Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Effects of starch filling on physicochemical properties, functional activities, and release characteristics of PBAT-based biodegradable active films loaded with tea polyphenols DOI
Xiaosong Zhai,

Jinhong Han,

Liang Chang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134505 - 134505

Published: Aug. 5, 2024

Language: Английский

Citations

9
Characterization and environmental footprint of crosslinked faba bean starch-based ecofilms reinforced with tunicate cellulose nanocrystals DOI Creative Commons
Kehinde James Falua,

Amin Babaei‐Ghazvini,

Bishnu Acharya

et al.

Sustainable materials and technologies, Journal Year: 2025, Volume and Issue: 43, P. e01236 - e01236

Published: Jan. 10, 2025

Language: Английский

Citations

1
Advances in the study of polysaccharide-based hydrogel wound dressings DOI
Yu Zhang, Ning Qiao, Lihua Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

Citations

1
Bioactivity and biomedical applications of pomegranate peel extract: a comprehensive review DOI Creative Commons
Jinsong Du,

H. Wang,

Lingyun Zhong

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Pomegranate peel is a by-product generated during the processing of pomegranate ( Punica granatum L.) fruit, accounting for approximately 50% total mass fruit. Although usually regarded as waste, it rich in various bioactive metabolites such polyphenols, tannins, and flavonoids, demonstrating significant medicinal nutritional value. In recent years, extract (PPE) has shown broad application prospects biomedical field due to its multiple effects, including antioxidant, anti-inflammatory, antibacterial, anti-apoptotic properties, promotion cell regeneration. This review consolidates major PPE explores applications materials, nanodrug carriers, hydrogels, tissue engineering scaffolds. By synthesizing existing literature, we delve into potential value biomedicine, challenges currently encountered, future directions research. The aim this provide scientific basis optimizing utilization facilitate broader field.

Language: Английский

Citations

0
Leveraging citrus extract to enhance antioxidant properties of mung bean (Vigna radiata) protein edible films DOI
R. Selvaraj, K. Arunprasath,

P. Karuppiah

et al.

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Halloysite nanotubes potentiate protein assembly for facile fabrication of nanocomposite thin film and its application in wound dressing DOI
Jiaxin Zhang, Zhen Huang,

Minghui Yang

et al.

Applied Clay Science, Journal Year: 2025, Volume and Issue: 272, P. 107816 - 107816

Published: April 11, 2025

Language: Английский

Citations

0
Multiparticulate Drug Delivery of Losartan Potassium via Extrusion-Spheronization: Formulation and Dissolution Comparisons DOI Creative Commons
Vishal Yadav,

D. S. Salunkhe,

Vasant Y. Lokhande

et al.

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Background: Losartan potassium, an antihypertensive medication, has high solubility and a short half-life that result in potential adverse effects rapid drug clearance. Multiparticulate delivery systems enhance the drug’s bioavailability, decrease patient-to-patient variability, optimize distribution. Herein, losartan potassium pellets for sustained release were developed characterized. Methods: The formulation process involved varying concentrations of Eudragit RSPO (200 mg, 400 or 600 mg) L100 across nine pellet batches, adjusting triethyl citrate accordingly. pellets’ bulk density, tapped flow properties (Carr’s index, Hausner’s ratio, angle repose), content, particle size distribution, vitro evaluated. Interactions between excipients analyzed with FTIR DSC. Results: spectra indicated physical interactions without major chemical alterations, whereas DSC thermograms revealed changes thermal behavior due to excipient interactions. In studies formulations higher achieved controlled, prolonged release. optimized batch (F7) demonstrated balanced characteristics including favorable good properties, profile. Varying polymer plasticizer significantly influenced performance, F7 was found be most promising sustained-release applications. Conclusion: This study underscores importance selection optimization developing effective systems, implications enhancing therapeutic outcomes clinical practice.

Language: Английский

Citations

1
Engineering Ga-doped mesoporous bioactive glass-integrated PEEK implants for immunomodulatory and enhanced osseointegration effects DOI Creative Commons

Shiran Zhou,

Zubo Tu,

Zhigang Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114189 - 114189

Published: Aug. 29, 2024

With the increasing aging population, demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) considered a promising material due to its excellent biocompatibility. However, lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it urgent bio-functionalize PEEK-based promote This study employs simple, economical, feasible method coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing multifunctional implant. The resulting bio-functionalized macrophage M2 phenotype polarization, thus fostering an anti-inflammatory microenvironment. Moreover, direct osteogenic effect Ga ions immuno-osteogenic through promoting polarization enhance differentiation potential in vitro integration vivo. A sequence vivo experiments substantiates essential intricate function this innovative implants. regulating normal immunity metabolism. Overall, application Ga-MBGs provides effective developing surface implant, capable modulating metabolism, holds significant clinical as

Language: Английский

Citations

0