Formulation and Evaluation of Licorice-Extract-Enhanced Chitosan, PVA, and Gelatin-Derived Hydrogels for Wound Dressing
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(5), P. 439 - 439
Published: April 23, 2025
Wound
infections
remain
a
significant
clinical
challenge,
impeding
healing
and
causing
deterioration.
Recently,
multifunctional
hydrogel
dressings
have
gained
interest
as
an
effective
treatment
to
treat
efficiently
enhance
wound
recovery.
The
present
research
is
focused
on
the
development
of
composite
hydrogels
comprising
chitosan
(CS),
polyvinyl
alcohol
(PVA),
gelatin
(GEL)
licorice
extract
(LE),
using
freeze
gelation
technique.
resulting
CS/PVA/GEL
incorporating
LE
were
characterized
by
FTIR,
XRD
SEM.
FTIR
analysis
confirmed
presence
specific
functional
groups
within
molecules.
exhibited
amorphous
nature
hydrogels.
SEM
revealed
that
increasing
CS
ratio
in
created
more
porous
structure
with
smaller
pore
size.
All
demonstrated
oxygen
permeability,
which
crucial
for
process.
Among
synthesized
hydrogels,
MM-2
containing
PVA
(20
mL)
(4
superior
performance
water
retention
capacity
440%
moisture
content
91%.
This
exceptional
result
can
be
attributed
higher
proportion
material’s
structure,
enhances
its
hydrophilic
properties.
showed
good
antibacterial
potential
against
three
selected
strains
bacteria
including
Bacillus
subtilis
(B.
subtilis),
Staphylococcus
aureus
(S.
aureus)
Escherichia
coli
(E.
coli).
hydrogels’
cytotoxicity
levels
assessed
through
hemolysis
assay
results
all
non-toxic.
hydrolytic
breakdown
interconnected
components
slow
degradation,
making
them
appropriate
long-term
treatment.
Specifically,
MM-4
74%
degradation
rate
displayed
75%
antioxidant
activity,
indicating
effectiveness
chronic
applications.
These
characteristics
CS/PVA/GEL/LE-derived
suggest
their
use
promising
candidate
care
Language: Английский
Study on Fabrication and Properties of Polyvinyl Alcohol/Chitosan Nanofibers Created from Aqueous Solution with Acetic Acid and Ethanol by the Electrospinning Method
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3393 - 3393
Published: Nov. 30, 2024
The
development
of
nanofibers
with
incorporated
biologically
active
molecules
a
targeted
mode
action
is
current
research
trend.
Potential
materials
for
the
such
systems
include
poly(vinyl
alcohol)
(PVA)
and
chitosan
(CS)
nanofibers,
which
are
traditionally
fabricated
by
electrospinning
aqueous
solutions
these
polymers
acetic
acid.
To
improve
drug
integration,
ethanol
was
added
to
binary-solvent
system.
This
results
in
several
important
data:
noticeable
shifts
solvent
system’s
solubility
parameter,
interaction
various
component
forces,
optical
rheological
properties
PVA-CS
solution.
use
electrospun
solution
also
contributes
adjusting
parameters
Teas
graph,
maintaining
“fh
−
fd”
optimal
region
fabrication
nanofibers.
Increasing
efficiency
nanofiber
quite
difficult
due
requirements
parameters,
technological
environmental
parameters;
however,
this
increased
work
2
3
times
more
morphology.
These
demonstrate
that
containing
4%
PVA,
3%
CS,
15%
ethanol,
45%
acid
increasing
productivity,
improving
morphology
diameter
without
changing
chemical
bonds.
XRD
spectrum
revealed
alterations
crystal
lattice
led
variation
their
thermal
tensile
properties.
Language: Английский