Alleviation Effect of the Secondary Metabolite of Anthocyanin (Protocatechuic Acid) on Heterocyclic Amine (IQ)-Induced Liver Injury and Its Underlying Mechanism

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Increased consumption of thermally processed meats caused a high risk accumulation heterocyclic amines (HCAs), which would lead to livery injuries and carcinogenic diseases in daily life. Our previous study found that cyanidin-3-glucoside expressed protective effect on 2-amino-3-methylimidazo [4,5-f] quinoline (IQ)-induced liver injury, but its intrinsic mechanism vivo was unclear. Thus, this aimed at investigating the alleviation secondary metabolite anthocyanin (protocatechuic acid) IQ-induced dysfunction underlying mechanism. The results demonstrated 4 weeks IQ (30 mg/kg) administration C57BL/6 mice induced significant oxidative stress were suppressed by PCA (10 20 supplement. Meanwhile, IQ-mediated inflammation mitigated supplementation via suppressing NF-κB/MAPK pathways signaling. Moreover, supplement significantly reversed intestinal damage tight junction dysfunction. Concurrently, 16s rRNA sequencing data indicated IQ-disturbed SCFAs content gut microbiota. Analysis correlation between microbiota, with manufacturers hepatic dysfunction, underscored significance gut-liver axis PCA-relieved injury stimulated IQ. Taken together, reduced modifying NF-κB/MAPK-NLRP3 inflammatory cascade, controlled barrier failure mediated In summary, our offer new perspectives microbiome-targeted therapeutic strategies for associated

Language: Английский

Exploring the Immunomodulatory Mechanisms of Osmunda japonica Thunb Polysaccharides: Activation of MAPK and NF-κB Signaling Pathways

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105695 - 105695

Published: Dec. 1, 2024

Language: Английский