Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status DOI Creative Commons

Qianbo Song,

Junju Zou,

Sau Wan Cheng

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 6, 2024

ABSTRACT Dendrobium officinale is a kind of popular functional food to be consumed by both healthy and diabetic people. As its major constituent, D. polysaccharide (DOP) mainly utilized gut microbiota. Despite distinctive microbiota composition between individuals, no study compared the interplay DOP under status. The current aims investigate compare metabolic signatures regulatory potential on Our serial in vitro fermentation investigations found that mannose was more status with higher production propanoic acid lower butyric those Moreover, metabolomic analyses revealed different impacts intestinal microbial metabolites upregulating taurine downregulating 2‐hydroxybutyric only occurring Biodiversity demonstrated treatment could significantly improve diversity while there significant effect Further indicated promote probiotics ( Dubosiella , Bifidobacterium Akkermansia ) inhibit pathogens Escherichia‐Shigella In summary, our insights into effects provided scientific evidence for broad use as food.

Language: Английский

Identification of the Pharmacological Components and Its Targets of Sanghuang by Integration of Nontarget Metabolomics and Network Pharmacology Analysis DOI Open Access
Hengqian Lu, Jingtao Zhang, Yongzhong Wang

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 2, 2025

The objective of this study is to comprehensively identify the core pharmacological components and their respective targets three medicinal fungi Sanghuangs including Sanghuangporus vaninii (SV), lonicericola (SL), Inonotus hispidus (IH). Metabolomics analysis indicated that a total 495 660 differential metabolites were obtained in mycelium fermentation broth samples among Sanghuangs, respectively. network pharmacology showed 6-[1]-ladderane hexanol, R-nostrenol, candidone, ellagic acid, quercetin overlapping active ingredients Sanghuang species for diabetes mellitus, immune system disease, neoplasm. Certonardosterol A, dalamid, ethylene brassylate are unique SV, certonardosterol K, kaempferide, esculetin SL. Asbestinine, neoandrographolide, isosakuranetin, daucosterin IH. Accordingly, common ESR1, PIK3CA, LYN. PRKCA, EGFR, STAT3 SL, IH, primary targets, addition component-target interaction have been identified present study, provide foundation future research on prevention treatment disease using Sanghuangs.

Language: Английский

Citations

1
Structure characterization of polysaccharide isolated from Ribes nigrum L. and it's bioactivity against gout DOI
Xianjun Huang,

Sitao Zheng,

Yujia Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141359 - 141359

Published: Feb. 1, 2025

Language: Английский

Citations

1
Activity-oriented isolation of nine α‑glucosidase inhibitors from the Rheum tanguticum waste and interaction mechanism analysis DOI Creative Commons

Weihang Lu,

Tao Chen, Cheng Shen

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 226, P. 120697 - 120697

Published: Feb. 20, 2025

Language: Английский

Citations

0
Identification of Dendrobium officinale species and authentication of commercial products by DNA barcoding and high-resolution melting analysis DOI
Zhilong He, Yang Zhao,

Cui Dong

et al.

Journal of Applied Research on Medicinal and Aromatic Plants, Journal Year: 2025, Volume and Issue: unknown, P. 100633 - 100633

Published: March 1, 2025

Language: Английский

Citations

0
The role of molecular weight on chitosan and chitosan oligosaccharides in sleep regulation: Integrating network pharmacology and multi-omics analysis in Drosophila DOI

Yuxuan Liang,

Kaiyu Jiang, Zhengqi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142147 - 142147

Published: March 1, 2025

Language: Английский

Citations

0
Characterizations of the structure and properties of exopolysaccharide from Leuconostoc citreum SFL-2-8 and its potential for use in food coating preservation DOI
Wenjie Yang, Liping Liu, Xiangying Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142150 - 142150

Published: March 1, 2025

Language: Английский

Citations

0
Preparation Process Optimization of Glycolipids from Dendrobium officinale and the Difference in Antioxidant Effects Compared with Ascorbic Acid DOI Open Access
Long Yan,

Jiajing Yang,

Hongfei Ji

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3664 - 3664

Published: Oct. 28, 2024

Background:Dendrobium officinale glycolipids (DOG), often left as residues after hot water extraction for polysaccharide production, are discarded. Methods: This study investigates the optimal of DOG using response surface methodology, focusing on liquid–solid ratios, ethanol concentrations, temperatures, and times, while preliminarily analyzing DOG’s structural properties. Additionally, differences in antioxidant effects between ascorbic acid based intestinal flora metabolism were further evaluated. Results: The parameters determined follows: ratio 20 mL/g, concentration 70%, temperature 70 °C, time 2.5 h, yielding 2.64 ± 0.18%. In addition, was identified a diglyceride, mainly composed glucose, mannose, linoleic acid, 9,12,15-octadecatrienoic presented certain direct free radicals scavenging effects. animal experiments, unlike increased Bacteroides acidifaciens abundance mice, up-regulated piceatannol expression, down-regulated 1-naphthol which contributed to by enhancing activities SOD GSH-Px reducing MDA content. Conclusions: diglyceride isolated from D. extraction, strong regulating metabolism. These findings could promote efficient utilization support development functional food applications.

Language: Английский

Citations

1
Exploring the potential mechanisms of polysaccharides against gastric ulcer: Network pharmacology analysis and molecular docking validation DOI Creative Commons

Jianhua Huang,

Qi Zou, Ming Hao

et al.

Food Safety and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Gastric ulcer is a common peptic that affects human health and life quality seriously. As anti‐gastric drugs usually cause side‐effects, polysaccharides may be the potential alternatives because of better effectiveness less toxicity. Although activities have been widely reported, mechanisms not yet well‐disclosed. In this study, network pharmacology analysis was performed to explore against gastric ulcer, results were validated by molecular docking. Results indicated β‐glucan, arabinogalactan, xylan, arabinan key structures, ABL1, AKT1, androgen receptor, epidermal growth factor v‐Ha‐ras Harvey rat sarcoma viral oncogene homolog, HSP90AA1, mitogen‐activated protein kinase 8 (MAPK8), MAPK14, NOS2, PIK3R1, RAC1, ras homolog gene family member A, proto‐oncogene tyrosine‐protein Src core targets for in treating ulcer. Polysaccharides influences on 1958 GO items 199 KEGG pathways, their are related MAPK, Ras, PI3K‐Akt, vascular endothelial factor, prolactin, FoxO Rap1 signaling etc. Molecular docking validation showed credible, interactions between polysaccharide structures observed. This study contributes understanding provides references future activity screening mechanism research

Language: Английский

Citations

0
Insights Into Metabolic Signatures and Regulatory Effect of Dendrobium officinale Polysaccharides in Gut Microbiota: A Comparative Study of Healthy and Diabetic Status DOI Creative Commons

Qianbo Song,

Junju Zou,

Sau Wan Cheng

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 6, 2024

ABSTRACT Dendrobium officinale is a kind of popular functional food to be consumed by both healthy and diabetic people. As its major constituent, D. polysaccharide (DOP) mainly utilized gut microbiota. Despite distinctive microbiota composition between individuals, no study compared the interplay DOP under status. The current aims investigate compare metabolic signatures regulatory potential on Our serial in vitro fermentation investigations found that mannose was more status with higher production propanoic acid lower butyric those Moreover, metabolomic analyses revealed different impacts intestinal microbial metabolites upregulating taurine downregulating 2‐hydroxybutyric only occurring Biodiversity demonstrated treatment could significantly improve diversity while there significant effect Further indicated promote probiotics ( Dubosiella , Bifidobacterium Akkermansia ) inhibit pathogens Escherichia‐Shigella In summary, our insights into effects provided scientific evidence for broad use as food.

Language: Английский

Citations

0