Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities DOI Creative Commons

Liucan Wang,

Guoqing Chen, Yang Yang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9889 - 9904

Published: Nov. 1, 2024

Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression inflammatory bowel disease (IBD) and presents potential therapeutic target. Anti-oxidant therapy, aimed at mitigating ROS, emerging as cornerstone IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise inhibiting inflammation through ROS scavenging, enhancing efficacy. Recent focus scavenging has centered on metal oxide nanoenzymes polyphenol-based nanomaterials. The primary challenges are catalytic efficiency functional integration these nanomaterials agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent unique catechol groups that interact biomolecules such proteins nucleic acids. strong ion chelating ability catechols enriches structure functionality nanomaterials, improving physicochemical nanocarriers enabling innovative designs multifunctional drug delivery systems (DDSs). Research DDSs expanded include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, polydopamine. These anti-oxidants, which incorporate polyphenols, demonstrated novel reduce essential components carriers. This review focuses design application for treatment, offering comprehensive discussion use polyphenols posed diverse roles strategies, including impact physical chemical DDSs.

Language: Английский

Flavonoids as Natural Anti-Inflammatory Agents in the Atopic Dermatitis Treatment DOI Creative Commons
Nik Khairunissa Nik Abdullah Zawawi, Haslina Ahmad,

Rajesh Madatheri

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 261 - 261

Published: Feb. 15, 2025

Eczema is a complex autoimmune condition characterised mainly by inflammation and skin lesions along with physical psychological comorbidities. Although there have been significant advances in understanding the mechanisms behind atopic dermatitis, conventionally available treatments yield inconsistent results some unintended consequences. In today's digital age, where knowledge just click away, natural-based supplements on rise for more "natural" treatment towards any type of disease. Natural compounds, particularly derived from medicinal plants, piqued interest development herbal remedies chronic inflammatory conditions. Among many flavonoids shown promise treating eczema due to their strong anti-inflammatory, antioxidant, anti-allergic properties, making them helpful preventing allergic reactions, inflammation, irritation. This review highlights therapeutic potential flavonoid-based bioactive compounds manage eczema, emphasising action. Additionally, providing comprehensive analysis emerging established while bridging gap between traditional modern medicine. Flavonoids offer variety opportunities further research innovative formulations that can maximise its full benefits. Further combination various approaches such as nanoencapsulation enhanced bioavailability, hydrogel-based delivery systems controlled release, additive manufacturing personalised topical formulations, could align future precision medicine needs.

Language: Английский

Citations

1
Anti-inflammatory Potential of Plants of Genus Rhus: Decrease in Inflammatory Mediators In Vitro and In Vivo – a Systematic Review DOI Creative Commons
Alejandra Jazmín Rodríguez-Castillo, César Pacheco‐Tena, Rubén Cuevas-Martínez

et al.

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Plants from the Rhus genus are renowned for their medicinal properties, including anti-inflammatory effects; however, mechanisms underlying these effects remain poorly understood. This systematic review, conducted following PRISMA guidelines, evaluated of plants and explored potential pharmacological mechanisms. A total 35 articles were included, with majority demonstrating a low-risk bias, as assessed using SYRCLE tool. verniciflua, chinensis, coriaria, succedanea, tripartite, crenata, trilobata analyzed in reviewed articles. In vitro studies consistently demonstrated ability to reduce key inflammatory mediators such TNF-α, IL-1β, IL-6. vivo confirmed murine models inflammation, doses mostly 400 800 mg/kg body weight, no reports toxicity. Fifty-four distinct vivo; pattern was identified that could elucidate action acute or chronic inflammation. The clinical trial reported humans at 1000 6 weeks. review data on Rhus-mediated reduction integrated visualized Reactome bioinformatics database, which suggested mechanism involves inhibition inflammasome signaling. These findings support basis developing therapies. Further research is needed optimize dosage regimens fully explore applications.

Language: Английский

Citations

0
Tannic Acid as an Ion Channel Modulator: An Understanding of Its Pharmacological Spectrum DOI

King‐Chuen Wu,

C. Justin Lee, Paul Chan

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(3)

Published: May 1, 2025

ABSTRACT Tannic acid (TA) is a polyphenol present in many plant foods and beverages such as green tea wines. As food additive, it has been recognized by Food Drug Administration generally safe. candidate drug, its pharmacological effects cover wide spectrum, ranging from antibacterial, anticancer, cardioprotection to neuroprotection. TA shown modulate number of ion channels Ca 2+ ‐activated Cl − (CaCC), voltage‐gated K + (Kv) transient receptor potential (TRP) channels, producing analgesia, antihypertensive reduction airway hypersensitivity. In this review we focus on how channel modulation may account for the various cells organ systems. Further emphasis should be paid factors, dosage routes administration, before actions could translated into therapeutic applications.

Language: Английский

Citations

0
Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity DOI Creative Commons

Xueshuang Lai,

Shuang Liu, Jian Miao

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 30, 2024

Language: Английский

Citations

3
Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities DOI Creative Commons

Liucan Wang,

Guoqing Chen, Yang Yang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9889 - 9904

Published: Nov. 1, 2024

Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression inflammatory bowel disease (IBD) and presents potential therapeutic target. Anti-oxidant therapy, aimed at mitigating ROS, emerging as cornerstone IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise inhibiting inflammation through ROS scavenging, enhancing efficacy. Recent focus scavenging has centered on metal oxide nanoenzymes polyphenol-based nanomaterials. The primary challenges are catalytic efficiency functional integration these nanomaterials agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent unique catechol groups that interact biomolecules such proteins nucleic acids. strong ion chelating ability catechols enriches structure functionality nanomaterials, improving physicochemical nanocarriers enabling innovative designs multifunctional drug delivery systems (DDSs). Research DDSs expanded include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, polydopamine. These anti-oxidants, which incorporate polyphenols, demonstrated novel reduce essential components carriers. This review focuses design application for treatment, offering comprehensive discussion use polyphenols posed diverse roles strategies, including impact physical chemical DDSs.

Language: Английский

Citations

1