Targeting ferroptosis reveals a new strategy for breast cancer treatment: a bibliometric study DOI Creative Commons
Junlin Liu, Rong Tang, Jie Zheng

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 19, 2024

Studies exploring the role of ferroptosis in pathogenesis breast cancer have proliferated over past decade, especially 2023, with a staggering 217 publications related studies. However, there are still significant gaps comprehensive scientometric analysis and mapping scientific studies, terms temporal study area tracking, principal investigators, emergence new hotspots. This aims to summarize development latest research results on ferroptosis-targeted treatment use bibliometric methods draw visual map explore future trends. On May 11, 2024, this updated progress 11 years by retrieving data from January 1, 2014, Web Science database. In research, many software including VOSviewer, chorddiag R Language Pack, Scimago Graphica, Citespace 6.3.R1, Cluster Profiler, enrichplot, ggplot2 Cytoscape, STRING online platform used make in-depth visualization measurement results. Statistical these showed that China accounted for 74.43% total publications, highlighting China's dominant relationship between cancer. Several institutions, Sun Yat-sen University, Zhejiang Shanghai Jiao Tong achieved impressive Efferth, Thomas is most prominent author field has highest number subfield oncology. clearly shows plays crucial triple-negative cancer, hepatocellular carcinoma, glioma, leukemia, mitochondrial disease, lymphoma, bladder tumors, lung adenocarcinoma, esophageal tumors. provides evaluation deepens our understanding current status targeting treating Thus, it helps researchers fields directions comprehensively extracting important information

Language: Английский

Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review DOI
Xiao‐fei Liu, Liufang Huang,

Xuewu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140221 - 140221

Published: Jan. 22, 2025

Language: Английский

Citations

6
Alleviation of sepsis-induced lung and liver injury by polysaccharides from Tetrastigma hemsleyanum Diels et Gilg via suppression of TLR4/NF-κB/COX-2 pathway and modulation of immune checkpoint molecules DOI

Mengjia Zhao,

Senmiao Chen,

Jingwen Xu

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 179, P. 52 - 64

Published: Feb. 7, 2025

Language: Английский

Citations

1
Structural characterization and immunomodulatory activity analysis of a novel pectic polysaccharide extracted from Tetrastigma hemsleyanum Diels et Gilg and its hydrolysis products DOI
Shasha Tian,

Zian Mao,

Yuexia Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123502 - 123502

Published: March 13, 2025

Language: Английский

Citations

1
The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer DOI Open Access
Omowumi Oyeronke Adewale, Patrycja Wińska, Adrianna Maria Piasek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12202 - 12202

Published: Nov. 13, 2024

Breast cancer is the most common affecting women worldwide. The associated morbidity and mortality have been on increase while available therapies for its treatment not totally effective. treatment, chemotherapy, sometimes has dangerous side effects because of non-specific targeting, in addition to poor therapeutic indices, high dose requirements. Consequently, agents with anticancer are being sought that can reduce induced by chemotherapy increasing cytotoxicity cells. This possible using natural compounds safe biologically active. There many reports plant polysaccharides due their bioactive properties. use polysaccharide together a conventional cytotoxic drug may offer wide benefits therapy, producing synergistic effects, thereby reducing and, so, effects. In this review, we highlight an overview chemotherapeutic drugs breast preclinical studies, including mechanisms activities. findings emphasize potential improve outcomes cancer, paving way more effective safer strategies.

Language: Английский

Citations

4
Puerarin triggers sensitivity to ferroptosis in glioblastoma cells by activating SIRT3/NCOA4-dependent autophagy DOI
Peng Lv,

Yueyun Hu,

Lei Ding

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114246 - 114246

Published: Feb. 9, 2025

Language: Английский

Citations

0
Iron-Dependent Cell Death: Exploring Ferroptosis as a Unique Target in Triple-Negative Breast Cancer Management DOI Creative Commons

L. Tan,

Jiaxing Liu, C Ma

et al.

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.

Language: Английский

Citations

0
Exploring Tetrastigma hemsleyanum polysaccharides: A recent advance in preparation, structural features, bioactivities, and potential application prospects DOI
Lihao Wang, Qian Wang,

Chenqing Dong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143477 - 143477

Published: April 1, 2025

Language: Английский

Citations

0
Targeting ferroptosis reveals a new strategy for breast cancer treatment: a bibliometric study DOI Creative Commons
Junlin Liu, Rong Tang, Jie Zheng

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 19, 2024

Studies exploring the role of ferroptosis in pathogenesis breast cancer have proliferated over past decade, especially 2023, with a staggering 217 publications related studies. However, there are still significant gaps comprehensive scientometric analysis and mapping scientific studies, terms temporal study area tracking, principal investigators, emergence new hotspots. This aims to summarize development latest research results on ferroptosis-targeted treatment use bibliometric methods draw visual map explore future trends. On May 11, 2024, this updated progress 11 years by retrieving data from January 1, 2014, Web Science database. In research, many software including VOSviewer, chorddiag R Language Pack, Scimago Graphica, Citespace 6.3.R1, Cluster Profiler, enrichplot, ggplot2 Cytoscape, STRING online platform used make in-depth visualization measurement results. Statistical these showed that China accounted for 74.43% total publications, highlighting China's dominant relationship between cancer. Several institutions, Sun Yat-sen University, Zhejiang Shanghai Jiao Tong achieved impressive Efferth, Thomas is most prominent author field has highest number subfield oncology. clearly shows plays crucial triple-negative cancer, hepatocellular carcinoma, glioma, leukemia, mitochondrial disease, lymphoma, bladder tumors, lung adenocarcinoma, esophageal tumors. provides evaluation deepens our understanding current status targeting treating Thus, it helps researchers fields directions comprehensively extracting important information

Language: Английский

Citations

0