Nanocarriers and their Integrated Microneedle Systems-Mediated Drug Delivery for the Treatment of Moderate-Severe Dermatological Diseases: Recent Progress, Applications and Future Perspectives
Journal of Drug Delivery Science and Technology,
Journal Year:
2025,
Volume and Issue:
106, P. 106748 - 106748
Published: Feb. 22, 2025
Language: Английский
Mirtazapine loaded NLCs based Hydrogel for Topical Delivery in Pruritis: Statistical Optimization, In Vitro & Skin Irritation Evaluation
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 18
Published: April 22, 2025
Systemic
mirtazapine
(MRT)
delivery
for
the
treatment
of
pruritis
exhibits
severe
side
effects
which
needs
to
be
addressed.
For
this
purpose,
topical
nanostructured
lipid
carriers
(NLCs)
containing
MRT
were
developed
minimize
and
enhance
therapeutic
efficacy.
The
microemulsion
method
was
utilized
preparation
loaded
NLCs
final
optimized
formulation
in
gel
effective
application.
terms
particle
size
(PS),
zeta
potential
(ZP),
polydispersity
index
(PDI),
percentage
entrapment
efficiency
(%
EE)
by
keeping
view
quantity
drug,
tween
80
lipids
ratio.
Optimized
nano
exhibited
a
PS
186.3
±
1.2
nm,
with
0.217
0.03
PDI,
ZP
-26.0
0.2
mV
%EE
86.3
0.3%.
Fourier
transform
infrared
spectroscopy
(FTIR)
differential
scanning
calorimetry
(DSC)
analysis
confirmed
compatibility
components
encapsulation
drug
inside
matrix
respectively.
Further,
gel-based
dispersion
analyzed
rheology
textural
characterization.
prepared
hydrogel
(MRT
gel)
had
transparent
appearance,
non-gritty
texture,
pH,
spreadability
322.33
0.25%
release
81%
24
hours
followed
Korsmeyer-
Peppas
model.
Ex
vivo
skin
permeation
depicted
only
6.20
µg/cm2
across
after
hours.
Skin
irritation
study
showed
no
signs
erythema
edema
treated
group.
formulated
successfully
may
used
as
promising
vehicle
pruritus.
Language: Английский
Emerging Treatments and New Vehicle Formulations for Atopic Dermatitis
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1425 - 1425
Published: Nov. 7, 2024
Atopic
dermatitis
is
one
of
the
most
common
inflammatory
skin
diseases,
with
an
increasing
incidence
among
both
children
and
adults.
The
recurrent
nature,
often
persistence
symptoms,
polymorphism
response
to
current
therapies
have
led
increased
research
in
therapeutic
area
dedicated
this
condition.
understanding
pathophysiological
pathways
has
contributed
development
innovative
therapies,
including
biological
JAK
inhibitors,
but
also
emerging
technologies
like
nanotechnology-based
drug
delivery
systems.
These
innovations
promise
enhanced
efficacy,
reduced
side
effects,
improved
patient
outcomes.
ongoing
exploration
novel
vehicles,
formulations,
natural
biopolymers,
along
cutting-edge
agents
tapinarof
mesenchymal
stem
cells,
highlights
potential
for
even
more
precise
personalized
management
AD
future.
Despite
these
advances,
challenges
persist,
particularly
ensuring
long-term
safety,
accessibility,
broader
application
necessitating
continued
development.
Language: Английский
Nanoparticles composed of polysaccharide chitosan and oligosaccharide alginate for strengthen transdermal delivery of tacrolimus in atopic dermatitis
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100655 - 100655
Published: Dec. 1, 2024
Language: Английский