLA) and hydroxyapatite (HA). PLA was functionalized with itaconic anhydride (PLA f ) via radical grafting improve affinity the inorganic nanofiller accelerate hydrolytic degradation. Fourier‐transform infrared (FTIR) Nuclear Magnetic Resonance (NMR) spectroscopies confirmed occurrence of chemical functionalization. Preliminary characterization films PLA, relative nanocomposites through water contact angle measurements highlighted an increase wettability for , due hydrophilic groups grafted onto polymer chain. Thermal analysis showed glass transition temperature ( T g in nanocomposites, likely enhanced matrix‐nanoparticle interactions. Scanning electron microscopy (SEM) revealed more defined homogeneous fibers ‐HA5 ‐HA10, meanwhile results from compression tests indicated improved processability mechanical properties ‐based scaffolds, as evidenced by increased values Young modulus. Hydrolytic degradation studies Phosphate Buffered Saline (PBS) solution greater weight loss molecular decrease ‐HA5, suggesting faster hydrophilicity. Biological human Mesenchymal Stem Cells (hMSCs) demonstrated that all promoted cell proliferation, ‐HA formulations showing higher effect cellular behavior terms growth alkaline phosphatase (ALP) levels, indicating functionalization improves attachment, proliferation early osteogenic differentiation. Highlights Functionalization enhances hydrophilicity HA affinity. Nanocomposite are successfully developed printing. ink printability, making uniform structures. exhibit accelerated support adhesion
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138772 - 138772
Published: Dec. 1, 2024
Language: Английский
Citations
7
Materials & Design, Journal Year: 2024, Volume and Issue: 244, P. 113145 - 113145
Published: July 8, 2024
The repair of secondary critical bone defects is an international medical challenge. Bone tissue engineering provides methods and technology for repair. regeneration mechanism serves as inspiration the material structural design scaffolds. In terms materials, this review draws from biological characteristics host cells in osteogenic microenvironment (including osteoblast lineage, vascular cell inflammatory cells, etc.), reviewing regulatory mechanisms self-healing proposing autonomous living materials scaffolds which prepared by in-situ manufacturing. Autonomous regulate migration, proliferation differentiation real time releasing steadily long-term. Regarding structure, we functional role natural structures homeostasis, providing insights into bone-inspired Due to conflict between mechanical properties ability, proposes assembled They can prolong half-life provide support attachment points new growth, autonomously microenvironment. have potential advance research progress field pave way novel clinical treatments.
Language: Английский
Citations
4
Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 20, 2024
The extensive utilization of natural polymers in tissue engineering is attributed to their excellent biocompatibility, degradability, and resemblance the extracellular matrix. These have a wide range applications such as delivering therapeutic medicine, detecting diseases, sensing biological substances, promoting regeneration, treating diseases. This brief review current developments properties uses widely used biomedical derived from nature. Additionally, it explores correlation between characteristics functions these materials different highlights prospective direction for advancement polymer engineering.
Language: Английский
Citations
4
Journal of Manufacturing and Materials Processing, Journal Year: 2025, Volume and Issue: 9(4), P. 129 - 129
Published: April 14, 2025
Three-dimensional (3D) bioprinting using biocompatible polymers has emerged as a revolutionary technique in tissue engineering and regenerative medicine. These biopolymers mimic the extracellular matrix (ECM) enhance cellular behavior. The current review presents recent advancements additive manufacturing processes including Stereolithography (SLA), Fused Filament Fabrication (FFF), Selective Laser Sintering (SLS), inkjet printing. It also explores fundamentals of 3D printing properties for bioprinting. By mixing biopolymers, enhancing rheological characteristics, adding bioactive components, further have been made organ transplantation, drug development, engineering. As research progresses, potential to fundamentally transform healthcare system is becoming obvious clear. However, therapeutic printed structures hindered by issues such material anisotropy, poor mechanical properties, need more biodegradable architectures. Future should concentrate on optimizing process sophisticated computational techniques, systematically examining characteristics customizing bioinks different cell types, exploring sustainable materials.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 514, P. 163129 - 163129
Published: April 28, 2025
Language: Английский
Citations
0
Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: May 24, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134752 - 134752
Published: Aug. 30, 2024
Language: Английский
Citations
3
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189
Published: Aug. 29, 2024
With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as
Language: Английский
Citations
1